Results 11 to 20 of about 14,172 (227)

A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide [PDF]

Nature Communications, 2017
The antibiotic pyrazinamide is central to tuberculosis treatment regimens, globally. Despite its efficacy, resistance to the drug is increasing. Here, Eric Rubin and colleagues characterise the genetic basis of pyrazinamide resistance.
Adam N. Yadon, Kashmeel Maharaj, John H. Adamson, Yi-Pin Lai, James C. Sacchettini, Thomas R. Ioerger, Eric J. Rubin, Alexander S. Pym   +7 more
doaj   +8 more sources

Structure guided prediction of Pyrazinamide resistance mutations in pncA. [PDF]

Sci Rep, 2020
AbstractPyrazinamide plays an important role in tuberculosis treatment; however, its use is complicated by side-effects and challenges with reliable drug susceptibility testing. Resistance to pyrazinamide is largely driven by mutations in pyrazinamidase (pncA), responsible for drug activation, but genetic heterogeneity has hindered development of a ...
Karmakar M, Rodrigues CHM, Horan K, Denholm JT, Ascher DB.   +4 more
europepmc   +13 more sources

Pyrazinamide resistance in multidrug-resistant Mycobacterium tuberculosis isolates in Japan [PDF]

Clinical Microbiology and Infection, 2010
Thirty-six multidrug-resistant (MDR) Mycobacterium tuberculosis isolates collected in Japan were examined for pyrazinamide susceptibility and pyrazinamidase activity, and analysed by pncA sequencing and a hybridization-based line probe assay (LiPA), which was used to detect pncA mutations for the rapid identification of pyrazinamide-resistant isolates.
Ando, H., Mitarai, S., Kondo, Y., Suetake, T., Sekiguchi, J.-I., Kato, S., Mori, T., Kirikae, T.   +7 more
openaire   +4 more sources

Improved Bactec MGIT 960 Pyrazinamide Test Decreases Detection of False Mycobacterium tuberculosis Pyrazinamide Resistance. [PDF]

J Clin Microbiol, 2017
Pyrazinamide (PZA) is a key drug for the treatment of tuberculosis (TB). Resistance to PZA is caused mostly by mutations in the pncA gene, encoding pyrazinamidase, which converts the prodrug PZA to the active form, pyrazinoic acid ([1][1], [2][2]).
Mustazzolu A, Iacobino A, Giannoni F, Piersimoni C, Italian Multicentre Study on Resistance to Antituberculosis Drugs (SMIRA) Group, Fattorini L.   +5 more
europepmc   +5 more sources

Value of pyrazinamide for composition of new treatment regimens for multidrug-resistant Mycobacterium tuberculosis in China [PDF]

BMC Infectious Diseases, 2020
Background Pyrazinamide still may be a useful drug for treatment of rifampin-resistant (RR-TB) or multidrug-resistant tuberculosis (MDR-TB) in China while awaiting scale up of new drugs and regimens including bedaquiline and linezolid.
Hui Xia, Susan van den Hof, Frank Cobelens, Yang Zhou, Bing Zhao, Shengfen Wang, Yanlin Zhao   +6 more
doaj   +2 more sources

Colorimetric methods for rapid determination of pyrazinamide resistance

International Journal of Mycobacteriology, 2020
Background: Because pyrazinamide (PZA) is only effective for Mycobacterium tuberculosis at an acidic pH, susceptibility tests are more difficult to perform than those for other anti-tuberculosis (TB) drugs.
Ahmet Ugur Akbal, Belma Durupinar, Ahmet Yilmaz Coban   +2 more
doaj   +3 more sources

A multiple genome analysis of Mycobacterium tuberculosis reveals specific novel genes and mutations associated with pyrazinamide resistance [PDF]

BMC Genomics, 2017
Background Tuberculosis (TB) is a major global health problem and drug resistance compromises the efforts to control this disease. Pyrazinamide (PZA) is an important drug used in both first and second line treatment regimes.
Patricia Sheen, David Requena, Eduardo Gushiken, Robert H. Gilman, Ricardo Antiparra, Bryan Lucero, Pilar Lizárraga, Basilio Cieza, Elisa Roncal, Louis Grandjean, Arnab Pain, Ruth McNerney, Taane G. Clark, David Moore, Mirko Zimic   +14 more
doaj   +2 more sources

Correction: Immunological detection of pyrazine-2-carboxylic acid for the detection of pyrazinamide resistance in Mycobacterium tuberculosis. [PDF]

PLoS One, 2021
Florentini EA, Angulo N, Gilman RH, Alcántara R, Roncal E, Antiparra R, Toscano E, Vallejos K, Kirwan DE, Zimic M, Sheen P.   +10 more
europepmc   +3 more sources

Toward precision detection of pyrazinamide resistance: critical concentration assessment and rapid molecular method validation [PDF]

Front Microbiol
Zhao Y, Tian L, Wang N, Chen H, Chen S, Yu L, Pang M, Ding B, Li J, Li C, Dai X.   +10 more
europepmc   +3 more sources

Isoniazid resistance profile and associated levofloxacin and pyrazinamide resistance in rifampicin resistant and sensitive isolates/from pulmonary and extrapulmonary tuberculosis patients in Pakistan: A laboratory based surveillance study 2015-19. [PDF]

PLoS ONE, 2020
BackgroundPakistan is among top five high burden countries for tuberculosis and drug resistant TB. Among rifampicin sensitive new pulmonary TB (PTB), prevalence of isoniazid resistance is 8.3% (95%CI: 7.0-10.7) and resistance to fluoroquinolone is higher
Sabira Tahseen, Faisal Masood Khanzada, Alamdar Hussain Rizvi, Mahmood Qadir, Aisha Ghazal, Aurangzaib Quadir Baloch, Tehmina Mustafa   +6 more
doaj   +2 more sources