Results 81 to 90 of about 12,669 (162)

Nuclear receptors CAR and PXR as cardiometabolic regulators

Pharmacological Research
The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) were initially described as xenobiotic sensors, but an increasing number of studies have linked their activity to other important physiological processes including glucose and lipid
Janne Hukkanen, Jenni Küblbeck, Jukka Hakkola, Jaana Rysä   +3 more
doaj   +1 more source

Pregnane × Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation

Molecular Cancer, 2010
Background Clinical efficacy of chemotherapy in colorectal cancer is subjected to broad inter-individual variations leading to the inability to predict outcome and toxicity.
Lumbroso Serge, Hollande Frédéric, Joubert Dominique, Bonnans Caroline, Poujol Sylvain, Lallemant Benjamin, Kantar Jovana, Breuker Cyril, Leguelinel Géraldine, Pascussi Jean-Marc, Raynal Caroline, Brouillet Jean-Paul, Evrard Alexandre   +12 more
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ChIPing the cistrome of PXR in mouse liver

Nucleic Acids Research, 2010
The pregnane X receptor (PXR) is a key regulator of xenobiotic metabolism and disposition in liver. However, little is known about the PXR DNA-binding signatures in vivo, or how PXR regulates novel direct targets on a genome-wide scale. Therefore, we generated a roadmap of hepatic PXR bindings in the entire mouse genome [chromatin immunoprecipitation ...
Cui, Julia Yue, Gunewardena, Sumedha S., Rockwell, Cheryl E., Klaassen, Curtis D.   +3 more
openaire   +2 more sources

The intestinal functions of PXR and CAR

Pharmacological Research
Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are so-called xenobiotic nuclear receptors that play pivotal roles in xenobiotic metabolism and detoxification. Both receptors, highly expressed in the liver and intestine, also have endobiotic functions by regulating the homeostasis of endogenous chemicals.
Ye Feng, Jong-Won Kim, Wen Xie
openaire   +3 more sources

PXR as a mediator of herb–drug interaction

Journal of Food and Drug Analysis, 2018
Medicinal herbs have been a part of human medicine for thousands of years. The herb-drug interaction is an extension of drug-drug interaction, in which the consumptions of herbs cause alterations in the metabolism of drugs the patients happen to take at the same time.
Hogle, Brett C., Guan, Xiudong, Folan, M. Maggie, Xie, Wen   +3 more
openaire   +2 more sources

Identification of human pregnane X receptor antagonists utilizing a high-throughput screening platform

Frontiers in Pharmacology
Pregnane X receptor (PXR) is a xenobiotic-sensing nuclear receptor with a well-established role in regulating drug metabolism and clearance. Recent studies have shown that PXR is involved in cell proliferation, apoptosis, immune response, and energy ...
Caitlin Lynch, Ryan Margolis, Jacob Niebler, Jameson Travers, Srilatha Sakamuru, Tongan Zhao, Carleen Klumpp-Thomas, Ruili Huang, Menghang Xia   +8 more
doaj   +1 more source

Renoprotection through PXR–AKR1B7 [PDF]

Nature Reviews Nephrology, 2020
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Pregnane X receptor reduces particulate matter-induced type 17 inflammation in atopic dermatitis

Frontiers in Immunology
BackgroundEpidemiological evidence suggests that particulate matter (PM) exposure can trigger or worsen atopic dermatitis (AD); however, the underlying mechanisms remain unclear. Recently, pregnane X receptor (PXR), a xenobiotic receptor, was reported to
Ji Su Lee, Ji Su Lee, Youngae Lee, Youngae Lee, Youngae Lee, Sunhyae Jang, Sunhyae Jang, Sunhyae Jang, Jang-Hee Oh, Jang-Hee Oh, Jang-Hee Oh, Dong Hun Lee, Dong Hun Lee, Dong Hun Lee, Dong Hun Lee, Soyun Cho, Soyun Cho, Soyun Cho   +17 more
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B3galt5 functions as a PXR target gene and regulates obesity and insulin resistance by maintaining intestinal integrity

Nature Communications
Pregnane X receptor (PXR) has been reported to regulate glycolipid metabolism. The dysfunction of intestinal barrier contributes to metabolic disorders. However, the role of intestinal PXR in metabolic diseases remains largely unknown. Here, we show that
Jinhang Zhang, Ya Huang, Hong Li, Pengfei Xu, Qinhui Liu, Yang Sun, Zijing Zhang, Tong Wu, Qin Tang, Qingyi Jia, Yan Xia, Ying Xu, Xiandan Jing, Jiahui Li, Li Mo, Wen Xie, Aijuan Qu, Jinhan He, Yanping Li   +18 more
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Πολυμορφισμοί PXR και καρκίνος

, 2021
Ο υποδοχέας Χ πρεγνανίου (Pregnane X Receptor/PXR) ανήκει στην υπεροικογένεια των πυρηνικών υποδοχέων και κυρίως λειτουργεί ως αισθητήρας ξενοβιοτικών ουσιών και ενεργοποιείται από μια πληθώρα μορίων. Ο PXR εκφράζεται ευρέως σε φυσιολογικούς και κακοήθεις ιστούς. Τα ένζυμα μεταβολισμού φαρμάκων και πρωτεΐνες-μεταφορείς υπόκεινται επίσης υπό την ρύθμιση
openaire   +1 more source