Results 11 to 20 of about 12,743 (165)

Colorimetric methods for rapid determination of pyrazinamide resistance

International Journal of Mycobacteriology, 2020
Background: Because pyrazinamide (PZA) is only effective for Mycobacterium tuberculosis at an acidic pH, susceptibility tests are more difficult to perform than those for other anti-tuberculosis (TB) drugs.
Ahmet Ugur Akbal, Belma Durupinar, Ahmet Yilmaz Coban   +2 more
doaj   +3 more sources

Improved Bactec MGIT 960 Pyrazinamide Test Decreases Detection of False Mycobacterium tuberculosis Pyrazinamide Resistance [PDF]

Journal of Clinical Microbiology, 2017
Pyrazinamide (PZA) is a key drug for the treatment of tuberculosis (TB). Resistance to PZA is caused mostly by mutations in the pncA gene, encoding pyrazinamidase, which converts the prodrug PZA to the active form, pyrazinoic acid ([1][1], [2][2]).
Alessandro Mustazzolu, , Angelo Iacobino   +2 more
exaly   +5 more sources

A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide

Nature Communications, 2017
The antibiotic pyrazinamide is central to tuberculosis treatment regimens, globally. Despite its efficacy, resistance to the drug is increasing. Here, Eric Rubin and colleagues characterise the genetic basis of pyrazinamide resistance.
Adam N. Yadon, Kashmeel Maharaj, John H. Adamson, Yi-Pin Lai, James C. Sacchettini, Thomas R. Ioerger, Eric J. Rubin, Alexander S. Pym   +7 more
doaj   +5 more sources

Pyrazinamide Resistance and pncA Mutation Profiles in Multidrug Resistant Mycobacterium Tuberculosis. [PDF]

Infect Drug Resist, 2022
Pyrazinamide (PZA) is a critical component of standardized chemotherapy for tuberculosis (TB) and is recommended for the treatment of multidrug-resistant (MDR) TB. We aimed to characterize mutations in pncA of M. tuberculosis and evaluate their diagnostic accuracy for PZA susceptibility in China.
Shi D, Zhou Q, Xu S, Zhu Y, Li H, Xu Y.
europepmc   +5 more sources

First-line drug-resistant tuberculosis among children under 15 years in Ethiopia: insights from phenotypic and whole-genome sequencing approaches [PDF]

BMC Infectious Diseases
Background Childhood drug-resistant tuberculosis is often underdiagnosed and inadequately characterized due to the paucibacillary nature of the disease.
Yeshiwork Abebaw, Abaysew Ayele, Arash Ghodousi, Dawit Hailu Alemayehu, Gebremedhin Gebremicael, Getu Diriba, Getachew Seid, Andrea Maurizio Cabibbe, Markos Abebe, Anandi Sheth, Rahel Argaw, Woldaregay Erku Abegaz   +11 more
doaj   +2 more sources

Structure guided prediction of Pyrazinamide resistance mutations in pncA. [PDF]

Sci Rep, 2020
AbstractPyrazinamide plays an important role in tuberculosis treatment; however, its use is complicated by side-effects and challenges with reliable drug susceptibility testing. Resistance to pyrazinamide is largely driven by mutations in pyrazinamidase (pncA), responsible for drug activation, but genetic heterogeneity has hindered development of a ...
Karmakar M, Rodrigues CHM, Horan K, Denholm JT, Ascher DB.   +4 more
europepmc   +7 more sources

Pyrazinamide resistance in Swedish multidrug-resistant tuberculosis 2003–2013

International Journal of Mycobacteriology, 2015
Aims and objectives: The aim of this study is to determine the prevalence of pyrazinamide (PZA) resistance among multidrug-resistant Mycobacterium tuberculosis (MDR-TB) strains isolated in Sweden between 2003 and 2013 and to study the correlation between
M Mansjö, J Werngren, S Hoffner
doaj   +2 more sources

Mechanisms of Pyrazinamide Action and Resistance [PDF]

Microbiology Spectrum, 2014
ABSTRACT Pyrazinamide (PZA) is a unique antituberculosis (anti-TB) drug that plays a key role in shortening TB therapy. PZA kills nonreplicating persisters that other TB drugs fail to kill, which makes it an essential drug for inclusion in any drug combinations for treating drug-susceptible and drug-resistant TB such as multidrug-
Ying, Zhang, Wanliang, Shi, Wenhong, Zhang, Denis, Mitchison   +3 more
openaire   +3 more sources

Pyrazinamide resistance of novel mutations in pncA and their dynamic behavior. [PDF]

RSC Adv, 2020
We performed several analyses to unveil the pyrazinamide-resistance mechanism of R123P, T76P, G150A, and H71R mutants through molecular dynamics simulations.
Ali A, Khan MT, Khan A, Ali S, Chinnasamy S, Akhtar K, Shafiq A, Wei DQ.   +7 more
europepmc   +4 more sources

Mutations and insights into the molecular mechanisms of resistance of Mycobacterium tuberculosis to first-line [PDF]

Genetics and Molecular Biology, 2023
Genetically antimicrobial resistance in Mycobacterium tuberculosis is currently one of the most important aspects of tuberculosis, considering that there are emerging resistant strains for almost every known drug used for its treatment.
Nicolas de Oliveira Rossini, Marcio Vinicius Bertacine Dias   +1 more
doaj   +1 more source