Results 21 to 30 of about 12,669 (162)
Cells, 2022 The pregnane X receptor (PXR, NR1I2) is a xenobiotic-activated transcription factor with high levels of expression in the liver. It not only plays a key role in drug metabolism and elimination, but also promotes tumor growth, drug resistance, and ...
Rajamanikkam Kamaraj +3 more
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The Nuclear Receptor PXR in Chronic Liver Disease [PDF]
Cells, 2021 Pregnane X receptor (PXR), a nuclear receptor known for modulating the transcription of drug metabolizing enzymes and transporters (DMETs), such as cytochrome P450 3A4 and P-glycoprotein, is functionally involved in chronic liver diseases of different etiologies.
Sayaf K. +4 more
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The Role of PXR Genotype and Transporter Expression in the Placental Transport of Lopinavir in Mice
Pharmaceutics, 2017 Lopinavir (LPV), an antiretroviral protease inhibitor frequently prescribed in HIV-positive pregnancies, is a substrate of Abcb1 and Abcc2. As differences in placental expression of these transporters were seen in Pregnane X Receptor (PXR) −/− mice, we ...
Sarabjit S. Gahir +1 more
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PXR: a center of transcriptional regulation in cancer
Acta Pharmaceutica Sinica B, 2020 Pregnane X receptor (PXR, NR1I2) is a prototypical member of the nuclear receptor superfamily. PXR can be activated by both endobiotics and xenobiotics.
Yaqi Xing, Jiong Yan, Yongdong Niu
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Diagnostics, 2021 Pregnane X Receptor (PXR) is involved in human cancer, either by directly affecting carcinogenesis or by inducing drug-drug interactions and chemotherapy resistance.
Stamatios Theocharis +11 more
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Pregnane X Receptor (PXR) Polymorphisms and Cancer Treatment [PDF]
Biomolecules, 2021 Pregnane X Receptor (PXR) belongs to the nuclear receptors’ superfamily and mainly functions as a xenobiotic sensor activated by a variety of ligands. PXR is widely expressed in normal and malignant tissues. Drug metabolizing enzymes and transporters are also under PXR’s regulation. Antineoplastic agents are of particular interest since cancer patients
Aikaterini Skandalaki +2 more
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Small-molecule modulators of PXR and CAR [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2016 Two nuclear receptors, the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR), participate in the xenobiotic detoxification system by regulating the expression of drug-metabolizing enzymes and transporters in order to degrade and excrete foreign chemicals or endogenous metabolites.
Sergio C, Chai +3 more
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PXR and 4β-Hydroxycholesterol Axis and the Components of Metabolic Syndrome
Cells, 2020 Pregnane X receptor (PXR) activation has been found to regulate glucose and lipid metabolism and affect obesity in response to high-fat diets. PXR also modulates vascular tone.
Janne Hukkanen, Jukka Hakkola
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Novel complex of HAT protein TIP60 and nuclear receptor PXR promotes cell migration and adhesion
Scientific Reports, 2017 PXR is a member of nuclear receptor superfamily and a well-characterized mediator of xenobiotic metabolism. The classical mode of PXR activation involves its binding to appropriate ligand and subsequent heterodimerization with its partner RXR.
Karishma Bakshi +5 more
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Journal of Lipid Research, 2009 The nuclear hormone receptor pregnane X receptor (PXR; also called SXR) functions as a xenobiotic sensor to coordinately regulate xenobiotic metabolism via transcriptional regulation of xenobiotic-detoxifying enzymes and transporters.
Changcheng Zhou +3 more
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