Results 21 to 30 of about 2,204,307 (197)
Mechanisms of Pyrazinamide Action and Resistance [PDF]
Microbiology Spectrum, 2014 ABSTRACT Pyrazinamide (PZA) is a unique antituberculosis (anti-TB) drug that plays a key role in shortening TB therapy. PZA kills nonreplicating persisters that other TB drugs fail to kill, which makes it an essential drug for inclusion in any drug combinations for treating drug-susceptible and drug-resistant TB such as multidrug-
Ying, Zhang +3 more
openaire +3 more sources
Mutations and insights into the molecular mechanisms of resistance of Mycobacterium tuberculosis to first-line [PDF]
Genetics and Molecular Biology, 2023 Genetically antimicrobial resistance in Mycobacterium tuberculosis is currently one of the most important aspects of tuberculosis, considering that there are emerging resistant strains for almost every known drug used for its treatment.
Nicolas de Oliveira Rossini +1 more
doaj +1 more source
Pyrazinamide resistance in Swedish multidrug-resistant tuberculosis 2003–2013
International Journal of Mycobacteriology, 2015 Aims and objectives: The aim of this study is to determine the prevalence of pyrazinamide (PZA) resistance among multidrug-resistant Mycobacterium tuberculosis (MDR-TB) strains isolated in Sweden between 2003 and 2013 and to study the correlation between
M Mansjö, J Werngren, S Hoffner
doaj +2 more sources
Pyrazinamide resistance of novel mutations in pncA and their dynamic behavior. [PDF]
RSC Adv, 2020 We performed several analyses to unveil the pyrazinamide-resistance mechanism of R123P, T76P, G150A, and H71R mutants through molecular dynamics simulations.
Ali A +7 more
europepmc +4 more sources
PLoS ONE, 2022 BackgroundEthiopia is one of the high multidrug-resistant tuberculosis (MDR-TB) burden countries. However, phenotypic drug susceptibility testing can take several weeks due to the slow growth of Mycobacterium tuberculosis complex (MTBC) strains.
Eyob Abera Mesfin +7 more
doaj +1 more source
Frontiers in Microbiology, 2021 Pyrazinamide (PZA) is widely used to treat drug-sensitive or multidrug resistance tuberculosis. However, conventional PZA susceptibility tests of clinical isolates are rather difficult because of the requirement of acid pH.
Kun Li +6 more
doaj +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Туберкулез и болезни лёгких, 2020 The objective of the study: to assess the prevalence of drug resistance of tuberculous mycobacteria (MTB) to pyrazinamide, linezolid, cross-resistance to fluoroquinolones, and cross-resistance to injectable anti-tuberculosis drugs among tuberculosis ...
P. N. Golubchikov +5 more
doaj +1 more source
Counting Pyrazinamide in Regimens for Multidrug-Resistant Tuberculosis [PDF]
Annals of the American Thoracic Society, 2015 Abstract Rationale For treatment of multidrug-resistant tuberculosis, World Health Organization (WHO) guidelines recommend four likely effective drugs plus pyrazinamide (PZA), irrespective of the likely effectiveness of PZA in an individual patient.
Molly F, Franke +7 more
openaire +2 more sources
Impact of pyrazinamide resistance on multidrug-resistant tuberculosis in Karakalpakstan, Uzbekistan [PDF]
The International Journal of Tuberculosis and Lung Disease, 2018 The World Health Organization (WHO) recommends the inclusion of pyrazinamide (PZA) in treatment regimens for multidrug-resistant tuberculosis (MDR-TB) unless resistance has been confirmed.To investigate the association between PZA susceptibility and MDR-TB treatment outcome among patients treated with a PZA-containing regimen and whether the duration ...
Kuhlin, J +10 more
openaire +2 more sources