Results 61 to 70 of about 12,743 (165)

Next-generation sequencing to characterise pyrazinamide resistance in Mycobacterium tuberculosis isolates from two Balkan countries

Journal of Global Antimicrobial Resistance, 2022
: Objectives: Next-generation sequencing (NGS) can provide a comprehensive analysis of the genetic alterations most commonly linked with pyrazinamide (PZA) resistance. However, there are no studies reporting the molecular background of PZA resistance in
Eva Sodja, Simon Koren, Nataša Toplak, Sara Truden, Manca Žolnir-Dovč   +4 more
doaj   +1 more source

A Rare Case of Scrofuloderma Presenting as Recurrent Tuberculosis in a Young Patient

Respirology Case Reports, Volume 14, Issue 7, July 2026.
We report a rare case of scrofuloderma presenting as recurrent tuberculosis in a young patient with a persistent skin ulcer on the chest wall. In addition to bacteriological and histopathological evaluation of the skin lesions, a detailed examination of extracutaneous lesions is essential for an accurate diagnosis and the most suitable treatment ...
Yoshihiro Okada, Asuka Okada, Shin Miyagawa, Ami Arimoto, Taisei Furumuro, Masanori Izuka, Yuma Watabe, Izumi Sato, Yusuke Inui, Masahide Ueda, Takahiro Ibaraki, Hideaki Takenaka, Sumito Choh   +12 more
wiley   +1 more source

The paradox of pyrazinamide: an update on the molecular mechanisms of pyrazinamide resistance in Mycobacteria.

The Journal of communicable diseases, 2007
Pyrazinamide (PZA) is an important front line anti-tuberculosis drug because of its sterilizing activity against semi-dormant tubercle bacilli. In spite of its remarkable role in shortening the treatment duration from 9 months to 6 months when used in combination with Rifampicin and Isoniazid, PZA remains a difficult paradox because of its incompletely
Pushpendra, Singh, A K, Mishra, S K, Malonia, D S, Chauhan, V D, Sharma, K, Venkatesan, V M, Katoch   +6 more
openaire   +1 more source

Clinical guideline highlights for the hospitalist: Updates on the treatment of drug‐susceptible and drug‐resistant tuberculosis

Journal of Hospital Medicine, EarlyView.
Allison Stickles, Anna Poston‐Blahnik, Elizabeth Schlaudecker, Moises Huaman   +3 more
wiley   +1 more source

Contezolid in the Treatment of Multidrug‐Resistant Tuberculous Meningitis: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Multidrug‐resistant tuberculous meningitis (MDR‐TBM) has a high mortality rate, and treatment options are limited. Linezolid is recommended for refractory cases but often causes intolerable adverse reactions such as peripheral neuropathy. Contezolid, a novel oxazolidinone, has shown better safety profiles in preclinical and early clinical ...
Na Wang, Xingyu Li, Qiaoyi Yan, Haitao Su, Yufeng Liu, Yanhong Li, Chunrong Yang, Yingchun Gu, Taoli Yan, Qiuzhen Wang, Xia Liu   +10 more
wiley   +1 more source

Pyrazinamide resistance in Mycobacterium tuberculosis fails to bite? [PDF]

Pathogens and Disease, 2015
In contrast to most other antimycobacterial drugs where--particularly in multidrug-resistant (MDR) strains--a limited number of resistance mutations dominate, pyrazinamide (PZA) resistance associated mutations remain highly diverse with limited clustering.
Alice L, den Hertog, Sarah, Sengstake, Richard M, Anthony   +2 more
openaire   +2 more sources

High isoniazid resistance rates in rifampicin susceptible Mycobacterium tuberculosis pulmonary isolates from Pakistan.

PLoS ONE, 2012
BackgroundRapid new diagnostic methods (including Xpert MTB/RIF assay) use rifampicin resistance as a surrogate marker for multidrug resistant tuberculosis. Patients infected with rifampicin susceptible strains are prescribed first line anti-tuberculosis
Naima Fasih, Yasraba Rafiq, Kausar Jabeen, Rumina Hasan   +3 more
doaj   +1 more source

Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa. [PDF]

PLoS ONE, 2009
The KZN strain family of Mycobacterium tuberculosis is a highly virulent strain endemic to the KwaZulu-Natal region of South Africa, which has recently experienced an outbreak of extensively-drug resistant tuberculosis.
Thomas R Ioerger, Sunwoo Koo, Eun-Gyu No, Xiaohua Chen, Michelle H Larsen, William R Jacobs, Manormoney Pillay, A Willem Sturm, James C Sacchettini   +8 more
doaj   +1 more source

The Role of Pharmacovigilance Database in Identifying Antibiotic Resistance and Inappropriate Use: An Analysis of VigiBase Reports From Lower‐Middle‐Income Countries

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 6, June 2026.
ABSTRACT Background Digital databases such as pharmacovigilance (PV) databases could provide unique opportunities to monitor trends in suspected antibiotic resistance, ineffectiveness, and misuse, extending beyond their traditional role of tracking adverse drug reactions (ADRs).
Hager Saleh, Joseph Mitchell, Cecilia Stålsby Lundborg, Megha Sharma   +3 more
wiley   +1 more source

Thiazolidinedione–Pyrazolopyrimidinone Molecular Hybrids With Alkyl Spacers: Potential Antitubercular Agents Complemented by Molecular Modeling

ChemistrySelect, Volume 11, Issue 24, 25 June 2026.
We report the synthesis of 21 novel thiazolidinedione–pyrazolopyrimidinone derivatives (12a–u), prepared by coupling thiazolidinedione and pyrazolopyrimidinone pharmacophores through various alkyl linkers. The compounds were characterized spectroscopically and evaluated against the Mtb H37Rv strain, identifying compounds 5c and 5d as potent ...
Pule Seboletswe, Gobind Kumar, Nontobeko Gcabashe, Sanjeev Dhawan, Neha Manhas, Ankit, Audrey Jordaan, Digby F. Warner, Parvesh Singh   +8 more
wiley   +1 more source