Results 51 to 60 of about 4,864,845 (302)

Pyramidal cells accumulate chloride at seizure onset [PDF]

Neurobiology of Disease, 2012
Seizures are thought to originate from a failure of inhibition to quell hyperactive neural circuits, but the nature of this failure remains unknown. Here we combine high-speed two-photon imaging with electrophysiological recordings to directly evaluate the interaction between populations of interneurons and principal cells during the onset of seizure ...
Kyle P. Lillis, Mark A. Kramer, Jerome Mertz, Kevin J. Staley, John A. White   +4 more
openaire   +3 more sources

Association Between Neurofilament Light Chain and Real‐World Ambulatory Function in Progressive MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurofilament light chain (NfL) is a biomarker of neuroaxonal injury in multiple sclerosis (MS), yet associations with functional outcomes remain unclear. Longitudinal associations between serum NfL (sNfL) and daily step count (STEPS) from wearable devices were assessed in a large international progressive MS cohort.
Gabby B. Joseph, Megan McCune, Riley Bove, Ahmed Abdelhak, Bruce A. C. Cree, Valerie J. Block   +5 more
wiley   +1 more source

The large numbers of minicolumns in the primary visual cortex of humans, chimpanzees and gorillas are related to high visual acuity

Frontiers in Neuroanatomy, 2022
Minicolumns are thought to be a fundamental neural unit in the neocortex and their replication may have formed the basis of the rapid cortical expansion that occurred during primate evolution.
Mark N. Wallace, Mark N. Wallace, Oliver Zobay, Oliver Zobay, Eden Hardman, Zoe Thompson, Phillipa Dobbs, Lisa Chakrabarti, Alan R. Palmer, Alan R. Palmer   +9 more
doaj   +1 more source

Complementing Engel Classification: Postoperative Scalp EEG as an Objective Indicator in SEEG‐Guided Radiofrequency Thermocoagulation—A Seizure‐Onset Pattern‐Based Stratified Analysis—

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) is a minimally invasive therapy for drug‐resistant focal epilepsy. However, the relationship between specific seizure‐onset patterns (SOPs), particularly low‐voltage fast activity (LVFA), and postoperative scalp EEG normalization remains inadequately ...
Yi‐qing Yang, Rui Zhang, Haiyan Ma, Lu Yang, Xuefeng Qu, Qiqi Chen, Yan Zhang   +6 more
wiley   +1 more source

Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior

eLife, 2020
In vitro work revealed that excitatory synaptic inputs to hippocampal inhibitory interneurons could undergo Hebbian, associative, or non-associative plasticity.
Igor Gridchyn, Philipp Schoenenberger, Joseph O'Neill, Jozsef Csicsvari   +3 more
doaj   +1 more source

Changes in Cyclin D1, cdk4, and Their Associated Molecules in Ischemic Pyramidal Neurons in Gerbil Hippocampus after Transient Ischemia and Neuroprotective Effects of Ischemic Preconditioning by Keeping the Molecules in the Ischemic Neurons

Biology, 2021
Inadequate activation of cell cycle proteins including cyclin D1 and cdk4 is involved in neuronal cell death induced by diverse pathological stresses, including transient global brain ischemia.
Tae-Kyeong Lee, Dae Won Kim, Jae-Chul Lee, Cheol Woo Park, Hyejin Sim, Ji Hyeon Ahn, Joon Ha Park, Myoung Cheol Shin, Jun Hwi Cho, Choong-Hyun Lee, Moo-Ho Won, Soo Young Choi   +11 more
doaj   +1 more source

Juvenile Huntington Disease With Cerebellar‐Predominant Atrophy Identified by Genome Sequencing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Juvenile Huntington disease accounts for a small fraction of Huntington disease cases and is driven by the largest trinucleotide repeat expansions. We describe a 6‐year‐old boy with progressive global regression, generalized dystonia, and epilepsy, in whom serial imaging showed striking cerebellar‐predominant atrophy with an initially normal ...
Enrique Gonzalez Saez‐Diez, Amy Tam, Siofra Carty, Monica Ferrer Socorro, Kathryn Yang, Darius Ebrahimi‐Fakhari   +5 more
wiley   +1 more source

EPSPs in rat neocortical neurons in vitro. I. Electrophysiological evidence for two distinct EPSPs [PDF]

, 1989
1. To investigate excitatory postsynaptic potentials (EPSPs), intracellular recordings were performed in layer II/III neurons of the rat medial frontal cortex.
J. J. Hablitz, Sutor, Bernd, Hablitz, John H., B. Sutor   +3 more
core   +2 more sources

Physiological sharp wave-ripples and interictal events in vitro: What’s the difference? [PDF]

, 2014
Sharp wave-ripples and interictal events are physiological and pathological forms of transient high activity in the hippocampus with similar features.
Káli, Szabolcs, Karlócai, R. Mária, Gulyás, Attila, Kohus, Zsolt, Máté, Zoltán, Szabó, Gábor, Ulbert, István, Freund, Tamás   +7 more
core   +1 more source

Interaction of Norepinephrine and Glucocorticoids Modulate Inhibition of Principle Cells of Layer II Medial Entorhinal Cortex in Male Mice

Frontiers in Synaptic Neuroscience, 2018
Spatial memory processing requires functional interaction between the hippocampus and the medial entorhinal cortex (MEC). The grid cells of the MEC are most abundant in layer II and rely on a complex network of local inhibitory interneurons to generate ...
Jeremiah P. Hartner, Laura A. Schrader, Laura A. Schrader   +2 more
doaj   +1 more source