Results 41 to 50 of about 35,915 (205)

Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations. [PDF]

, 2019
Fluoroquinolones represent the pillar of multidrug-resistant tuberculosis (MDR-TB) treatment, with moxifloxacin, levofloxacin, or gatifloxacin being prescribed to MDR-TB patients.
Alvarez-Cabrera, Nadine, Blanc, Landry, Dartois, Véronique, Dias-Freedman, Isabela, Dietzold, Jillian, Ho Liang, Hsin-Pin, Kaya, Firat, Kirschner, Denise, Linderman, Jennifer, Mina, Marizel, O'Brien, Paul, Pienaar, Elsje, Prideaux, Brendan, Salgame, Padmini, Sarathy, Jansy, Savic, Radojka M, Zimmerman, Matthew   +16 more
core   +2 more sources

Clinical Pharmacology Quality Assurance Program for Global HIV and Co‐Infection Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
When the acquired immunodeficiency syndrome emerged in the 1980s, the United States National Institutes of Health established research networks to conduct clinical trials with the pharmaceutical industry to identify effective antiretroviral therapeutics.
Robin DiFrancesco, Troy D. Wood, Raymond Cha, Jill S. Hochreiter, Susan L. Rosenkranz, Mona Farhad, Kyle R. Whitson, Connor E. Gould, Lauren E. Hill, Linda L. Hale, Philip H. Lindhorst, Diala Ghazal, Charlene R. Taylor, Madiha Quraishi, Suzanne M. Siminski, Yoninah Cramer, Heather L. Sprenger, Gene D. Morse   +17 more
wiley   +1 more source

Drug rash with eosinophilia and systemic symptoms syndrome due to anti-TB medication

Journal of Family Medicine and Primary Care, 2013
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a severe, idiosyncratic, multi-system reaction characterized by the clinical triad of fever, rash, and internal organ involvement.
Dharmesh H Kaswala
doaj   +1 more source

Pharmacokinetic assessment of pyrazinamide and pyrazinoic acid in carbon tetrachloride-induced liver injury model in Wistar Rats

Journal of Pharmacy and Bioallied Sciences, 2023
Background: We investigated the pharmacokinetic behavior of pyrazinamide (PZA) and pyrazinoic acid (PA) in the presence of carbon-tetrachloride (CCl4) plus antitubercular treatment (ATT) drug-induced liver injury (DILI) in rats.
Swati Sharma, Vishal Sharma, Sunil Taneja, Alka Bhatia, Aishwarya Anand, Dibyajyoti Banerjee, Amol N Patil   +6 more
doaj   +1 more source

Drug Exposure and Susceptibility of Pyrazinamide Correlate with Treatment Response in Pyrazinamide-Susceptible Patients with Multidrug-Resistant Tuberculosis

Pharmaceutics
Exploring the influence of pyrazinamide exposure and susceptibility on treatment response is crucial for optimizing the management of multidrug-resistant tuberculosis (MDR-TB). This study aimed to investigate the association between pyrazinamide exposure,
Shulan Dong, Ge Shao, Lina Davies Forsman, Sainan Wang, Shanshan Wang, Jiayi Cao, Ziwei Bao, Judith Bruchfeld, Jan-Willem C. Alffenaar, Jia Liu, Yi Hu, Meiying Wu   +11 more
doaj   +1 more source

The bactericidal activity of moxifloxacin in patients with pulmonary tuberculosis [PDF]

, 2003
Patients in whom acid-fast bacilli smear-positive pulmonary tuberculosis was newly diagnosed were randomized to receive 400 mg moxifloxacin, 300 mg isonaizid, or 600 mg rifampin daily for 5 days. Sixteen-hour overnight sputa collections were made for the
Bongard, E, Gillespie, SH, Gosling, RD, Kanduma, EG, Morris, RW, Nyindo, M, Sam, NE, Uiso, LO   +7 more
core   +1 more source

Clinical management of drug resistant tuberculosis: A comprehensive review

Asian Journal of Medical Sciences, 2014
Despite the introduction 40 years ago of the inexpensive and effective four-drug (isoniazid, rifampicin, pyrazinamide and ethambutol) treatment regimen, tuberculosis (TB) continues to cause considerable morbidity and mortality worldwide.
Arun Kumar
doaj   +1 more source

Pengembangan Dan Validasi Metode Analisis Rifampicin Isoniazid-pirazinamid Dalam Fixed Dose Combination Dengan Metode Kromatografi Lapis Tipis-densitometri [PDF]

, 2012
Rifampicin, isoniazid (INH) and pyrazinamide are anti tuberculosis drugs (ATD) available in fixed dose combination (FDC) form. The FDC is more practical in USAge so can improve tuberculosis patient obedience in consuming the drug.
Fauziyah, L. (Laily), Prabowo, M. H. (Muhammad), Wibowo, A. (Ari)   +2 more
core   +1 more source

Epicutaneous and Drug Provocation Testing in Severe Cutaneous Adverse Reactions: A 20‐Year Single‐Centre Experience

Contact Dermatitis, EarlyView.
This study provides reassuring evidence in favour of early skin testing in patients with SCARs, argues against the necessity of a 6‐month delay, and underscores the pivotal role of oral provocation tests in the safe reintroduction of essential therapies. ABSTRACT Background Identifying and discontinuing the offending drug(s) in severe cutaneous adverse
Zohra Chadli, Khadija Mansour, Ghada Jaouahdou, Manel Ben Belgacem, Yosra Soua, Nadia Ben Fredj, Jameleddine Zili, Haifa Ben Romdhane, Karim Aouam   +8 more
wiley   +1 more source

Short-Course Chemotherapy for Tuberculosis [PDF]

, 2005
Annotated and edite transcript of a Witness Seminar held on 3 February 2004. Introduction by Dr Linda Bryder, University of Auckland.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2005. ©The Trustee of the Wellcome Trust,
Christie, DA, Tansey, EM
core