Results 41 to 50 of about 810 (104)

Rational design of a covalent ACE2 decoy receptor that broadly neutralizes SARS‐CoV‐2 variants

Protein Science, Volume 34, Issue 10, October 2025.
Abstract The ongoing evolution of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and the emergence of variants that evade existing vaccines and antibody therapies necessitate novel, potent, and broad‐spectrum antiviral strategies. Enhancing therapeutic proteins with additional covalent binding capabilities, such as minibinders and ...
Nobumasa Hino, Risa Takada, Kyosuke Suzuki, Nagisa Tokunoh, Tatsuya Karaki, Kazumasa Ohtake, Haruna Ogami, Takafumi Nishiura, Kenji Ishimoto, Tomohito Tsukamoto, Yukio Ago, Yoshiaki Okada, Toru Okamoto, Chikako Ono, Yoshiharu Matsuura, Satoshi Obika, Kensaku Sakamoto, Yasuo Yoshioka, Shinsaku Nakagawa   +18 more
wiley   +1 more source

Spatiotemporal Control Over Protein Release from Artificial Cells via a Light‐Activatable Protease

Advanced Biology, Volume 9, Issue 5, May 2025.
Stimulus‐responsive protein release is essential for intercellular communication. Mimicking this functionality in artificial cells is promising to study the working principles of cellular signaling. Herein, an engineered light‐activatable protease is implemented in a coacervate‐based artificial cell platform to establish user‐defined spatiotemporal ...
Arjan Hazegh Nikroo, Wiggert J. Altenburg, Thijs W. van Veldhuisen, Luc Brunsveld, Jan C. M. van Hest   +4 more
wiley   +1 more source

Metal‐Mediated Protein Engineering within Live Cells

Chemistry – An Asian Journal, Volume 20, Issue 6, March 17, 2025.
This review discusses how metal ions can mediate protein modification within live cells. With its easy handling, rapid solubility, and ease of internalization within the cells, metal ions can be an excellent stimulus for many organic reactions needed within an intracellular medium, which can modify proteins and lead to applications in chemistry ...
Pritam Ghosh
wiley   +1 more source

Light‐Activatable Ubiquitin for Studying Linkage‐Specific Ubiquitin Chain Formation Kinetics

Advanced Science, Volume 12, Issue 6, February 10, 2025.
Ubiquitin dynamically forms differently linked polyubiquitin chains. To study rapid cellular kinetics of global linkage‐specific ubiquitination, light‐activatable polyubiquitin chain formation is reported via incorporation of a photocaged lysine. Minute‐scale ubiquitination kinetics for different linkages are observed, and the impact of ubiquitination ...
Sudakshina Banerjee, Zeyneb Vildan Cakil, Kai Gallant, Johannes van den Boom, Shubhendu Palei, Hemmo Meyer, Malte Gersch, Daniel Summerer   +7 more
wiley   +1 more source

Genetic Incorporation of Diverse Noncanonical Amino Acids for Histidine Substitution. [PDF]

J Am Chem Soc
Natter Perdiguero A, Fischer S, Lischke AR, Manser BP, Deliz Liang A.   +4 more
europepmc   +2 more sources

Photocaged FLP recombinase for precise spatio-temporal control of gene expression. [PDF]

Nucleic Acids Res
Rodriguez JJV, Baxter K, Ma Y, Greiss S.
europepmc   +2 more sources

Genomically integrated orthogonal translation system in Escherichia coli enables production of functional modified [NiFe]-hydrogenases. [PDF]

Microb Cell Fact
Fan Q, Stevanie S, Frielingsdorf S, Neubauer P, Lenz O, Gimpel M.   +5 more
europepmc   +1 more source

Expanding the Genetic Code with Lysine Aminoacylation. [PDF]

J Am Chem Soc
Li X, Gan Q, Fan C.
europepmc   +1 more source

A Genetically Encoded Electrophilic Lysine Derivative Enables Sortase-Mediated Assembly of SUMO Activity-Based Probes. [PDF]

J Am Chem Soc
Wanka V, Kvasha D, Cigler M, Heymes-Krauskopf K, Ruckgaber P, Heider A, Fottner M, Groll M, Lang K.   +8 more
europepmc   +1 more source

Advancing Genetically Encoded Lysine (GEK) Chemistry: From Precision Modulation to Therapeutic Innovation. [PDF]

Acc Chem Res
Jin G, Shi Y, Sharma S, Liu WR.
europepmc   +1 more source