Results 51 to 60 of about 12,669 (162)

Light‐Activated Micromotors in Air Propelled by Thermal Convection

Advanced Materials, Volume 38, Issue 1, 2 January 2026.
Near‐infrared‐driven micromotors in air can overcome gravity and generate convective motion by a light‐induced thermal mechanism driven by a temperature gradient in the air caused by the interaction of the gold nanoparticles present on the surface of ZnO and NIR irradiation.
Pedro Mena‐Giraldo, Gabrielle A. Mandl, Victor Quezada‐Novoa, Camilo Garcia‐Henao, Nicolas Bondon, Melanie Jane Hazlett, John A. Capobianco   +6 more
wiley   +1 more source

Elevated circulating pregnane X receptor as a novel diagnostic biomarker in hepatocellular carcinoma [PDF]

Exploration of Digestive Diseases
Aim: Hepatocellular carcinoma (HCC) poses a significant global health threat. The pregnane X receptor (PXR) is a central regulator of xenobiotic metabolism and plays a key role in mediating cellular resistance to anti-tumor drugs in HCC.
Balasubramaniyan Vairappan, Tanya Mishra, Biju Pottakkat   +2 more
doaj   +1 more source

PACS‐2 Mitigates NPSC Apoptosis and Intervertebral Disc Degeneration by Preserving MAM Integrity via the SP1/LRRK2/Mfn2 Axis

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study investigates the role of PACS‐2 in IDD, demonstrating that it suppresses the nuclear translocation of SP1, thereby downregulating its downstream target LRRK2. This reduces LRRK2‐mediated ubiquitination and degradation of Mfn2 through the JNK pathway, preserving MAM integrity and promoting NPSC survival.
Liang Kang, Jiaqi Wang, Chenhao Zhao, Qiuwei Li, Zhigang Zhang, Huaqing Zhang, Chongyu Jia, Luping Zhou, Yanxin Wang, Yu Chen, Kaixuan Li, Xu Yan, Jie Fang, Haibao Wang, Dandan Wang, Pingping Su, Jingyu Zhang, Zhiwei Chen, Renjie Zhang, Cailiang Shen   +19 more
wiley   +1 more source

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source

Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinoma

BMC Gastroenterology, 2011
Background The continuous exposure of esophageal epithelium to refluxate may induce ectopic expression of bile-responsive genes and contribute to the development of Barrett's esophagus (BE) and esophageal adenocarcinoma.
Kusters Johannes G, Siersema Peter D, van Dekken Herman, Pot Raymond GJ, Moons Leon MG, Capello Astrid, Menke Vivianda, van de Winkel Anouk, van der Laan Luc JW, Kuipers Ernst J   +9 more
doaj   +1 more source

Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation. [PDF]

J Med Chem
The pregnane X receptor (PXR) is an important regulator of hepatic metabolism, yet mechanistic insights into the effects of pharmacological inhibition using PXR inverse agonists or antagonists on critical genes involved in both xenobiotic and endobiotic metabolism remain limited.
Kamaraj R, Mejdrová I, Krutakova M, Smutny T, Škach K, Dohnalova K, Smutna L, Nellore DSS, Dusek J, Chalupsky K, Hricová J, Kronenberger T, Stahl A, Templin M, Braeuning A, Nencka R, Pavek P.   +16 more
europepmc   +3 more sources

Bile Acids as Key Mediators of the Gut Microbiota–Immune Axis: Potential Biomarker and Therapeutic Perspectives

BioFactors, Volume 52, Issue 1, January/February 2026.
Primary bile acids synthesized in the liver are transformed by gut microbes into secondary bile acids that engage receptors such as FXR and TGR5, thereby modulating immune function and metabolic homeostasis. Dysregulation of these signaling pathways contributes to MASH, NAFLD, IBD, and neurodegenerative disorders, underscoring their relevance as ...
Simone Baldi, Margherita Turrini, Francesco Cei, Marta Menicatti, Gianluca Bartolucci, Amedeo Amedei   +5 more
wiley   +1 more source

PXR antagonists and implication in drug metabolism

Drug Metabolism Reviews, 2013
Adopted orphan nuclear receptor (NR), pregnane X receptor (PXR), plays a central role in the regulation of xeno- and endobiotic metabolism. Since the discovery of the functional role of PXR in 1998, there is evolving evidence for the role of PXR agonists in abrogating metabolic pathophysiology (e.g., cholestasis, hypercholesterolemia, and inflammation).
Sridhar, Mani, Wei, Dou, Matthew R, Redinbo   +2 more
openaire   +3 more sources

Pregnenolone-16α-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms [PDF]

Biochemical Journal, 2005
The effect of liver growth stimulation [using the rodent PXR (pregnane X receptor) activator PCN (pregnenolone-16α-carbonitrile)] in rats chronically treated with carbon tetrachloride to cause repeated hepatocyte necrosis and liver fibrogenesis was examined. PCN did not inhibit the hepatotoxicity of carbon tetrachloride.
Carylyn J, Marek, Steven J, Tucker, Dimitrios K, Konstantinou, Lucy J, Elrick, Dee, Haefner, Charalambos, Sigalas, Graeme I, Murray, Bryan, Goodwin, Matthew C, Wright   +8 more
openaire   +2 more sources

SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells

Journal of Pharmacological Sciences, 2016
The pregnane X receptor (PXR) has been well-established as a critical mediator in regulating important drug metabolizing enzymes and transporter proteins, including cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp).
Huasen Tan, Chenshu Xu, Hang Zeng, Ying Wang, Yingmei Li, Xiaomei Fan, Pan Chen, Yiming Jiang, Xiao Chen, Min Huang, Huichang Bi   +10 more
doaj   +1 more source