Results 51 to 60 of about 14,172 (227)

Evaluation of colorimetric methods using nicotinamide for rapid detection of pyrazinamide resistance in Mycobacterium tuberculosis [PDF]

, 2010
The direct detection of pyrazinamide resistance in Mycobacterium tuberculosis is sufficiently difficult so that many laboratories don't attempt it. Most pyrazinamide resistance is caused by mutations that inactivate the pyrazinamidase enzyme needed to ...
Yoslaine Milián, Lemus, Dihadenys, Madruga, Mariela, Anandi Martin, Madruga, M., Palomino, J. C., Palomino, Juan Carlos, Lemus, D., Martin, Anandi, Mirabal, Niuris C, Howard Takiff, Takiff, H., Sergio L. Yzquierdo, Van Der Stuyft, Patrick, Mirabal, N. C., Yzquierdo, S. L., Milian, Yoslaine, Ernesto Montoro, Echemendia, Miguel, Van der Stuyft, P., Milián, Y., Niuris C. Mirabal, Takiff, Howard, Dihadenys Lemus, Martin, A., Montoro, Ernesto, Echemendía, M., Mariela Madruga, Patrick Van der Stuyf, Miguel Echemendía, Juan Carlos Palomino, Montoro, E., Yzquierdo, Sergio L   +32 more
core   +1 more source

Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis

mBio, 2022
Pyrazinamide (PZA) plays a crucial role in first-line tuberculosis drug therapy. Unlike other antimicrobial agents, PZA is active against Mycobacterium tuberculosis only at low pH. The basis for this conditional drug susceptibility remains undefined.
Joshua M. Thiede, Nicholas A. Dillon, Michael D. Howe, Ranee Aflakpui, Samuel J. Modlin, Sven E. Hoffner, Faramarz Valafar, Yusuke Minato, Anthony D. Baughn   +8 more
doaj   +1 more source

Impact of genotypic and phenotypic resistance to second-line anti-tuberculosis drugs on treatment outcomes in multidrug-resistant tuberculosis in China

International Journal of Mycobacteriology, 2016
Background: Despite the strong association between drug resistance and genetic mutations, the value of molecular diagnosis of drug resistance to guide the treatment of multidrug-resistant tuberculosis (MDR-TB) remains unclear.
Yi Hu, Xubin Zheng, Zhu Ning, Qun Li, Zhengdong Zhang, Sven Hoffner   +5 more
doaj   +1 more source

Prediction of Mycobacterium tuberculosis pyrazinamidase function based on structural stability, physicochemical and geometrical descriptors.

PLoS ONE, 2020
BackgroundPyrazinamide is an important drug against the latent stage of tuberculosis and is used in both first- and second-line treatment regimens.
Rydberg Roman Supo-Escalante, Aldhair Médico, Eduardo Gushiken, Gustavo E Olivos-Ramírez, Yaneth Quispe, Fiorella Torres, Melissa Zamudio, Ricardo Antiparra, L Mario Amzel, Robert H Gilman, Patricia Sheen, Mirko Zimic   +11 more
doaj   +1 more source

Antimicrobial drug resistant features of Mycobacterium tuberculosis associated with treatment failure.

PLoS ONE, 2023
Tuberculosis stands as a prominent cause of mortality in developing countries. The treatment of tuberculosis involves a complex procedure requiring the administration of a panel of at least four antimicrobial drugs for the duration of six months.
Fizza Mushtaq, Syed Mohsin Raza, Adeel Ahmad, Hina Aslam, Atiqa Adeel, Sidrah Saleem, Irfan Ahmad   +6 more
doaj   +1 more source

Evaluating the Frequency of Resistance to Pyrazinamide Among Drug-resistant Strains of Mycobacterium tuberculosis in Isfahan, Iran [PDF]

, 2021
Background: Pyrazinamide is one of the most important first-line medications for the treatment of tuberculosis and an alternative intake for MDR-TB and XDR-TB patients.
Nasr-Esfahani, B., Moghim, S., Keikha, M., Salehi, M.   +3 more
core   +1 more source

Investigation of variations of pyrazinamide resistance and gene Xpert-based molecular typing in tuberculosis patients [PDF]

, 2023
The morbidity, death, and medication resistance caused by Mycobacterium tuberculosis are global health concern. The Gene Xpert is employed to diagnose TB early and find pyrazinamide (PYR) resistance at the same time.
Khan, Shahzaib, Naseem, Riffat, Israr, Muhammad, Yousuf, Muhammad, Abid, Hafiz Zia Ullah, Aarab, Muhammad   +5 more
core   +2 more sources

Resistance to first- and second-line antituberculosis drugs in Southern Taiwan: Implications for empirical treatment

Journal of Microbiology, Immunology and Infection, 2018
Background: Multidrug-resistant and extensively drug-resistant tuberculosis infections cause public health concerns worldwide. Local epidemiologic data about the drug resistance of Mycobacterium tuberculosis isolate (Mtb) is critical to guide appropriate
Cheng-Yu Kuo, Wen-Hung Wang, Chung-Hao Huang, Yen-Hsu Chen, Po-Liang Lu   +4 more
doaj   +1 more source

Effect of pyrazinamidase activity on pyrazinamide resistance in Mycobacterium tuberculosis [PDF]

Tuberculosis, 2009
Resistance of Mycobacterium tuberculosis to pyrazinamide is associated with mutations in the pncA gene, which codes for pyrazinamidase. The association between the enzymatic activity of mutated pyrazinamidases and the level of pyrazinamide resistance remains poorly understood. Twelve M.
Patricia, Sheen, Patricia, Ferrer, Robert H, Gilman, Jon, López-Llano, Patricia, Fuentes, Eddy, Valencia, Mirko J, Zimic   +6 more
openaire   +2 more sources

Pyrazinamide may possess cardioprotective properties [PDF]

, 2019
Pyrazinamide is an anti-tubercular agent, used as a part of a three-drug regime (any three of the following: rifampicin, isoniazid, pyrazinamide, streptomycin or ethambutol) for the initial phase of treatment.
Sukhodub, Andriy, Du, Qingyou, Sinha, Sharabh, Sofija Jovanović, Jovanovic, Sofija, Aleksandar Jovanović, Sharabh Sinha, Andriy Sukhodub, Qingyou Du, Jovanović, Aleksandar   +9 more
core   +1 more source