Results 81 to 90 of about 35,982 (205)

The Identification of Novel Mutations in ATP-Dependent Protease ClpC1 Assists in the Molecular Diagnosis of Obscured Pyrazinamide-Resistant Tuberculosis Clinical Isolates

Microorganisms
Pyrazinamide (PZA) is a key component of tuberculosis treatment, with drug resistance (PZAR) primarily related to pncA mutations. However, discordance between phenotypic resistance and conventional pncA-based molecular diagnostics challenges diagnostic ...
H. M. Adnan Hameed, Cuiting Fang, Zhiyong Liu, Yamin Gao, Shuai Wang, Xinwen Chen, Nanshan Zhong, Htin Lin Aung, Jinxing Hu, Tianyu Zhang   +9 more
doaj   +1 more source

Tuberculosis treatment in a refugee and migrant population: 20 years of experience on the Thai-Burmese border. [PDF]

, 2010
Although tuberculosis (TB) is a curable disease, it remains a major global health problem and an important cause of morbidity and mortality among vulnerable populations, including refugees and ...
Bonnet, M, Camelique, O, Guerin, P J, Hewison, C, Hsa Thaw, K, Minetti, A, Pinoges, L, Swaddiwudhipong, W, Thi, S   +8 more
core   +1 more source

Maxillofacial Squamous Cell Carcinoma With Cervical Metastasis and Tuberculous Lymphadenitis: Diagnostic Dilemmas and Clinical Insights

Cancer Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background Maxillofacial squamous cell carcinoma (SCC) typically metastasizes to lymph nodes, yet coexisting tuberculous lymphadenitis is extraordinarily rare, posing diagnostic challenges. Case A 68‐year‐old female with right maxillofacial SCC and ipsilateral lymphadenopathy underwent radical resection and selective neck dissection after ...
Xierzhati Tuerxun, Meiheriban Tuerhong, Zainure Wubulihasimu, Baihetiyaer Yimin, Maimaitituxun Tuerdi, Kai Liu   +5 more
wiley   +1 more source

Efficacy, Effectiveness, and Safety of Treatment Regimens for Histoplasmosis and Tuberculosis Coinfection in Patients With Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome: A Systematic Review With Meta‐Analysis Protocol

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background and Aims While previous publications have briefly pointed out a few alternative therapeutic interventions for the treatment of histoplasmosis and tuberculosis coinfections in patients with Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS), there are no reviews evaluating the efficacy, effectiveness ...
Beatriz Bernava Sarinho, Inajara Rotta, Tácio de Mendonça Lima, Brígida Dias Fernandes, Patricia Melo Aguiar, Marília Berlofa Visacri   +5 more
wiley   +1 more source

Fluoroquinolones and isoniazid-resistant tuberculosis: implications for the 2018 WHO guidance. [PDF]

, 2019
INTRODUCTION: 2018 World Health Organization (WHO) guidelines for the treatment of isoniazid (H)-resistant (Hr) tuberculosis recommend a four-drug regimen: rifampicin (R), ethambutol (E), pyrazinamide (Z) and levofloxacin (Lfx), with or without H ([H]RZE-
Abbara, A, Abubakar, I, Alexander, E, Baker, LV, Barrett, JC, Booth, H, Bothamley, GH, Burgess, H, Cosgrove, C, Creer, DD, Davidson, JA, Dunleavy, A, Francis, M, Grp, LINH-RTBS, Gupta, U, Hamid, S, Harris, RJ, Haselden, BM, Holden, E, Kahr, V, Kon, OM, Kunst, H, Lalor, MK, Lipman, MC, Loebinger, MR, Loutet, MG, Lozewicz, S, Lynn, W, McHugh, TD, Milburn, HJ, Mohiyuddin, T, Palchaudhuri, P, Perrin, FM, Phillips, PPJ, Rahman, A, Schmok, E, Soobratty, MR, Stagg, HR, Taylor, L   +38 more
core   +4 more sources

Genetic Diversity and Drug Susceptibility Profiles of Multidrug-Resistant Tuberculosis Strains in Southeast China

Infection and Drug Resistance, 2021
Shufang Lin,1 Shuzhen Wei,1 Yong Zhao,1 Zhisong Dai,1 Jian Lin,1 Yu Pang2 1Fujian Provincial Key Laboratory of Zoonosis Research, Fujian Center for Disease Control and Prevention, Fuzhou, People’s Republic of China; 2Department of Bacteriology and ...
Lin S, Wei S, Zhao Y, Dai Z, Lin J, Pang Y   +5 more
doaj  

Characterization of pyrazinamide resistance in consecutive multidrug-resistant mycobacterium tuberculosis isolates in sweden between 2003 and 2015

International Journal of Mycobacteriology, 2017
Background: The first line anti-tuberculosis drug pyrazinamide (PZA) is important when treating PZA susceptible multidrug-resistant tuberculosis (MDR-TB). Several drug resistance surveys have however reported PZA resistance among a significant proportion
Mikael Mansjo, Jim Werngren, Sven Hoffner   +2 more
doaj   +1 more source

Resistance To First-Line Antituberculosis Drugs And Prevalence Of pncA Mutations In Clinical Isolates Of Mycobacterium tuberculosis From Zunyi, Guizhou Province Of China

Infection and Drug Resistance, 2019
Zhimin Cao,1 Yuanbo Lan,1 Ling Chen,1 Min Xiang,1 Zhiyuan Peng,1 Jianyong Zhang,1 Hong Zhang1,2 1Tuberculosis Division, Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, People ...
Cao Z, Lan Y, Chen L, Xiang M, Peng Z, Zhang J, Zhang H   +6 more
doaj  

Shorter treatment for minimal tuberculosis (TB) in children (SHINE): A study protocol for a randomised controlled trial [PDF]

, 2018
BACKGROUND: Tuberculosis (TB) in children is frequently paucibacillary and non-severe forms of pulmonary TB are common. Evidence for tuberculosis treatment in children is largely extrapolated from adult studies.
Aarnoutse, R, Balaji, S, Bhavani, PK, Chabala, C, Cotton, M, Crook, AM, Demers, A-M, Gibb, DM, Hesseling, A, Hissar, S, Hoddinott, G, Kapasa, M, Kinikar, A, Mave, V, McIlleron, H, Mulenga, V, Musoke, P, Owen-Powell, E, Palmer, M, Raichur, PA, SHINE trial team,, Thomason, MJ, Turkova, A, van der Zalm, M, Wobudeya, E   +24 more
core   +3 more sources

Evolutionary Genetic Analysis of the Pyrazinamidase Gene in Seven Global Populations of Mycobacterium tuberculosis

International Journal of Mycobacteriology
Background: This study aims to identify the signatures of natural selection in the pyrazinamidase (pncA) gene to see if genetic adaptations by Darwinian natural selection have shaped genetic composition of Mycobacterium tuberculosis (Mtb).
Neha Kumari, Nikhat Khan, Aparup Das
doaj   +1 more source