Results 91 to 100 of about 26,737 (201)

Synthesis of pyrazinamide analogs of aspirin

, 2012
Pyrazinamide derivatives of aspirin (6a) and (6b) were synthesized. The synthesis involved teh Friedel Crafts acylation of methyl salicylate using the appropriate alkanoyl chloride and ZnCl2 as catalyst followed by hydrolysis to produce the precursor ...
Alea, Glenn V., Lagua, Faith Marie G., Ajero, Michael Dominic M.   +2 more
core  

Lung Tissue Concentrations of Pyrazinamide among Patients with Drug-Resistant Pulmonary Tuberculosis

, 2017
Improved knowledge regarding the tissue penetration of antituberculosis drugs may help optimize drug management. Patients with drug-resistant pulmonary tuberculosis undergoing adjunctive surgery were enrolled.
Hartmut Derendorf, Irina Sabulua, Russell R. Kempker, M. Tobias Heinrichs, Charles A. Peloquin, Sergo Vashakidze, Shota Gogishvili, Nestani Tukvadze, Zaza Avaliani, Timothy D. Read, Jeannette Guarner, Nino Bablishvili, Brent Little, Ketino Nikolaishvili, Adam Bernheim, Henry M. Blumberg   +15 more
core   +1 more source

Population pharmacokinetics and pharmacokinetic-pharmacodyamic modeling of antitubercular drugs [PDF]

, 2013
Includes abstract.Includes bibliographical references.The pharmacokinetics of rifampicin, isoniazid, pyrazinamide and ethambutol in 78 patients with tuberculosis were described using non-linear mixed effects modeling.
Chigutsa, Emmanuel
core   +1 more source

Phenotypic and genotypic characterization of Mycobacterium tuberculosis pyrazinamide resistance—India, 2018–2020

Frontiers in Microbiology
Pyrazinamide (PZA) is a key first-line antituberculosis drug that plays an important role in eradicating persister Mycobacterium tuberculosis (TB) bacilli and shortening the duration of tuberculosis treatment.
Sembulingam Tamilzhalagan, Evanslin Santus Justin, Ashok Selvaraj, Karthick Venkateswaran, Arun Kumar Sivakumar, Suganthi Chittibabu, Heather P. McLaughlin, Patrick K. Moonan, Jonathan P. Smith, Sakthi Suba, Mukesh Kumar Sathya Narayanan, Christine S. Ho, Nishant Kumar, Srikanth P. Tripathy, Srikanth P. Tripathy, Siva K. Shanmugam, Patricia J. Hall-Eidson, Uma Devi Ranganathan   +17 more
doaj   +1 more source

Pyrazinamide induced photodermatitis: a case report

, 2019
Photosensitivity reactions due to pyrazinamide are rare. In this report, a case of pyrazinamide induced photodermatitis has been reported in a patient who is one anti-tuberculosis treatment.
Robin George, E. Sunil Kumar, T. Saranya, A. Heena Kauser   +3 more
core  

Clinical Significance of Preoperative Pyrazinamide-Containing Therapy in Tuberculous Constrictive Pericarditis

Infection and Drug Resistance
Likui Fang, Wenfeng Yu, Guocan Yu, Gang Chen, Bo Ye Department of Thoracic Surgery, Hangzhou Red Cross Hospital, Hangzhou, 310003, People’s Republic of ChinaCorrespondence: Likui Fang, Department of Thoracic Surgery, Hangzhou Red Cross Hospital, Hangzhou,
Fang L, Yu W, Yu G, Chen G, Ye B
doaj  

Dose-Dependent Activity of Pyrazinamide in Animal Models of Intracellular and Extracellular Tuberculosis Infections

, 2011
Recent in vitro pharmacokinetic data suggest that the currently recommended dose of pyrazinamide may be suboptimal for killing intracellular bacilli in humans.
Eric L. Nuermberger, Petros C. Karakousis, Jacques H. Grosset, Zahoor Ahmad, Mostafa M. Fraig, Gregory P. Bisson   +5 more
core   +1 more source

Toward precision detection of pyrazinamide resistance: critical concentration assessment and rapid molecular method validation

Frontiers in Microbiology
This study evaluated broth microdilution (BMD) and fluorescence PCR melting curve analysis (MeltPro MTB/PZA, targeting pncA mutations) for detecting pyrazinamide (PZA) resistance-associated mutations in rifampicin-resistant tuberculosis (RR-TB).
Yanfeng Zhao, Lili Tian, Nenhan Wang, Hao Chen, Shuangshuang Chen, Lan Yu, Mengdi Pang, Beichuan Ding, Jie Li, Chuanyou Li, Xiaowei Dai, Xiaowei Dai   +11 more
doaj   +1 more source

The Identification of Novel Mutations in ATP-Dependent Protease ClpC1 Assists in the Molecular Diagnosis of Obscured Pyrazinamide-Resistant Tuberculosis Clinical Isolates

Microorganisms
Pyrazinamide (PZA) is a key component of tuberculosis treatment, with drug resistance (PZAR) primarily related to pncA mutations. However, discordance between phenotypic resistance and conventional pncA-based molecular diagnostics challenges diagnostic ...
H. M. Adnan Hameed, Cuiting Fang, Zhiyong Liu, Yamin Gao, Shuai Wang, Xinwen Chen, Nanshan Zhong, Htin Lin Aung, Jinxing Hu, Tianyu Zhang   +9 more
doaj   +1 more source

Resistance To First-Line Antituberculosis Drugs And Prevalence Of pncA Mutations In Clinical Isolates Of Mycobacterium tuberculosis From Zunyi, Guizhou Province Of China

Infection and Drug Resistance, 2019
Zhimin Cao,1 Yuanbo Lan,1 Ling Chen,1 Min Xiang,1 Zhiyuan Peng,1 Jianyong Zhang,1 Hong Zhang1,2 1Tuberculosis Division, Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, People ...
Cao Z, Lan Y, Chen L, Xiang M, Peng Z, Zhang J, Zhang H   +6 more
doaj