Results 91 to 100 of about 2,204,307 (197)

Evaluating the Frequency of Resistance to Pyrazinamide Among Drug-resistant Strains of Mycobacterium tuberculosis in Isfahan, Iran

, 2021
Background: Pyrazinamide is one of the most important first-line medications for the treatment of tuberculosis and an alternative intake for MDR-TB and XDR-TB patients.
Nasr-Esfahani, B., Moghim, S., Keikha, M., Salehi, M.   +3 more
core   +1 more source

Adverse events in bedaquiline‐ and pretomanid‐based regimens for drug‐resistant tuberculosis from trial, implementation and pharmacovigilance studies

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2607-2623, August 2026.
Abstract The availability of safety data, particularly concerning adverse events (AEs) associated with the new shorter regimen for drug‐resistant tuberculosis (TB) containing a bedaquiline–pretomanid‐based regimen, is still limited. This systematic review aims to provide a comprehensive and updated analysis of AEs related to this new regimen by ...
Nisa Maria, Annisa Lazuardi Larasati, Indri Yuliani Hamdani, Jin‐Gun Cho, Jan‐Willem C. Alffenaar   +4 more
wiley   +1 more source

Prediction of pyrazinamide resistance in Mycobacterium tuberculosis using structure-based machine learning approaches [PDF]

Background: Pyrazinamide is one of four first-line antibiotics used to treat tuberculosis; however, antibiotic susceptibility testing for pyrazinamide is challenging.
Carter, Joshua, Walker, Timothy M, Walker, Ann, Posey, James E, Lynch, Charlotte I, Morlock, Glenn P, Peto, Timothy, Crook, Derrick, Adlard, Dylan, Fowler, Philip W, Whitfield, Michael G   +10 more
core   +1 more source

Preserved Spermatogenesis and Hormonal Function in Men Receiving a Pretomanid Regimen (BPaMZ) for Pulmonary Drug‐Resistant Tuberculosis

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 501-509, August 2026.
Pretomanid is a component of the World Health Organization‐recommended treatment regimen for drug‐resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no corresponding effects were observed in nonhuman primates nor clinical hormone ...
Pauline Howell, Antonio Lombardi, William Brumskine, Lali Mikiashvili, Kim Boekelheide, Joanna Moreira, Alda Holsta, Matthew Betteridge, Lindsay Thompson, Angela Crook, Paul Bruinenberg, Maria Beumont, Eugene Sun, Francesca Conradie   +13 more
wiley   +1 more source

INSERSI GEN pncA KE DALAM PLASMID pGEM-T

Jurnal Kimia Riset, 2016
. Multidrug-resistant tuberculosis (MDR-TB) is among the most worrisome elements of the pandemic of  antibiotic resistance. As the first line drug, pyrazinamide is often used to treat TB desease so there are many case of TB resistant to pyrazinamide. The
Eli Hendrik Sanjaya
doaj   +1 more source

Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis

MedComm, Volume 7, Issue 8, August 2026.
Mycobacterium tuberculosis–host interactions and infection outcomes. Following initial infection, alveolar macrophages phagocytose the pathogen, prompting the recruitment of innate immune cells including neutrophils, NK cells, and interstitial macrophages.
Xiaojuan Zhang, Ying Liu, Yilin Hou, Hongxia Niu   +3 more
wiley   +1 more source

Sputum PCR-single-strand conformational polymorphism test for same-day detection of pyrazinamide resistance in tuberculosis patients.

, 2009
Pyrazinamide is a first-line drug for treating tuberculosis, but pyrazinamide resistance testing is usually too slow to guide initial therapy, so some patients receive inappropriate therapy.
Luz Caviedes, Mirko J. Zimic, Zimic, Mirko J, Evans, Carlton A, Ying Zhang, Patricia Sheen, Gilman, Robert H, Peña, Lizeth, Carlton A. Evans, Robert H. Gilman, Moore, David AJ, Sheen, Patricia, Caviedes, Luz, Zhang, Ying, Méndez, Melissa, David A. J. Moore   +15 more
core   +1 more source

Fistulized multidrug-resistant tuberculosis

The Pan African Medical Journal, 2017
A 21-year-old woman with no history of tuberculosis was admitted to the emergency room with an acute abdominal accompanied by fever. She underwent an emergency abdominal operation surgery and histological studies revealed a peritoneal and appendicular ...
Naoual El Omri, Fadwa Mekouar
doaj   +1 more source

Pyrazinamide Resistance Assays and Two-Month Sputum Culture Status in Patients with Multidrug-Resistant Tuberculosis

, 2019
Phenotypic drug susceptibility testing is the current "gold standard" for detecting Mycobacterium tuberculosis susceptibility to antituberculous drugs.
Becerra, Mercedes, Galea, Jerome, Calderon, Roger, Murray, Megan, Mitnick, Carole, Yataco, Rosa, Huang, Chuan-Chin, Contreras, Carmen, Zhang, Zibiao, Velásquez, Gustavo E., Lecca, Leonid   +10 more
core   +1 more source

The Phase Relationship Between the Pyrazinamide Polymorphs α and γ [PDF]

, 2019
Pyrazinamide is an active pharmaceutical compound for the treatment of tuberculosis. It possesses at least four crystalline polymorphs. Polymorphism may cause solubility problems as the case of ritonavir has clearly demonstrated; however ...
Kangli, Li, Ivo, Rietveld, Josep-Lluis, Tamarit, Maria, Barrio, Benoît, Robert, Gabin, Gbabode, Marine, Vergé-Depré   +6 more
core   +2 more sources