Results 41 to 50 of about 14,172 (227)

Counting Pyrazinamide in Regimens for Multidrug-Resistant Tuberculosis [PDF]

Annals of the American Thoracic Society, 2015
Abstract Rationale For treatment of multidrug-resistant tuberculosis, World Health Organization (WHO) guidelines recommend four likely effective drugs plus pyrazinamide (PZA), irrespective of the likely effectiveness of PZA in an individual patient.
Molly F, Franke, Mercedes C, Becerra, Dylan B, Tierney, Michael L, Rich, Cesar, Bonilla, Jaime, Bayona, Megan M, McLaughlin, Carole D, Mitnick   +7 more
openaire   +2 more sources

Mutations Associated with Pyrazinamide Resistance in the Clinical Isolates of Mycobacterium tuberculosis [PDF]

, 2013
Pyrazinamide is one of the four first line drugs for treatment of tuberculosis. It has been widely accepted, that pyrazinamide (PZA) resistance in Mycobacterium tuberculosis is correlated with mutations in the pncA gene.
AK Anilkumar GK Madhavilatha
openalex   +3 more sources

The study of cross-resistance of MTB to certain anti-tuberculosis drugs among tuberculosis patients in Tomsk Region

Туберкулез и болезни лёгких, 2020
The objective of the study: to assess the prevalence of drug resistance of tuberculous mycobacteria (MTB) to pyrazinamide, linezolid, cross-resistance to fluoroquinolones, and cross-resistance to injectable anti-tuberculosis drugs among tuberculosis ...
P. N. Golubchikov, E. A. Kruk, S. P. Mishustin, V. E. Pavlova, D. Yu. Schegertsov, A. S. Аlliluev   +5 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Molecular characterization of pyrazinamide resistance in Mycobacterium tuberculosis

, 2013
Tuberculosis (TB) is a highly infectious disease that causes the second highest mortality rate in human worldwide. The emergence of multi-drug resistance tuberculosis (MDR-TB) leads to a major public health problem in controlling TB-caused mortality. Pyrazinamide (PZA) is an important first-line drug in the treatment of MDR-TB.
Wai-ting Ko
openalex   +3 more sources

Pyrazinamide resistance in Mycobacterium tuberculosis fails to bite? [PDF]

Pathogens and Disease, 2015
In contrast to most other antimycobacterial drugs where--particularly in multidrug-resistant (MDR) strains--a limited number of resistance mutations dominate, pyrazinamide (PZA) resistance associated mutations remain highly diverse with limited clustering.
Alice L. den Hertog, Sarah Sengstake, Richard Anthony   +2 more
openalex   +3 more sources

Impact of pyrazinamide resistance on multidrug-resistant tuberculosis in Karakalpakstan, Uzbekistan [PDF]

The International Journal of Tuberculosis and Lung Disease, 2018
The World Health Organization (WHO) recommends the inclusion of pyrazinamide (PZA) in treatment regimens for multidrug-resistant tuberculosis (MDR-TB) unless resistance has been confirmed.To investigate the association between PZA susceptibility and MDR-TB treatment outcome among patients treated with a PZA-containing regimen and whether the duration ...
Kuhlin, J, Smith, C, Khaemraev, A, Tigay, Z, Parpieva, N, Tillyashaykhov, M, Achar, J, Hajek, J, Greig, J, du Cros, P, Moore, D   +10 more
openaire   +2 more sources

Analysis of rpoB and pncA mutations in the published literature: an insight into the role of oxidative stress in Mycobacterium tuberculosis evolution? [PDF]

, 2005
Introduction: It is perceived wisdom that within the host macrophage, Mycobacterium tuberculosis frequently encounters oxidative stress. Exposure of bacteria to reactive oxygen intermediates can have a mutagenic effect on the DNA.
O'Sullivan, DM, O'Sullivan, D M, McHugh, TD, Timothy D. McHugh, O'Sullivan, Denise M, Gillespie, S H, Gillespie, Stephen H, Gillespie, SH, Stephen H. Gillespie, McHugh, Timothy D, Denise M. O'Sullivan, McHugh, T D   +11 more
core   +1 more source

Programmatically selected multidrug-resistant strains drive the emergence of extensively drug-resistant tuberculosis in South Africa [PDF]

, 2013
South Africa shows one of the highest global burdens of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). Since 2002, MDR-TB in South Africa has been treated by a standardized combination therapy, which until 2010 included
Pillay, Manormoney, van Helden, Paul D., Nicolaas C. Gey van Pittius (173264), Paul D. van Helden (33594), Marlein E Bosman, Gagneux, Sebastien, Thomas C Victor, Manormoney Pillay (257769), Nicolaas C Gey van Pittius, Borna Müller (173253), Hayes, Cindy, Streicher, Elizabeth M., Andre Trollip (449922), Robin M Warren, Elizabeth M Streicher, Trollip, Andre, Violet N. Chihota (143307), Warren, Robin M., Bosman, Marlein E., Müller, Borna, Violet N Chihota, Cindy Hayes, Marisa Klopper (398815), Cindy Hayes (449923), Elizabeth M. Streicher (439727), Borna Müller, Paul D van Helden, Marlein E. Bosman (449924), Klopper, Marisa, Gerrit Coetzee, Sebastien Gagneux (149824), Chihota, Violet N., Andre Trollip, Marisa Klopper, Sebastien Gagneux, Gerrit Coetzee (296078), Victor, Thomas C., Manormoney Pillay, Coetzee, Gerrit, Gey van Pittius, Nicolaas C., Robin M. Warren (33593), Thomas C. Victor (185348)   +41 more
core   +1 more source

Activity of n-propyl pyrazinoate against pyrazinamide-resistant Mycobacterium tuberculosis: investigations into mechanism of action of and mechanism of resistance to pyrazinamide [PDF]

Antimicrobial Agents and Chemotherapy, 1995
The mechanism of action of pyrazinamide (PZA) is not known. One hypothesis is that PZA functions as a prodrug of pyrazinoic acid. Susceptibility to PZA correlates with amidase activity of the Mycobacterium tuberculosis isolate in question. PZA-resistant isolates retain susceptibility in vitro to pyrazinoic acid and n-propyl pyrazinoate.
R J, Speirs, J T, Welch, M H, Cynamon
openaire   +2 more sources