Results 51 to 60 of about 12,743 (165)

Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis

MedComm, Volume 7, Issue 8, August 2026.
Mycobacterium tuberculosis–host interactions and infection outcomes. Following initial infection, alveolar macrophages phagocytose the pathogen, prompting the recruitment of innate immune cells including neutrophils, NK cells, and interstitial macrophages.
Xiaojuan Zhang, Ying Liu, Yilin Hou, Hongxia Niu   +3 more
wiley   +1 more source

Bifidobacterium adolescentis is resistant to pyrazinamide, isoniazid, and streptomycin

Scientific Reports
The current study aims to understand the resistance of Bifidobacterium adolescentis to different anti-tubercular drugs (first-line oral tuberculosis drugs). The bacteria were grown with anti-tubercular drugs such as isoniazid, pyrazinamide, and streptomycin to better understand the resistance phenomena.
Anagha Nellikka, Athira Cheruvari, Prasanna Vasu, Sarma Mutturi, Kammara Rajagopal   +4 more
openaire   +3 more sources

Initial resistance to companion drugs should not be considered an exclusion criterion for the shorter multidrug-resistant tuberculosis treatment regimen

International Journal of Infectious Diseases, 2020
Objectives: We investigated whether companion drug resistance was associated with adverse outcomes of the shorter multidrug-resistant tuberculosis (MDR-TB) treatment regimen in Bangladesh after adjustment for fluoroquinolone resistance.
Pauline Lempens, Tom Decroo, Kya J.M. Aung, Mohammad A. Hossain, Leen Rigouts, Conor J. Meehan, Armand Van Deun, Bouke C. de Jong   +7 more
doaj   +1 more source

Primary Tracheal Rosai‐Dorfman Disease Coexisting With Active Pulmonary Tuberculosis

Respirology Case Reports, Volume 14, Issue 8, August 2026.
We report a rare case of primary tracheal Rosai‐Dorfman disease (RDD) with active pulmonary tuberculosis. Bronchoscopic resection immediately relieved > 90% airway obstruction, and anti‐tuberculosis therapy was given, resulting in no recurrence at one‐year follow‐up. ABSTRACT Rosai‐Dorfman disease (RDD) rarely involves the trachea, and active pulmonary
Shijie Yang, Shaoling Li, Wenwen Sun, Ye Gu, Li Yang   +4 more
wiley   +1 more source

Effects of mutations conferring pyrazinamide resistance among multidrug-resistant tuberculosis isolates from China

Microbiology Spectrum
To investigate the effects of mutations on pyrazinamide (PZA)-associated regions, including pncA, rpsA, panD, and clpC1, among multidrug-resistant tuberculosis (MDR-TB) isolates from China.
Xiang-long Bo, Ma-chao Li, Hao Hang, Shi-qiang Lin, Hai-can Liu, Cheng Qian, Gui-lian Li, Xiu-qin Zhao, Kang-Lin Wan, Li-li Zhao   +9 more
doaj   +1 more source

Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data.

PLoS Medicine, 2020
BackgroundThe surveillance of drug resistance among tuberculosis (TB) patients is central to combatting the global TB epidemic and preventing the spread of antimicrobial resistance. Isoniazid and rifampicin are two of the most powerful first-line anti-TB
Anna S Dean, Matteo Zignol, Andrea Maurizio Cabibbe, Dennis Falzon, Philippe Glaziou, Daniela Maria Cirillo, Claudio U Köser, Lice Y Gonzalez-Angulo, Olga Tosas-Auget, Nazir Ismail, Sabira Tahseen, Maria Cecilia G Ama, Alena Skrahina, Natavan Alikhanova, S M Mostofa Kamal, Katherine Floyd   +15 more
doaj   +1 more source

Comparison of the Efficacy and Prognosis of Different Treatment Strategies for Spinal Tuberculosis Patients Undergoing Vertebral Augmentation Surgery by Mistake

Orthopaedic Surgery, Volume 18, Issue 8, Page 1631-1640, August 2026.
Based on the clinical characteristics of patients with spinal tuberculosis after percutaneous vertebral augmentation, the corresponding diagnosis and treatment strategies were explored, and clinical data for the differential diagnosis of spinal tuberculosis were provided.
Xiong Xu, Yatao Wang, Litao Li, Zhanpeng Luo, Ning Liu, Yunfeng Wu, Cunshuo Wang, Bo Wang, Enning Cui, Long Yu, Xu Cui   +10 more
wiley   +1 more source

A Global Perspective on Pyrazinamide Resistance: Systematic Review and Meta-Analysis [PDF]

PLOS ONE, 2015
BackgroundPyrazinamide (PZA) is crucial for tuberculosis (TB) treatment, given its unique ability to eradicate persister bacilli. The worldwide burden of PZA resistance remains poorly described.MethodsSystematic PubMed, Science Direct and Scopus searches for articles reporting phenotypic (liquid culture drug susceptibility testing or pyrazinamidase ...
Whitfield, MG, Soeters, HM, Warren, RM, York, T, Sampson, SL, Streicher, EM, Van Helden, PD, Van Rie, A   +7 more
openaire   +5 more sources

Coexisting Pyogenic and Tuberculous Liver Abscess in Uncontrolled Diabetes: A Diagnostic Challenge

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Hepatic tuberculosis can mimic pyogenic liver abscess, particularly in patients with uncontrolled diabetes. Persistent or atypical hepatic lesions unresponsive to antibiotics should prompt tissue diagnosis using histopathology and molecular assays like GeneXpert to ensure timely diagnosis and appropriate management.
Hamna Mehfooz, Azba Israr, Syed Hassan Tanvir Ramzi, Akram Malik, Syed Muhammad Salman Hassan, Sarim Hassan Shahab, Fazal Habib   +6 more
wiley   +1 more source

The molecular basis of resistance to isoniazid, rifampin, and pyrazinamide in Mycobacterium tuberculosis [PDF]

Respiratory Research, 2001
Multidrug-resistant (MDR) strains of Mycobacterium tuberculosis have emerged worldwide. In many countries and regions, these resistant strains constitute a serious threat to the efficacy of tuberculosis control programs. An important element in gaining control of this epidemic is developing an understanding of the molecular basis of resistance to the ...
Parsons Linda M, Somoskovi Akos, Salfinger Max   +2 more
openaire   +3 more sources