Results 91 to 100 of about 12,743 (165)

Atypical Genetic Basis of Pyrazinamide Resistance in Monoresistant Mycobacterium tuberculosis. [PDF]

Antimicrob Agents Chemother, 2021
Modlin SJ, Marbach T, Werngren J, Mansjö M, Hoffner SE, Valafar F.   +5 more
europepmc   +1 more source

Optimizing Pyrazinamide Use: A Low-Hanging Fruit in Improving Outcomes with Tuberculous Meningitis? Narrative Review

Infectious Diseases and Therapy
Tuberculous meningitis (TBM) disables more than a third of its sufferers. Recent research has focused on optimizing the antitubercular regimen, mainly by increasing the dosage of rifampicin. However, pyrazinamide, with higher penetration into the central
Bella Devaleenal Daniel, Leeberk Raja Inbaraj, Shanmugapriya Kumaravadivelu, Kathirvel Subramanian, Balaji Ramraj, Abi Manesh   +5 more
doaj   +1 more source

The epidemiology and gene mutation characteristics of pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates in Southern China

Emerging Microbes and Infections
This study investigates the epidemic trend of pyrazinamide (PZA)-resistant tuberculosis in Southern China over 11 years (2012–2022) and evaluates the mutation characteristics of PZA resistance-related genes (pncA, rpsA, and panD) in clinical ...
Nan Wang, Fanrong Meng, Li Deng, Ling Wu, Yu Yang, Hua Li, Yuanjin Chen, Zeyou Wei, Bei Xie, Lan Gong, Qun Niu, Jie Lei, Junwen Gao, Bo Huang, Qi Wang, Xiaomin Lai, Zhihui Liu, Jinxing Hu   +17 more
doaj   +1 more source

Performance of Wayne assay for detection of pyrazinamide resistance in Mycobacterium tuberculosis: a meta-analysis study. [PDF]

New Microbes New Infect, 2021
Nasiri MJ, Fardsanei F, Arshadi M, Deihim B, Khalili F, Dadashi M, Goudarzi M, Mirsaeidi M.   +7 more
europepmc   +1 more source

Phenotypic and molecular characterization of pyrazinamide resistance among multidrug-resistant Mycobacterium tuberculosis isolates in Ningbo, China. [PDF]

BMC Infect Dis, 2021
Che Y, Bo D, Lin X, Chen T, He T, Lin Y.
europepmc   +1 more source

Pyrazinamide Drug Resistance in Mycobacterium Tuberculosis: A Minireview

Journal of Bacteriology & Mycology: Open Access, 2016
Pyrazinamide (PZA) is a nicotinamide analog that is used as a frontline drug to treat tuberculosis (TB). It has special place in modern TB therapy, as it appears to kill a population of semi dormant tubercle bacilli persisting in the body. It is important drug because of its sterilizing activity against semi dormant tubercle bacilli. Although PZA has a
openaire   +1 more source

An explainable machine learning platform for pyrazinamide resistance prediction and genetic feature identification of Mycobacterium tuberculosis. [PDF]

J Am Med Inform Assoc, 2021
Zhang A, Teng L, Alterovitz G.
europepmc   +1 more source

Drug Exposure and Susceptibility of Pyrazinamide Correlate with Treatment Response in Pyrazinamide-Susceptible Patients with Multidrug-Resistant Tuberculosis

Pharmaceutics
Exploring the influence of pyrazinamide exposure and susceptibility on treatment response is crucial for optimizing the management of multidrug-resistant tuberculosis (MDR-TB). This study aimed to investigate the association between pyrazinamide exposure, susceptibility, and response to MDR-TB treatment, as well as find clinical thresholds for ...
Shulan Dong, Ge Shao, Lina Davies Forsman, Sainan Wang, Shanshan Wang, Jiayi Cao, Ziwei Bao, Judith Bruchfeld, Jan-Willem C. Alffenaar, Jia Liu, Yi Hu, Meiying Wu   +11 more
openaire   +3 more sources

Structural and Genomic Insights Into Pyrazinamide Resistance in <i>Mycobacterium tuberculosis</i> Underlie Differences Between Ancient and Modern Lineages. [PDF]

Front Mol Biosci, 2021
Tunstall T, Phelan J, Eccleston C, Clark TG, Furnham N.   +4 more
europepmc   +1 more source

Molecular characterization of pyrazinamide resistance in Mycobacterium tuberculosis

, 2015
Tuberculosis (TB) is a highly infectious disease that causes the second highest mortality rate in human worldwide. The emergence of multi-drug resistance tuberculosis (MDR-TB) leads to a major public health problem in controlling TB-caused mortality. Pyrazinamide (PZA) is an important first-line drug in the treatment of MDR-TB.
openaire   +2 more sources