Results 51 to 60 of about 35,963 (186)

A novel inexpensive electrochemical sensor for pyrazinoic acid as a potential tool for the identification of pyrazinamide-resistant Mycobacterium tuberculosis

International Journal of Mycobacteriology, 2018
Introduction: Tuberculosis (TB) is a significant cause of morbidity and mortality worldwide. The patient compliance with the long treatment regimens is essential for successful eradication.
Daniel Rueda, Roberto Furukawa, Patricia Fuentes, Germán Comina, Nicolás G Rey De Castro, David Requena, Robert H Gilman, Patricia Sheen, Mirko Zimic   +8 more
doaj   +1 more source

Phenotypic and genotypic characterization of Mycobacterium tuberculosis pyrazinamide resistance—India, 2018–2020

Frontiers in Microbiology
Pyrazinamide (PZA) is a key first-line antituberculosis drug that plays an important role in eradicating persister Mycobacterium tuberculosis (TB) bacilli and shortening the duration of tuberculosis treatment.
Sembulingam Tamilzhalagan, Evanslin Santus Justin, Ashok Selvaraj, Karthick Venkateswaran, Arun Kumar Sivakumar, Suganthi Chittibabu, Heather P. McLaughlin, Patrick K. Moonan, Jonathan P. Smith, Sakthi Suba, Mukesh Kumar Sathya Narayanan, Christine S. Ho, Nishant Kumar, Srikanth P. Tripathy, Srikanth P. Tripathy, Siva K. Shanmugam, Patricia J. Hall-Eidson, Uma Devi Ranganathan   +17 more
doaj   +1 more source

Multidrug resistant pulmonary tuberculosis treatment regimens and patient outcomes: an individual patient data meta-analysis of 9,153 patients. [PDF]

, 2012
Treatment of multidrug resistant tuberculosis (MDR-TB) is lengthy, toxic, expensive, and has generally poor outcomes. We undertook an individual patient data meta-analysis to assess the impact on outcomes of the type, number, and duration of drugs used ...
Alfredo Ponce-de-Leon, Andrea Benedetti, Carlos Pérez-Guzmán, Carlton Evans, Carole D. Mitnick, Chen-Yuan Chiang, Chi Chiu Leung, Christophe Lange, David Ashkin, Dennis Falzon, Dick Menzies, Domingo Palmero, Donald Enarson, Eward D. Chan, Geoffrey Pasvol, Giovanni B. Migliori, Giovanni Sotgiu, H. Simon Schaaf, Helen Cox, Hye-Ryoun Kim, Jae-Joon Yim, Jamie N. Bayona, Janice Westenhouse, Jennifer Flood, Jerome Robert, Jiehui Li, Joey Lancaster, Jose Peña, José Sifuentes-Osornio, Katherine Flanagan, Kathy DeRiemer, Kwonjune J. Seung, Leah G. Jarlsberg, Lena Shah, Lia D'Ambrosio, Madhukar Pai, Marcos Burgos, Maria G. Hollm-Delgado, Maria I. D. Quelapio, Maria L. Garcia-Garcia, Mario H. Vargas, Martie Van der Walt, Masa Narita, Matthew J. Strand, Melissa Bauer, Mercedes C. Becerra, Michael D. Iseman, Monika Avendano, Neel Gandhi, Nguyen Huy Dung, Payam Tabarsi, Philly O'Riordan, Pirett Viiklepp, Reuben M. Granich, Rita Banerjee, Robert van Altena, Rosella Centis, Salmaan Keshavjee, Sarah Royce, Sergey P. Mishustin, Seung-kyu Park, Shama D. Ahuja, Sonya S. Shin, Tae Sun Shim, Thelma E. Tupasi, Timothy H. Holtz, Tjip S. Van der Werf, Vaira Leimane, Vija Riekstina, Wiel C. M. de Lange, Wing Wai Yew, Won-Jung Koh, Yuji Shiraishi   +72 more
core   +9 more sources

Design, Synthesis, Antimycobacterial Evaluation, and In Silico Studies of 3-(Phenylcarbamoyl)-pyrazine-2-carboxylic Acids

Molecules, 2017
Pyrazinamide, the first-line antitubercular drug, has been regarded the basic component of tuberculosis treatment for over sixty years. Researchers have investigated its effect on Mycobacterium tuberculosis for this long time, and as a result, new ...
Lucia Semelková, Petra Janošcová, Carlos Fernandes, Ghada Bouz, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Lucie Navrátilová, Jiří Kuneš, Martin Doležal, Jan Zitko   +10 more
doaj   +1 more source

Pengembangan Dan Validasi Metode Analisis Rifampicin Isoniazid-pirazinamid Dalam Fixed Dose Combination Dengan Metode Kromatografi Lapis Tipis-densitometri [PDF]

, 2012
Rifampicin, isoniazid (INH) and pyrazinamide are anti tuberculosis drugs (ATD) available in fixed dose combination (FDC) form. The FDC is more practical in USAge so can improve tuberculosis patient obedience in consuming the drug.
Fauziyah, L. (Laily), Prabowo, M. H. (Muhammad), Wibowo, A. (Ari)   +2 more
core   +1 more source

Role of Nigella Sativa Seeds on Pyrazinamide Induced Hepatotoxicity

Journal of Islamic International Medical College, 2019
Objective: To determine the hepatoprotective effect of Nigella sativa seeds in Pyrazinamide induced hepatic damage in albino mice. Study Design: An experimental study.
Amtul Hafeez , Akbar Waheed , Neelofar Yousaf
doaj  

Mutations in Efflux Pump Rv1258c (Tap) Cause Resistance to Pyrazinamide, Isoniazid, and Streptomycin in M. tuberculosis

Frontiers in Microbiology, 2019
Although drug resistance in Mycobacterium tuberculosis is mainly caused by mutations in drug activating enzymes or drug targets, there is increasing interest in the possible role of efflux in causing drug resistance.
Jiayun Liu, Jiayun Liu, Wanliang Shi, Shuo Zhang, Xiaoke Hao, Dmitry A. Maslov, Kirill V. Shur, Olga B. Bekker, Valery N. Danilenko, Ying Zhang   +9 more
doaj   +1 more source

Review of multidrug-resistant and extensively drug-resistant TB: global perspectives with a focus on sub-Saharan Africa [PDF]

, 2010
Tuberculosis (TB) remains a global emergency and is responsible for 1.7 million deaths annually. Widespread global misuse of isoniazid and rifampicin over three decades has resulted in emergence of the ominous spread of multidrug-resistant TB (MDR-TB ...
Abdool Karim, Amor, Balabanova, Caminero, Centers for Disease Control and Prevention, Chan, Chiang, Chiang, Chiang, Churchyard, Dheda, Dravniece, Dubrovina, Elliott, Espinal, Espinal, Espinal, Flament-Saillour, Gandhi, Gandhi, Gandhi, Goble, Grobusch, Habeenzu, Hoek, Holtz, Holtz, Iseman, Johnson, Kehinde, Kim, Kingkaew, Korenromp, Kranzer, Lalloo, Laserson, Lienhardt, Ma, Martin, Matteelli, Meskel, Migliori, Migliori, Migliori, Migliori, Migliori, Moore, Motus, O’Donnell, Pablos-Méndez, Pai, Park, Pietzka, Pillay, Quy, Saravia, Schaaf, Schaaf, Shah, Somocurcio, Sonnenberg, Sotgiu, Torun, Umubyeyi, Wallis, WHO, WHO, WHO and IUATLD, Wright, Wright, Zumla   +70 more
core   +1 more source

Drug-Resistant Tuberculosis--Current Dilemmas, Unanswered Questions, Challenges and Priority Needs [PDF]

, 2012
Tuberculosis was declared a global emergency by the World Health Organization (WHO) in 1993. Following the declaration and the promotion in 1995 of directly observed treatment short course (DOTS), a cost-effective strategy to contain the tuberculosis ...
Abubakar, Ibrahim, Atun, Rifat, Chakaya, Jeremiah, Cox, Helen, Ditiu, Lucica, Ford, Nathan, Grobusch, Martin, Hoelscher, Michael, Lawn, Stephen D., Maeurer, Markus, Marais, Ben, Mchugh, Timothy D., McNerney, Ruth, Memish, Ziad, Migliori, Giovanni-Battista, Mwaba, Peter, O'Grady, Justin, Pletschette, Michel, Ramsay, Andrew, Raviglione, Mario, Schito, Marco, Squire, S. Bertel, Swaminathan, Soumya, Zumla, Alimuddin   +23 more
core   +1 more source

New Potentially Active Pyrazinamide Derivatives Synthesized Under Microwave Conditions

Molecules, 2014
A series of 18 N-alkyl substituted 3-aminopyrazine-2-carboxamides was prepared in this work according to previously experimentally set and proven conditions using microwave assisted synthesis methodology.
Ondrej Jandourek, Martin Dolezal, Jiri Kunes, Vladimir Kubicek, Pavla Paterova, Matus Pesko, Vladimir Buchta, Katarina Kralova, Jan Zitko   +8 more
doaj   +1 more source