Results 41 to 50 of about 38,381 (252)

Clinical management of drug resistant tuberculosis: A comprehensive review

Asian Journal of Medical Sciences, 2014
Despite the introduction 40 years ago of the inexpensive and effective four-drug (isoniazid, rifampicin, pyrazinamide and ethambutol) treatment regimen, tuberculosis (TB) continues to cause considerable morbidity and mortality worldwide.
Arun Kumar
doaj   +1 more source

The first-line antituberculosis drugs, and their fixed-dose combination induced abnormal sperm morphology and histological lesions in the testicular cells of male mice

Frontiers in Cell and Developmental Biology, 2022
Rifampicin (RIF), Isoniazid (INH), Ethambutol (EMB), Pyrazinamide (PZA), and/or their fixed-dose combination (FDC) are extensively prescribed in the cure of Tuberculosis (TB) globally.
Adekunle A. Bakare, Victoria Y. Moses, Charles T. Beckely, Toluwani I. Oluyemi, Gift O. Ogunfeitimi, Aduragbemi A. Adelaja, Glory T. Ayorinde, Adeyinka M. Gbadebo, Olukunle S. Fagbenro, Olusegun I. Ogunsuyi, Opeoluwa M. Ogunsuyi, Olusoji Mayowa Ige   +11 more
doaj   +1 more source

The bactericidal activity of moxifloxacin in patients with pulmonary tuberculosis [PDF]

, 2003
Patients in whom acid-fast bacilli smear-positive pulmonary tuberculosis was newly diagnosed were randomized to receive 400 mg moxifloxacin, 300 mg isonaizid, or 600 mg rifampin daily for 5 days. Sixteen-hour overnight sputa collections were made for the
Bongard, E, Gillespie, SH, Gosling, RD, Kanduma, EG, Morris, RW, Nyindo, M, Sam, NE, Uiso, LO   +7 more
core   +1 more source

Drug Exposure and Susceptibility of Pyrazinamide Correlate with Treatment Response in Pyrazinamide-Susceptible Patients with Multidrug-Resistant Tuberculosis

Pharmaceutics
Exploring the influence of pyrazinamide exposure and susceptibility on treatment response is crucial for optimizing the management of multidrug-resistant tuberculosis (MDR-TB). This study aimed to investigate the association between pyrazinamide exposure,
Shulan Dong, Ge Shao, Lina Davies Forsman, Sainan Wang, Shanshan Wang, Jiayi Cao, Ziwei Bao, Judith Bruchfeld, Jan-Willem C. Alffenaar, Jia Liu, Yi Hu, Meiying Wu   +11 more
doaj   +1 more source

Synthesis and Crystal Structures of Mn(II) and Co(II) Complexes as Catalysts for Oxidation of Cyclohexanone

Inorganics, 2022
The global demand on adipic usage in the production of plasticizers and synthetic polyamide is increasing. In line with the search for an efficient and energy-conserving way to isolate adipic acid (AA) in good yields, this paper introduces the ...
Adedibu C. Tella, Aaron Y. Isaac, Hadley S. Clayton, Adeniyi S. Ogunlaja, Aswathy T. Venugopalan, Marimuthu Prabu, Raja Thirumalaiswamy   +6 more
doaj   +1 more source

First report of multi-drug resistant tuberculosis in a systemic lupus erythematosus patient. [PDF]

, 2015
BackgroundTreatment of a multi-drug resistant tuberculosis (MDR-TB) patient is clinically challenging, requiring a minimum of 18 months of therapy. Its occurrence in a systemic lupus erythromatosus (SLE) patient may complicate management of both MDR-TB ...
Dierberg, Kerry L, Dorjee, Kunchok, Reingold, Arthur L, Sadutshang, Tsetan D   +3 more
core   +1 more source

Isolated anal tuberculosis presenting as an anal fistula in an immunocompetent child

JPGN Reports, EarlyView.
Abstract Extra‐pulmonary tuberculosis accounts for less than 15% of all tuberculosis cases, while intestinal tuberculosis accounts for less than 1% of extra‐pulmonary forms of the disease. Abdominal organ involvement is more common, but extension to the ano‐perineal region is extremely rare.
Mariam Lagrine, Rabiy Elqadiry, Houda Nassih, Aicha Bourrahouat, Imane Ait Sab   +4 more
wiley   +1 more source

Synthesis, Biological Evaluation, and In Silico Modeling of N-Substituted Quinoxaline-2-Carboxamides

Pharmaceuticals, 2021
Despite the established treatment regimens, tuberculosis remains an alarming threat to public health according to WHO. Novel agents are needed to overcome the increasing rate of resistance and perhaps achieve eradication.
Ghada Bouz, Sarah Bouz, Ondřej Janďourek, Klára Konečná, Pavel Bárta, Jarmila Vinšová, Martin Doležal, Jan Zitko   +7 more
doaj   +1 more source

Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations. [PDF]

, 2019
Fluoroquinolones represent the pillar of multidrug-resistant tuberculosis (MDR-TB) treatment, with moxifloxacin, levofloxacin, or gatifloxacin being prescribed to MDR-TB patients.
Alvarez-Cabrera, Nadine, Blanc, Landry, Dartois, Véronique, Dias-Freedman, Isabela, Dietzold, Jillian, Ho Liang, Hsin-Pin, Kaya, Firat, Kirschner, Denise, Linderman, Jennifer, Mina, Marizel, O'Brien, Paul, Pienaar, Elsje, Prideaux, Brendan, Salgame, Padmini, Sarathy, Jansy, Savic, Radojka M, Zimmerman, Matthew   +16 more
core   +2 more sources

A novel inexpensive electrochemical sensor for pyrazinoic acid as a potential tool for the identification of pyrazinamide-resistant Mycobacterium tuberculosis

International Journal of Mycobacteriology, 2018
Introduction: Tuberculosis (TB) is a significant cause of morbidity and mortality worldwide. The patient compliance with the long treatment regimens is essential for successful eradication.
Daniel Rueda, Roberto Furukawa, Patricia Fuentes, Germán Comina, Nicolás G Rey De Castro, David Requena, Robert H Gilman, Patricia Sheen, Mirko Zimic   +8 more
doaj   +1 more source