Results 81 to 90 of about 26,737 (201)

Synthesis, Antimycobacterial Activity and In Vitro Cytotoxicity of 5-Chloro-N-phenylpyrazine-2-carboxamides

Molecules, 2013
5-Chloropyrazinamide (5-Cl-PZA) is an inhibitor of mycobacterial fatty acid synthase I with a broad spectrum of antimycobacterial activity in vitro. Some N-phenylpyrazine-2-carboxamides with different substituents on both the pyrazine and phenyl core ...
Jan Zitko, Barbora Servusová, Pavla Paterová, Jana Mandíková, Vladimír Kubíček, Radim Kučera, Veronika Hrabcová, Jiří Kuneš, Ondřej Soukup, Martin Doležal   +9 more
doaj   +1 more source

Prevalence and Clinical Implications of Pyrazinamide Resistance in Newly Diagnosed TB Patients in Uganda [PDF]

Christopher Ndawula, Nalumaga Pauline Petra, Fredrickson B Wasswa, Joel Bazira Department of Microbiology, Mbarara University of Science and Technology, Mbarara, 1410, UgandaCorrespondence: Joel Bazira, Email jbazira@must.ac.ugBackground: Globally, 10.8 ...
Bazira J, Petra NP, Ndawula C, Wasswa FB
core  

Role of rifampicin in arthralgia induced by pyrazinamide

, 1983
Arthralgia during daily treatment with chemotherapy regimens containing pyrazinamide was found to be considerably less in patients who received rifampicin concomitantly.
Gurumurthy, Prema, Acharyulu, G S, Krishnamurthy, P V, Kannapiran, M, Raghupati Sharma, G, Tripathy, S P   +5 more
core   +1 more source

Protective Effect of Bicyclol on Anti-Tuberculosis Drug Induced Liver Injury in Rats

Molecules, 2017
The present study was performed to investigate the effect of bicyclol, a synthetic anti-hepatitis drug with anti-oxidative and anti-inflammatory properties, on anti-tuberculosis (anti-TB) drug-induced liver injury and related mechanisms in rats. Bicyclol
Xin Liu, Manman Zhao, Jiaqi Mi, Hui Chen, Li Sheng, Yan Li   +5 more
doaj   +1 more source

Drug rash with eosinophilia and systemic symptoms syndrome due to anti-TB medication

Journal of Family Medicine and Primary Care, 2013
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a severe, idiosyncratic, multi-system reaction characterized by the clinical triad of fever, rash, and internal organ involvement.
Dharmesh H Kaswala
doaj   +1 more source

RP-DAD-HPLC Method for Quantitative Analysis of Clofazimine and Pyrazinamide for Inclusion in Fixed-Dose Combination Topical Drug Delivery System

Methods and Protocols
Reversed-phase high-performance liquid chromatography (RP-HPLC) remains one of the most widely applied analytical techniques in the development and quality control testing of finished pharmaceutical products.
Marius Brits, Francelle Bouwer, Joe M. Viljoen   +2 more
doaj   +1 more source

Pyrazinamide-induced phototoxicity: A case report and review of literature

Indian Journal of Dermatology, 2010
A 40-year-old male presented with a fresh case of pulmonary tuberculosis and itchy oozing rashes distributed characteristically over the sun exposed areas of the skin. These rashes had developed since six days following 10 days of start of antitubercular
Katiyar Subodh, Bihari Shailesh, Prakash Shivesh   +2 more
doaj  

Weekly pulmonary delivery of β-glucan-chitosan-poly(lactic co-glycolic) acid (β-C-P) nanoparticles with daily standard oral therapy achieves control of Mycobacterium tuberculosis in BALB/c mice

Antimicrobial Agents and Chemotherapy
Prolonged daily tuberculosis therapy contributes to toxicity, poor adherence, and drug resistance. We developed rifampin (RIF)-loaded β-glucan-chitosan-poly (lactic co-glycolic) acid nanoparticles (β-C-P nanoparticles) for weekly pulmonary delivery and ...
Hilliard L. Kutscher, Maria Tamblin, Patrick Kenney, Jessica L. Reynolds   +3 more
doaj   +1 more source

Plasma drug activity assay for treatment optimization in tuberculosis patients [PDF]

, 2011
Item does not contain fulltextLow antituberculosis (TB) drug levels are common, but their clinical significance remains unclear, and methods of measurement are resource intensive.
Scott K. Heysell, Mpagama, S., Kibiki, Gibson S, Houpt, Eric R, Mwaigwisya, S., Heysell, Scott K, Ndusilo, Norah, Pholwat, Suporn, Mwaigwisya, Solomon, Kibiki, G.S., Solomon Mwaigwisya, Suporn Pholwat, Jean Gratz, Mtabho, C., Aarnoutse, R.E., Stellah Mpagama, Heysell, S.K., Rob E. Aarnoutse, Charles Mtabho, Gratz, J., Mpagama, Stellah, Norah Ndusilo, Gratz, Jean, Houpt, E.R., Gibson S. Kibiki, Eric R. Houpt, Mtabho, Charles, Aarnoutse, Rob E, Ndusilo, N., Pholwat, S.   +29 more
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Les interactions entre la pyrazinamide et des dérivés d'urée et leur rôle dans la stabilisation de la forme gamma de la pyrazinamide

, 2021
A previous study has demonstrated that the γ polymorph of pyrazinamide, which is metastable at room temperature, has a significantly increased persistence when obtained by spray drying in the presence of 1,3-dimethylurea.
Li, Kangli
core   +1 more source