Results 31 to 40 of about 2,204,307 (197)

Analysis of rpoB and pncA mutations in the published literature: an insight into the role of oxidative stress in Mycobacterium tuberculosis evolution? [PDF]

, 2005
Introduction: It is perceived wisdom that within the host macrophage, Mycobacterium tuberculosis frequently encounters oxidative stress. Exposure of bacteria to reactive oxygen intermediates can have a mutagenic effect on the DNA.
O'Sullivan, DM, O'Sullivan, D M, McHugh, TD, Timothy D. McHugh, O'Sullivan, Denise M, Gillespie, S H, Gillespie, Stephen H, Gillespie, SH, Stephen H. Gillespie, McHugh, Timothy D, Denise M. O'Sullivan, McHugh, T D   +11 more
core   +1 more source

Programmatically selected multidrug-resistant strains drive the emergence of extensively drug-resistant tuberculosis in South Africa [PDF]

, 2013
South Africa shows one of the highest global burdens of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). Since 2002, MDR-TB in South Africa has been treated by a standardized combination therapy, which until 2010 included
Pillay, Manormoney, van Helden, Paul D., Nicolaas C. Gey van Pittius (173264), Paul D. van Helden (33594), Marlein E Bosman, Gagneux, Sebastien, Thomas C Victor, Manormoney Pillay (257769), Nicolaas C Gey van Pittius, Borna Müller (173253), Hayes, Cindy, Streicher, Elizabeth M., Andre Trollip (449922), Robin M Warren, Elizabeth M Streicher, Trollip, Andre, Violet N. Chihota (143307), Warren, Robin M., Bosman, Marlein E., Müller, Borna, Violet N Chihota, Cindy Hayes, Marisa Klopper (398815), Cindy Hayes (449923), Elizabeth M. Streicher (439727), Borna Müller, Paul D van Helden, Marlein E. Bosman (449924), Klopper, Marisa, Gerrit Coetzee, Sebastien Gagneux (149824), Chihota, Violet N., Andre Trollip, Marisa Klopper, Sebastien Gagneux, Gerrit Coetzee (296078), Victor, Thomas C., Manormoney Pillay, Coetzee, Gerrit, Gey van Pittius, Nicolaas C., Robin M. Warren (33593), Thomas C. Victor (185348)   +41 more
core   +2 more sources

Mutations Associated with Pyrazinamide Resistance in the Clinical Isolates of Mycobacterium tuberculosis [PDF]

, 2021
Pyrazinamide is one of the four first line drugs for treatment of tuberculosis. It has been widely accepted, that pyrazinamide (PZA) resistance in Mycobacterium tuberculosis is correlated with mutations in the pncA gene.
GK Madhavilatha, AK Anilkumar
core   +1 more source

Activity of n-propyl pyrazinoate against pyrazinamide-resistant Mycobacterium tuberculosis: investigations into mechanism of action of and mechanism of resistance to pyrazinamide [PDF]

Antimicrobial Agents and Chemotherapy, 1995
The mechanism of action of pyrazinamide (PZA) is not known. One hypothesis is that PZA functions as a prodrug of pyrazinoic acid. Susceptibility to PZA correlates with amidase activity of the Mycobacterium tuberculosis isolate in question. PZA-resistant isolates retain susceptibility in vitro to pyrazinoic acid and n-propyl pyrazinoate.
R J, Speirs, J T, Welch, M H, Cynamon
openaire   +2 more sources

Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis

mBio, 2022
Pyrazinamide (PZA) plays a crucial role in first-line tuberculosis drug therapy. Unlike other antimicrobial agents, PZA is active against Mycobacterium tuberculosis only at low pH. The basis for this conditional drug susceptibility remains undefined.
Joshua M. Thiede, Nicholas A. Dillon, Michael D. Howe, Ranee Aflakpui, Samuel J. Modlin, Sven E. Hoffner, Faramarz Valafar, Yusuke Minato, Anthony D. Baughn   +8 more
doaj   +1 more source

Improved Bactec MGIT 960 Pyrazinamide Test Decreases Detection of False Mycobacterium tuberculosis Pyrazinamide Resistance [PDF]

Journal of Clinical Microbiology, 2017
Pyrazinamide (PZA) is a key drug for the treatment of tuberculosis (TB). Resistance to PZA is caused mostly by mutations in the pncA gene, encoding pyrazinamidase, which converts the prodrug PZA to the active form, pyrazinoic acid ([1][1], [2][2]).
Mustazzolu, Alessandro, Iacobino, Angelo, Giannoni, Federico, Piersimoni, Claudio, Fattorini, Lanfranco, Mazzola, Ester, Cichero, Paola, Lombardi, Alessandra, Libanori, Elena, Marone, Piero, Monzillo, Vincenzina, Arosio, Marco, Farina, Claudio, Peracchi, Marta, Scarparo, Claudio, Frizzera, Eliana, Pietrosemoli, Paola, Matteucci, Marina, Rindi, Laura, Luciano, Eugenio, Mencacci, Antonella, Nuzzolese, Eugenio, Vitullo, Eustachio, Dodaro, Saveria, Giraldi, Cristina, Nisticò, Salvatore, Vinci, Maria, Salvatore Podda, Giovanni   +27 more
openaire   +2 more sources

Prediction of Mycobacterium tuberculosis pyrazinamidase function based on structural stability, physicochemical and geometrical descriptors.

PLoS ONE, 2020
BackgroundPyrazinamide is an important drug against the latent stage of tuberculosis and is used in both first- and second-line treatment regimens.
Rydberg Roman Supo-Escalante, Aldhair Médico, Eduardo Gushiken, Gustavo E Olivos-Ramírez, Yaneth Quispe, Fiorella Torres, Melissa Zamudio, Ricardo Antiparra, L Mario Amzel, Robert H Gilman, Patricia Sheen, Mirko Zimic   +11 more
doaj   +1 more source

Impact of genotypic and phenotypic resistance to second-line anti-tuberculosis drugs on treatment outcomes in multidrug-resistant tuberculosis in China

International Journal of Mycobacteriology, 2016
Background: Despite the strong association between drug resistance and genetic mutations, the value of molecular diagnosis of drug resistance to guide the treatment of multidrug-resistant tuberculosis (MDR-TB) remains unclear.
Yi Hu, Xubin Zheng, Zhu Ning, Qun Li, Zhengdong Zhang, Sven Hoffner   +5 more
doaj   +1 more source

Antimicrobial drug resistant features of Mycobacterium tuberculosis associated with treatment failure.

PLoS ONE, 2023
Tuberculosis stands as a prominent cause of mortality in developing countries. The treatment of tuberculosis involves a complex procedure requiring the administration of a panel of at least four antimicrobial drugs for the duration of six months.
Fizza Mushtaq, Syed Mohsin Raza, Adeel Ahmad, Hina Aslam, Atiqa Adeel, Sidrah Saleem, Irfan Ahmad   +6 more
doaj   +1 more source

Resistance to first- and second-line antituberculosis drugs in Southern Taiwan: Implications for empirical treatment

Journal of Microbiology, Immunology and Infection, 2018
Background: Multidrug-resistant and extensively drug-resistant tuberculosis infections cause public health concerns worldwide. Local epidemiologic data about the drug resistance of Mycobacterium tuberculosis isolate (Mtb) is critical to guide appropriate
Cheng-Yu Kuo, Wen-Hung Wang, Chung-Hao Huang, Yen-Hsu Chen, Po-Liang Lu   +4 more
doaj   +1 more source