Next-generation sequencing to characterise pyrazinamide resistance in Mycobacterium tuberculosis isolates from two Balkan countries [PDF]
Journal of Global Antimicrobial Resistance, 2022 : Objectives: Next-generation sequencing (NGS) can provide a comprehensive analysis of the genetic alterations most commonly linked with pyrazinamide (PZA) resistance. However, there are no studies reporting the molecular background of PZA resistance in
Eva Sodja +4 more
doaj +3 more sources
Atypical Genetic Basis of Pyrazinamide Resistance in Monoresistant Mycobacterium tuberculosis [PDF]
Antimicrobial Agents and Chemotherapy, 2021 Samuel J Modlin +2 more
exaly +2 more sources
Detection of Mycobacterium Tuberculosis Resistance to Pyrazinamide Antibiotic Using Polymerase Chain Reaction (PCR) Technique [PDF]
, 2022 The tuberculosis treatment control program is constrained by the outbreak of TB that is resistant to anti-tuberculosis drugs (OAT), especially multidrug-resistant tuberculosis.
Edy Kurniawan, Idham Halid
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Pyrazinamide resistance in Mycobacterium tuberculosis arises after rifampicin and fluoroquinolone resistance. [PDF]
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2015 Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (TB) constitute a major public health concern.To determine the timing of pncA mutations that confer pyrazinamide (PZA) resistance in relation to mutations conferring resistance to isoniazid (INH) and rifampicin (RMP).Isolates from two major urban ...
A. K. Alame-Emane +9 more
openaire +4 more sources
High prevalence of phenotypic pyrazinamide resistance and its association with pncA gene mutations in Mycobacterium tuberculosis isolates from Uganda. [PDF]
PLoS One, 2020 Naluyange R +5 more
europepmc +3 more sources
First-line drug-resistant tuberculosis among children under 15 years in Ethiopia: insights from phenotypic and whole-genome sequencing approaches [PDF]
BMC Infectious DiseasesBackground Childhood drug-resistant tuberculosis is often underdiagnosed and inadequately characterized due to the paucibacillary nature of the disease.
Yeshiwork Abebaw +11 more
doaj +2 more sources
Pyrazinamide Resistance and pncA Mutation Profiles in Multidrug Resistant Mycobacterium Tuberculosis. [PDF]
Infect Drug Resist, 2022 Pyrazinamide (PZA) is a critical component of standardized chemotherapy for tuberculosis (TB) and is recommended for the treatment of multidrug-resistant (MDR) TB. We aimed to characterize mutations in pncA of M. tuberculosis and evaluate their diagnostic accuracy for PZA susceptibility in China.
Shi D, Zhou Q, Xu S, Zhu Y, Li H, Xu Y.
europepmc +5 more sources
Comparative Performance of Genomic Methods for the Detection of Pyrazinamide Resistance and Heteroresistance in Mycobacterium tuberculosis. [PDF]
J Clin Microbiol, 2022 : Pyrazinamide is an important component of both drug-susceptible and drug-resistant tuberculosis treatment regimens. Although approximately 50% of rifampin-resistant isolates are also resistant to pyrazinamide, pyrazinamide susceptibility testing is not
Whitfield MG +8 more
europepmc +3 more sources
Phenotypic and molecular characterization of pyrazinamide resistance among multidrug-resistant Mycobacterium tuberculosis isolates in Ningbo, China. [PDF]
BMC Infect Dis, 2021 Che Y, Bo D, Lin X, Chen T, He T, Lin Y.
europepmc +3 more sources
Pyrazinoic acid efflux rate in Mycobacterium tuberculosis is a better proxy of pyrazinamide resistance [PDF]
, 2011 Pyrazinamide is one of the most important drugs in the treatment of latent Mycobacterium tuberculosis infection. The emergence of strains resistant to pyrazinamide represents an important public health problem, as both first- and second-line treatment ...
Mirko Zimic +5 more
openalex +3 more sources