Results 111 to 120 of about 2,204,307 (197)

First-line drug-resistant tuberculosis among children under 15 years in Ethiopia: insights from phenotypic and whole-genome sequencing approaches

BMC Infectious Diseases
Background Childhood drug-resistant tuberculosis is often underdiagnosed and inadequately characterized due to the paucibacillary nature of the disease.
Yeshiwork Abebaw, Abaysew Ayele, Arash Ghodousi, Dawit Hailu Alemayehu, Gebremedhin Gebremicael, Getu Diriba, Getachew Seid, Andrea Maurizio Cabibbe, Markos Abebe, Anandi Sheth, Rahel Argaw, Woldaregay Erku Abegaz   +11 more
doaj   +1 more source

A multiple genome analysis of Mycobacterium tuberculosis reveals specific novel genes and mutations associated with pyrazinamide resistance

BMC Genomics, 2017
Background Tuberculosis (TB) is a major global health problem and drug resistance compromises the efforts to control this disease. Pyrazinamide (PZA) is an important drug used in both first and second line treatment regimes.
Patricia Sheen, David Requena, Eduardo Gushiken, Robert H. Gilman, Ricardo Antiparra, Bryan Lucero, Pilar Lizárraga, Basilio Cieza, Elisa Roncal, Louis Grandjean, Arnab Pain, Ruth McNerney, Taane G. Clark, David Moore, Mirko Zimic   +14 more
doaj   +1 more source

Prevalence of pyrazinamide resistance across the spectrum of drug resistant phenotypes of Mycobacterium tuberculosis [PDF]

, 2016
: Pyrazinamide resistance is largely unknown in the spectrum of drug resistant phenotypes. We summarize data on PZA resistance in clinical isolates from South Africa.
Van Rie, Annelies, Streicher, Elizabeth M., Whitfield, Michael G., Sampson, Samantha L., Van Helden, Paul D., Simpson, John A., Dolby, Tania, Warren, Robin M.   +7 more
core   +1 more source

Genotypic characterization of pyrazinamide resistance in Mycobacterium tuberculosis isolated from Lusaka, Zambia [PDF]

, 2018
Pyrazinamide forms a core part of treatment for all types of tuberculosis (TB) in Zambia. Due to challenges associated with pyrazinamide testing, little information is available to indicate the frequency of resistance to this drug in Zambia. To determine
Georgina Mulundu, Kunda Kasakwa, Mulundu, Georgina, Solo, Eddie Samuneti, Precious Bwalya, Yukari Fukushima, Tomoyuki Yamaguchi, Kasakwa, Kunda, Bwalya, Precious, Yamaguchi, Tomoyuki, Fukushima, Yukari, Mbulo, Grace, Chie Nakajima, Yasuhiko Suzuki, Suzuki, Yasuhiko, Grace Mbulo, Eddie Samuneti Solo, Nakajima, Chie   +17 more
core   +1 more source

Global burden of bacterial antimicrobial resistance 1990-2021: a systematic analysis with forecasts to 2050 [PDF]

Background: Antimicrobial resistance (AMR) poses an important global health challenge in the 21st century. A previous study has quantified the global and regional burden of AMR for 2019, followed with additional publications that provided more detailed ...
GBD, 2021 Antimicrobial Resistance Collaborators, GBD 2021 Antimicrobial Resistance Collaborators   +1 more
core   +1 more source

Detection of Mutations in pncA in Mycobacterium tuberculosis Clinical Isolates from Nepal in Association with Pyrazinamide Resistance. [PDF]

Curr Issues Mol Biol, 2022
Shrestha D, Maharjan B, Thapa J, Akapelwa ML, Bwalya P, Chizimu JY, Nakajima C, Suzuki Y.   +7 more
europepmc   +1 more source

Quantitative ¹H Nuclear Magnetic Resonance Assay for the Rapid Detection of Pyrazinamide Resistance in Mycobacterium tuberculosis from Sputum Samples. [PDF]

J Clin Microbiol, 2023
Lopez JM, Zimic M, Vallejos K, Sevilla D, Quispe-Carbajal M, Roncal E, Rodríguez J, Rodríguez J, Antiparra R, Arteaga H, Gilman RH, Maruenda H, Sheen P.   +12 more
europepmc   +1 more source

Optimizing Pyrazinamide Use: A Low-Hanging Fruit in Improving Outcomes with Tuberculous Meningitis? Narrative Review

Infectious Diseases and Therapy
Tuberculous meningitis (TBM) disables more than a third of its sufferers. Recent research has focused on optimizing the antitubercular regimen, mainly by increasing the dosage of rifampicin. However, pyrazinamide, with higher penetration into the central
Bella Devaleenal Daniel, Leeberk Raja Inbaraj, Shanmugapriya Kumaravadivelu, Kathirvel Subramanian, Balaji Ramraj, Abi Manesh   +5 more
doaj   +1 more source

Correction: Immunological detection of pyrazine-2-carboxylic acid for the detection of pyrazinamide resistance in Mycobacterium tuberculosis. [PDF]

PLoS One, 2021
Florentini EA, Angulo N, Gilman RH, Alcántara R, Roncal E, Antiparra R, Toscano E, Vallejos K, Kirwan DE, Zimic M, Sheen P.   +10 more
europepmc   +1 more source

Cytochrome P450 2E1/Nickel-Poly(propylene imine) dendrimeric nanobiosensor for pyrazinamide - A first line TB Drug [PDF]

, 2015
>Magister Scientiae - MScThe tuberculosis (TB) disease to this day remains one of the world’s prominent killerdiseases. Pyrazinamide (PZA) is one of the most commonly prescribed anti- tuberculosis (anti-TB) drugs due to its ability to significantly ...
Zosiwe, Mlandeli Siphelele Ernest
core   +1 more source