Results 51 to 60 of about 2,204,307 (197)

Exploring of pyrazinamidase recombinant activity from PZA-sensitive and resistant Mycobacterium tuberculosis expressed in Escherichia coli BL21 (DE3) [PDF]

Brazilian Journal of Biology
The mutations of pncA gene encoding pyrazinamidase/PZase in Mycobacterium tuberculosis are often associated with pyrazinamide/PZA resistance. The H and R1 isolates showed significant phenotypic differences to PZA.
P. Purkan, S. Hadi, W. Retnowati, S. Sumarsih, D. K. Wahyuni, B. Piluharto, T. M. Panjaitan, C. Ifada, A. Nadila, B. A. Nabilah   +9 more
doaj   +1 more source

Prevalence and transmission of pyrazinamide resistant Mycobacterium tuberculosis in China [PDF]

Tuberculosis, 2016
Pyrazinamide (PZA) is an important first-line anti-tuberculosis drug, however, there are relatively few available data on PZA resistant (PZA-R) rate in China. From June 2009 to June 2012, we selected 493 isolates from five field settings in China to investigate PZA-R by pncA gene sequencing.
Peng, Xu, Jie, Wu, Chongguang, Yang, Tao, Luo, Xin, Shen, Yangyi, Zhang, Chijioke A, Nsofor, Guofeng, Zhu, Brigitte, Gicquel, Qian, Gao   +9 more
openaire   +2 more sources

Mutations conferring resistance to first-line anti-tuberculosis drugs in Peru: a systematic review of the literature

Revista Peruana de Medicina Experimental y Salud Pública, 2019
Objective. To systematize available information regarding mutations that confer resistance to first-line anti-tuberculosis drugs. Materials and Methods.
Aiko Vigo, Lely Solari, David Santos, Zully M. Puyén   +3 more
doaj   +1 more source

Characterization of pyrazinamide resistance in consecutive multidrug-resistant mycobacterium tuberculosis isolates in sweden between 2003 and 2015

International Journal of Mycobacteriology, 2017
Background: The first line anti-tuberculosis drug pyrazinamide (PZA) is important when treating PZA susceptible multidrug-resistant tuberculosis (MDR-TB). Several drug resistance surveys have however reported PZA resistance among a significant proportion
Mikael Mansjo, Jim Werngren, Sven Hoffner   +2 more
doaj   +1 more source

The Patterns of Conversion to Anti-Tuberculosis Drug Resistance in Mycobacterium tuberculosis

Korean Journal of Clinical Laboratory Science, 2022
The prevalence of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) are increasing. We analyzed the patterns of drug resistance and tracking period days of acquiring anti-mycobacterial resistance.
Moo-Sang Chong, Kyutaeg Lee
doaj   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Role of rpsA Gene Sequencing in Diagnosis of Pyrazinamide Resistance [PDF]

Journal of Clinical Microbiology, 2013
We read with great interest the article by Alexander and colleagues ([1][1]) on the frequency of rpsA mutations in pyrazinamide-susceptible and resistant isolates with a wild-type pncA gene. In contrast to the report of Shi and colleagues ([2][2]), Alexander and colleagues could not find any ...
Simons, SO, Mulder, A, van Ingen, J, Boeree, MJ, van Soolingen, D   +4 more
openaire   +5 more sources

Patterns of Drug Resistance, Drug Resistance Conferring Mutations and Genomic DNA Methylation Revealed in Mycobacterium tuberculosis From South Africa

Tropical Medicine &International Health, EarlyView.
ABSTRACT Tuberculosis remains a major public health threat globally, with drug‐resistant strains undermining treatment efficacy. We analyzed 126 Mycobacterium tuberculosis (M. tuberculosis) isolates with diverse drug resistance spectra and selected 35 for whole genome sequencing (WGS) using Illumina NextSeq, SMRT PacBio Onso and SMRT PacBio Revio ...
Unarine Matodzi, Awelani Mutshembele, Eric Mensah, Dillon Muzondiwa, Ndivhuho A. Makhado, Oleg N. Reva   +5 more
wiley   +1 more source

Investigation of variations of pyrazinamide resistance and gene Xpert-based molecular typing in tuberculosis patients [PDF]

, 2023
The morbidity, death, and medication resistance caused by Mycobacterium tuberculosis are global health concern. The Gene Xpert is employed to diagnose TB early and find pyrazinamide (PYR) resistance at the same time.
Khan, Shahzaib, Naseem, Riffat, Israr, Muhammad, Yousuf, Muhammad, Abid, Hafiz Zia Ullah, Aarab, Muhammad   +5 more
core   +1 more source

Resistance patterns of Mycobacterium tuberculosis isolates from pulmonary tuberculosis patients in Nairobi

Journal of Infection in Developing Countries, 2011
Introduction: In Kenya, which ranks thirteenth of 27 high tuberculosis burden countries, diagnosis is based on Ziehl-Neelsen staining alone and patients are treated without information on sensitivity patterns.
Perpetual Wangui Ndung'u, Samuel Kariuki, Zipporah Ng'ang'a, Gunturu Revathi   +3 more
doaj   +1 more source