Prediction of pyrazinamide resistance in Mycobacterium tuberculosis using structure-based machine-learning approaches. [PDF]
JAC Antimicrob ResistBackground Pyrazinamide is one of four first-line antibiotics used to treat tuberculosis; however, antibiotic susceptibility testing for pyrazinamide is challenging.
Carter JJ +10 more
europepmc +3 more sources
Overcoming the pitfalls of automatic interpretation of whole genome sequencing data by online tools for the prediction of pyrazinamide resistance in Mycobacterium tuberculosis. [PDF]
PLoS One, 2019 Iwamoto T +11 more
europepmc +3 more sources
Sputum PCR-Single-Strand Conformational Polymorphism Test for Same-Day Detection of Pyrazinamide Resistance in Tuberculosis Patients [PDF]
, 2009 Pyrazinamide is a first-line drug for treating tuberculosis, but pyrazinamide resistance testing is usually too slow to guide initial therapy, so some patients receive inappropriate therapy.
Patricia Sheen +8 more
openalex +3 more sources
Pyrazinamide resistance in Swedish multidrug-resistant tuberculosis 2003–2013
International Journal of Mycobacteriology, 2015 Aims and objectives: The aim of this study is to determine the prevalence of pyrazinamide (PZA) resistance among multidrug-resistant Mycobacterium tuberculosis (MDR-TB) strains isolated in Sweden between 2003 and 2013 and to study the correlation between
M Mansjö, J Werngren, S Hoffner
doaj +2 more sources
Mechanisms of Pyrazinamide Action and Resistance [PDF]
Microbiology Spectrum, 2014 ABSTRACT Pyrazinamide (PZA) is a unique antituberculosis (anti-TB) drug that plays a key role in shortening TB therapy. PZA kills nonreplicating persisters that other TB drugs fail to kill, which makes it an essential drug for inclusion in any drug combinations for treating drug-susceptible and drug-resistant TB such as multidrug-
Ying, Zhang +3 more
openaire +3 more sources
Mutations and insights into the molecular mechanisms of resistance of Mycobacterium tuberculosis to first-line [PDF]
Genetics and Molecular Biology, 2023 Genetically antimicrobial resistance in Mycobacterium tuberculosis is currently one of the most important aspects of tuberculosis, considering that there are emerging resistant strains for almost every known drug used for its treatment.
Nicolas de Oliveira Rossini +1 more
doaj +1 more source
Pyrazinamide resistance of novel mutations in pncA and their dynamic behavior. [PDF]
RSC Adv, 2020 We performed several analyses to unveil the pyrazinamide-resistance mechanism of R123P, T76P, G150A, and H71R mutants through molecular dynamics simulations.
Ali A +7 more
europepmc +4 more sources
PLoS ONE, 2022 BackgroundEthiopia is one of the high multidrug-resistant tuberculosis (MDR-TB) burden countries. However, phenotypic drug susceptibility testing can take several weeks due to the slow growth of Mycobacterium tuberculosis complex (MTBC) strains.
Eyob Abera Mesfin +7 more
doaj +1 more source
Frontiers in Microbiology, 2021 Pyrazinamide (PZA) is widely used to treat drug-sensitive or multidrug resistance tuberculosis. However, conventional PZA susceptibility tests of clinical isolates are rather difficult because of the requirement of acid pH.
Kun Li +6 more
doaj +1 more source
The molecular basis of resistance to isoniazid, rifampin, and pyrazinamide in Mycobacterium tuberculosis [PDF]
Respiratory Research, 2001 Multidrug-resistant (MDR) strains of Mycobacterium tuberculosis have emerged worldwide. In many countries and regions, these resistant strains constitute a serious threat to the efficacy of tuberculosis control programs. An important element in gaining control of this epidemic is developing an understanding of the molecular basis of resistance to the ...
Ákos Somoskövi +2 more
openalex +5 more sources