Results 71 to 80 of about 14,172 (227)

The Patterns of Conversion to Anti-Tuberculosis Drug Resistance in Mycobacterium tuberculosis

Korean Journal of Clinical Laboratory Science, 2022
The prevalence of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) are increasing. We analyzed the patterns of drug resistance and tracking period days of acquiring anti-mycobacterial resistance.
Moo-Sang Chong, Kyutaeg Lee
doaj   +1 more source

Molecular investigation against the resistant mechanism of PncA mutated pyrazinamide resistance and insight into the role of pH environment for pyrazinamide activation

Journal of Biomolecular Structure and Dynamics, 2019
Pyrazinamide (PZA), a crucial component of anti-TB therapy, is a prodrug. PZA interacts with PncA protein to be converted into its functional form i.e. pyrazinoic acid (POA). It has unique feature to kill dormant tubercle bacilli of acidic environment.
Gaurava Srivastava, M. P. Darokar, Ashok Sharma   +2 more
openaire   +2 more sources

Comparison of the Efficacy and Prognosis of Different Treatment Strategies for Spinal Tuberculosis Patients Undergoing Vertebral Augmentation Surgery by Mistake

Orthopaedic Surgery, EarlyView.
Based on the clinical characteristics of patients with spinal tuberculosis after percutaneous vertebral augmentation, the corresponding diagnosis and treatment strategies were explored, and clinical data for the differential diagnosis of spinal tuberculosis were provided.
Xiong Xu, Yatao Wang, Litao Li, Zhanpeng Luo, Ning Liu, Yunfeng Wu, Cunshuo Wang, Bo Wang, Enning Cui, Long Yu, Xu Cui   +10 more
wiley   +1 more source

Population-based resistance of Mycobacterium tuberculosis isolates to pyrazinamide and fluoroquinolones : results from a multicountry surveillance project [PDF]

, 2016
BACKGROUND : Pyrazinamide and fluoroquinolones are essential antituberculosis drugs in new rifampicin-sparing regimens. However, little information about the extent of resistance to these drugs at the population level is available.
Tahseen, Sabira, Ismail, Nazir Ahmed, Kimerling, Michael, Alikhanova, Natavan, Skrahina, Alena, Seyfaddinova, Mehriban, Omar, Shaheed V., Ruesch-Gerdes, Sabine, Ismail, Nazir, Dadu, Andrei, Andres, Sonke, Kamal, Mostofa, Gilpin, Christopher, Dreyer, Andries, Husain, Ashaque, Hasan, Rumina, Rigouts, Leen, Wells, William A., Cirillo, Daniela Maria, Weyer, Karin, Omar, Shaheed V, Hasan, Zahra, Wells, William A, Mansjo, Mikael, Raviglione, Mario C., Omar, Shaheed Vally, Hoffner, Sven, Qadeer, Ejaz, Raviglione, Mario C, Driesen, Michèle, Niemann, Stefan, Cabibbe, Andrea Maurizio, Schito, Marco, Dean, Anna S, Floyd, Katherine, Hussain, Alamdar, Zignol, Matteo, Mukadi, Ya Diul, Mvusi, Lindiwe, Dean, Anna S., Rumina, Rumina, Gerdes, Sabine Ruesch   +41 more
core   +1 more source

Altered Pharmacokinetics and Delayed Sputum Conversion in Tuberculosis Patients Co‐Infected With HIV

Tropical Medicine &International Health, EarlyView.
ABSTRACT Background HIV co‐infection affects host responses and pharmacokinetics (PK) of tuberculosis (TB) treatment. This study assessed the PK of first‐line anti‐TB drugs and clinical outcomes in patients with and without HIV co‐infection. Methods In this prospective observational study, 61 adults with sputum‐positive pulmonary TB, either confirmed ...
Aung Pyae Phyo, Richard M. Hoglund, Makoto Saito, Sein Sein Thi, Lei Lei Swe, Palang Chotsiri, Htet Ko Ko Aung, Win Pa Pa Tun, Banyar Maung Maung, Chanapat Pateekham, Wanitda Watthanaworawit, Gornpan Gornsawun, Nicholas J. White, Francois Nosten, Joel Tarning   +14 more
wiley   +1 more source

A new rapid and simple colorimetric method to detect pyrazinamide resistance in Mycobacterium tuberculosis using nicotinamide [PDF]

, 2006
OBJECTIVES: The purpose of this study was to develop and assess a rapid method for pyrazinamide resistance detection in Mycobacterium tuberculosis using nicotinamide in a colorimetric resazurin assay. METHODS: We have tested M.
Portaels, Françoise, Martin, A., Palomino, J. C., Takiff, H., Portaels, F., Palomino, Juan Carlos, Vandamme, Peter, Swings, J., Vandamme, P., Martin, Anandi, Takiff, Howard, Swings, Jean   +11 more
core   +1 more source

Resistance patterns of Mycobacterium tuberculosis isolates from pulmonary tuberculosis patients in Nairobi

Journal of Infection in Developing Countries, 2011
Introduction: In Kenya, which ranks thirteenth of 27 high tuberculosis burden countries, diagnosis is based on Ziehl-Neelsen staining alone and patients are treated without information on sensitivity patterns.
Perpetual Wangui Ndung'u, Samuel Kariuki, Zipporah Ng'ang'a, Gunturu Revathi   +3 more
doaj   +1 more source

Contezolid in the Treatment of Multidrug‐Resistant Tuberculous Meningitis: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Multidrug‐resistant tuberculous meningitis (MDR‐TBM) has a high mortality rate, and treatment options are limited. Linezolid is recommended for refractory cases but often causes intolerable adverse reactions such as peripheral neuropathy. Contezolid, a novel oxazolidinone, has shown better safety profiles in preclinical and early clinical ...
Na Wang, Xingyu Li, Qiaoyi Yan, Haitao Su, Yufeng Liu, Yanhong Li, Chunrong Yang, Yingchun Gu, Taoli Yan, Qiuzhen Wang, Xia Liu   +10 more
wiley   +1 more source

Pyrazinamide Resistance Assays and Two-Month Sputum Culture Status in Patients with Multidrug-Resistant Tuberculosis [PDF]

, 2019
Phenotypic drug susceptibility testing is the current "gold standard" for detecting Mycobacterium tuberculosis susceptibility to antituberculous drugs.
Becerra, Mercedes, Galea, Jerome, Calderon, Roger, Murray, Megan, Mitnick, Carole, Yataco, Rosa, Huang, Chuan-Chin, Contreras, Carmen, Zhang, Zibiao, Velásquez, Gustavo E., Lecca, Leonid   +10 more
core   +1 more source

The Role of Pharmacovigilance Database in Identifying Antibiotic Resistance and Inappropriate Use: An Analysis of VigiBase Reports From Lower‐Middle‐Income Countries

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 6, June 2026.
ABSTRACT Background Digital databases such as pharmacovigilance (PV) databases could provide unique opportunities to monitor trends in suspected antibiotic resistance, ineffectiveness, and misuse, extending beyond their traditional role of tracking adverse drug reactions (ADRs).
Hager Saleh, Joseph Mitchell, Cecilia Stålsby Lundborg, Megha Sharma   +3 more
wiley   +1 more source