PharmaceuticsExploring the influence of pyrazinamide exposure and susceptibility on treatment response is crucial for optimizing the management of multidrug-resistant tuberculosis (MDR-TB). This study aimed to investigate the association between pyrazinamide exposure, susceptibility, and response to MDR-TB treatment, as well as find clinical thresholds for ...
Shulan Dong +11 more
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Emerging Microbes and InfectionsThis study investigates the epidemic trend of pyrazinamide (PZA)-resistant tuberculosis in Southern China over 11 years (2012–2022) and evaluates the mutation characteristics of PZA resistance-related genes (pncA, rpsA, and panD) in clinical ...
Nan Wang +17 more
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Performance of Wayne assay for detection of pyrazinamide resistance in Mycobacterium tuberculosis: a meta-analysis study. [PDF]
New Microbes New Infect, 2021 Nasiri MJ +7 more
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Pyrazinamide Drug Resistance in Mycobacterium Tuberculosis: A Minireview
Journal of Bacteriology & Mycology: Open Access, 2016 Pyrazinamide (PZA) is a nicotinamide analog that is used as a frontline drug to treat tuberculosis (TB). It has special place in modern TB therapy, as it appears to kill a population of semi dormant tubercle bacilli persisting in the body. It is important drug because of its sterilizing activity against semi dormant tubercle bacilli. Although PZA has a
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Phenotypic and molecular characterization of pyrazinamide resistance among multidrug-resistant Mycobacterium tuberculosis isolates in Ningbo, China. [PDF]
BMC Infect Dis, 2021 Che Y, Bo D, Lin X, Chen T, He T, Lin Y.
europepmc +1 more source
An explainable machine learning platform for pyrazinamide resistance prediction and genetic feature identification of Mycobacterium tuberculosis. [PDF]
J Am Med Inform Assoc, 2021 Zhang A, Teng L, Alterovitz G.
europepmc +1 more source
Structural and Genomic Insights Into Pyrazinamide Resistance in <i>Mycobacterium tuberculosis</i> Underlie Differences Between Ancient and Modern Lineages. [PDF]
Front Mol Biosci, 2021 Tunstall T +4 more
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Pyrazinamide is a potent sterilising agent that shortens the treatment duration needed to cure tuberculosis. It is synergistic with novel and existing drugs for tuberculosis.
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Molecular characterization of pyrazinamide resistance in Mycobacterium tuberculosis
, 2015 Tuberculosis (TB) is a highly infectious disease that causes the second highest mortality rate in human worldwide. The emergence of multi-drug resistance tuberculosis (MDR-TB) leads to a major public health problem in controlling TB-caused mortality. Pyrazinamide (PZA) is an important first-line drug in the treatment of MDR-TB.
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Binbin Liu,1,* Pan Su,1,* Peilei Hu,1,* Mi Yan,1 Wenbin Li,1 Songlin Yi,1 Zhenhua Chen,1 Xiaoping Zhang,1 Jingwei Guo,1 Xiaojie Wan,1 Jue Wang,1 Daofang Gong,1 Hua Bai,1 Kanglin Wan,2 Haican Liu,2 Guilian Li,2 Yunhong Tan1 1Clinical ...
Yan M +16 more
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