Determination of pyrazinamide plasma concentrations using lc-ms and pharmacokinetics of pyrazinamide in patients with multidrug-resistant tuberculosis and in patients co-infected with multidrug-resistant tuberculosis and HIV [PDF]
, 2013 Magister Pharmaceuticae - MPharmTuberculosis and HIV are arguably South Africa’s largest and most important health issues. With drug-resistant strains of tuberculosis on the increase and little research on new drugs, there is an urgent need for research ...
Botha, Carla Ilse
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Effect of pyrazinamidase activity on pyrazinamide resistance in Mycobacterium tuberculosis [PDF]
Tuberculosis, 2009 Resistance of Mycobacterium tuberculosis to pyrazinamide is associated with mutations in the pncA gene, which codes for pyrazinamidase. The association between the enzymatic activity of mutated pyrazinamidases and the level of pyrazinamide resistance remains poorly understood. Twelve M.
Patricia, Sheen +6 more
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Detection of Mycobacterium Tuberculosis Resistance to Pyrazinamide Antibiotic Using Polymerase Chain Reaction (PCR) Technique [PDF]
, 2022 The tuberculosis treatment control program is constrained by the outbreak of TB that is resistant to anti-tuberculosis drugs (OAT), especially multidrug-resistant tuberculosis.
Kurniawan, Edy, Halid, Idham
core
Pathogens, 2019 Pyrazinamide (PZA) is a key drug for tuberculosis treatment. The active form of PZA, pyrazinoic acid (POA), appears to inhibit multiple targets in M. tuberculosis. Recently, the bifunctional enzyme Rv2783 was reported as a new target of POA. However, the
Lei He +6 more
doaj +1 more source
Insight to pyrazinamide resistance in Mycobacterium tuberculosis by molecular docking [PDF]
Bioinformation, 2009 Pyrazinamide (PZA) - an important drug in the anti-tuberculosis therapy, activated by an enzyme Pyrazinamidase (PZase). The basis of PZA resistance in Mycobacterium tuberculosis was owing to mutation in pncA gene coding for PZase. Homology modeling of PZase was performed using software Discovery Studio (DS) 2.0 based on the crystal structure of the ...
Unissa, A N, Selvakumar, N, Hassan, S
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Pyrazinamide may possess cardioprotective properties [PDF]
, 2019 Pyrazinamide is an anti-tubercular agent, used as a part of a three-drug regime (any three of the following: rifampicin, isoniazid, pyrazinamide, streptomycin or ethambutol) for the initial phase of treatment.
Sukhodub, Andriy +9 more
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BMC Infectious Diseases, 2021 Background Multidrug-resistant tuberculosis (MDR-TB) are unsatisfied to treat, pressing more effective and innovative treatment regimens. New efficient regimens for MDR-TB have obtained high treatment success rates.
Taoping Weng +8 more
doaj +1 more source
Nitrate reductase assay for the rapid detection of pyrazinamide resistance in Mycobacterium tuberculosis using nicotinamide [PDF]
, 2008 OBJECTIVES: The purpose of this study was to develop the nitrate reductase assay (NRA) for the rapid detection of pyrazinamide resistance in Mycobacterium tuberculosis using nicotinamide resistance as a marker of pyrazinamide resistance in Löwenstein ...
Palomino, J. C. +13 more
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Pyrazinamide-3-Nitrophthalic Acid Cocrystals: Synthesis, Transformation, and Property Evaluation
, 2023 The generation of multiple stoichiometric cocrystals from safe and nontoxic water is a rare occurrence. This study explored three different stoichiometric cocrystals (1:1, 1:2, and 2:1) of pyrazinamide-3-nitrophthalic acid cocrystals characterized by ...
Xiaohan Li (276434) +6 more
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Journal of Biomolecular Structure and Dynamics, 2019 Pyrazinamide (PZA), a crucial component of anti-TB therapy, is a prodrug. PZA interacts with PncA protein to be converted into its functional form i.e. pyrazinoic acid (POA). It has unique feature to kill dormant tubercle bacilli of acidic environment.
Gaurava Srivastava +2 more
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