Results 81 to 90 of about 25,215 (206)

Les interactions entre la pyrazinamide et des dérivés d'urée et leur rôle dans la stabilisation de la forme gamma de la pyrazinamide

, 2021
A previous study has demonstrated that the γ polymorph of pyrazinamide, which is metastable at room temperature, has a significantly increased persistence when obtained by spray drying in the presence of 1,3-dimethylurea.
Li, Kangli
core   +1 more source

The molecular basis of resistance to isoniazid, rifampin, and pyrazinamide in Mycobacterium tuberculosis

Respiratory Research, 2001
Multidrug-resistant (MDR) strains of Mycobacterium tuberculosis have emerged worldwide. In many countries and regions, these resistant strains constitute a serious threat to the efficacy of tuberculosis control programs.
Parsons Linda M, Somoskovi Akos, Salfinger Max   +2 more
doaj   +1 more source

Pyrazinamide deamidase activity in tuberculous disease

, 1981
To investigate whether pyrazinamide deamidase activity is suppressed in tuberculosls, serial serum concentrations of pyrazinamide, following 40 mg of pyrazinamide per kg, were determined in 10 patients with-sputum positive pulmonary tuberculosis and in
Gurumurthy, Prema, Krishnamurthy, P V, Raghupati Sarma, G   +2 more
core  

RP-DAD-HPLC Method for Quantitative Analysis of Clofazimine and Pyrazinamide for Inclusion in Fixed-Dose Combination Topical Drug Delivery System

Methods and Protocols
Reversed-phase high-performance liquid chromatography (RP-HPLC) remains one of the most widely applied analytical techniques in the development and quality control testing of finished pharmaceutical products.
Marius Brits, Francelle Bouwer, Joe M. Viljoen   +2 more
doaj   +1 more source

Lung Tissue Concentrations of Pyrazinamide among Patients with Drug-Resistant Pulmonary Tuberculosis

, 2017
Improved knowledge regarding the tissue penetration of antituberculosis drugs may help optimize drug management. Patients with drug-resistant pulmonary tuberculosis undergoing adjunctive surgery were enrolled.
Hartmut Derendorf, Irina Sabulua, Russell R. Kempker, M. Tobias Heinrichs, Charles A. Peloquin, Sergo Vashakidze, Shota Gogishvili, Nestani Tukvadze, Zaza Avaliani, Timothy D. Read, Jeannette Guarner, Nino Bablishvili, Brent Little, Ketino Nikolaishvili, Adam Bernheim, Henry M. Blumberg   +15 more
core   +1 more source

Pyrazinamide-induced phototoxicity: A case report and review of literature

Indian Journal of Dermatology, 2010
A 40-year-old male presented with a fresh case of pulmonary tuberculosis and itchy oozing rashes distributed characteristically over the sun exposed areas of the skin. These rashes had developed since six days following 10 days of start of antitubercular
Katiyar Subodh, Bihari Shailesh, Prakash Shivesh   +2 more
doaj  

Substituted N-(Pyrazin-2-yl)benzenesulfonamides; Synthesis, Anti-Infective Evaluation, Cytotoxicity, and In Silico Studies

Molecules, 2019
We prepared a series of substituted N-(pyrazin-2-yl)benzenesulfonamides as an attempt to investigate the effect of different linkers connecting pyrazine to benzene cores on antimicrobial activity when compared to our previous compounds of amide or retro ...
Ghada Bouz, Martin Juhás, Lluis Pausas Otero, Cristina Paredes de la Red, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Vladimír Kubíček, Jiří Janoušek, Martin Doležal, Jan Zitko   +10 more
doaj   +1 more source

Synthesis of pyrazinamide analogs of aspirin

, 2012
Pyrazinamide derivatives of aspirin (6a) and (6b) were synthesized. The synthesis involved teh Friedel Crafts acylation of methyl salicylate using the appropriate alkanoyl chloride and ZnCl2 as catalyst followed by hydrolysis to produce the precursor ...
Alea, Glenn V., Lagua, Faith Marie G., Ajero, Michael Dominic M.   +2 more
core  

Pyrazinamide-Induced Exfoliative Dermatitis in a Patient on Hemodialysis: A Rare Complication [PDF]

, 2013
A 60-year-old male patient on maintenance hemodialysis was started on antituberculosis therapy with isoniazid, rifampin, ethambutol, and pyrazinamide for pulmonary tuberculosis.
Krishnaswamy Jaisuresh
core   +1 more source

Comparison of Pyrazinamide with Isoniazid for Their Effects on the Heme Biosynthetic Pathway in Mouse Liver

Metabolites
Background/Objectives: Isoniazid (INH) and pyrazinamide (PZA) are first-line drugs used to treat tuberculosis (TB), but their use is generally contraindicated in patients with porphyria, a group of metabolic disorders caused by defects in the heme ...
Fu-Ying Qin, Ruizhi Gu, Jiaojiao Zhang, Jaden Leigh Weiss, Jie Lu, Qing Ma, Xiaochao Ma   +6 more
doaj   +1 more source