Results 61 to 70 of about 2,204,307 (197)

Novel Pyrazole‐4‐Carbaldehyde Derivatives Having Potent COX‐2 Inhibition and Anti‐Tubercular Activity: Microwave‐Assisted Green Synthesis and Molecular Docking

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
ABSTRACT A series of 1‐(4‐Chorophenyl)‐3Aryl‐1‐H‐pyrazole‐4‐carbaldehyde derivatives were synthesized under the microwave irradiation (MW) technique. IR, 1H‐NMR, 13C‐NMR, and mass spectroscopic techniques were used to confirm the structure of the synthesized compounds.
Megha Kokane, Dnyandev Bhosale, Dattatraya Raut, Pushpa Hadimani, Ashwini Narale, Prafulla Choudhari, Anjana Lawand   +6 more
wiley   +1 more source

A Multi‐Scale Computational Framework for Anti‐Persister Tuberculosis Drug Discovery

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
This review presents an integrated QSAR–scaffold design–docking–MD framework for discovering anti‐persister tuberculosis agents active in dormant granuloma‐like conditions. By targeting Mtb bioenergetics and prioritising dual NDH‐2/cytochrome bd oxidase inhibition, the workflow advances rational design of candidates with higher resistance barriers ...
Said Moshawih, Anguraj Moulishankar, Chee Yan Choo, Khang Wen Goh, Chrismawan Ardianto, Azam Che Idris, Long Chiau Ming   +6 more
wiley   +1 more source

Initial resistance to companion drugs should not be considered an exclusion criterion for the shorter multidrug-resistant tuberculosis treatment regimen

International Journal of Infectious Diseases, 2020
Objectives: We investigated whether companion drug resistance was associated with adverse outcomes of the shorter multidrug-resistant tuberculosis (MDR-TB) treatment regimen in Bangladesh after adjustment for fluoroquinolone resistance.
Pauline Lempens, Tom Decroo, Kya J.M. Aung, Mohammad A. Hossain, Leen Rigouts, Conor J. Meehan, Armand Van Deun, Bouke C. de Jong   +7 more
doaj   +1 more source

Diagnosis and Management of Infectious Encephalitis in Adults: Guidelines From the European Academy of Neurology and European Society of Clinical Microbiology and Infectious Diseases

European Journal of Neurology, Volume 33, Issue 10, October 2026.
ABSTRACT Background Encephalitis is difficult to diagnose and manage, posing a challenge to clinicians. Since the last European guidelines were published in 2010, novel causes have emerged, diagnostic processes have evolved and treatments assessed which need to be reflected in updated guidelines.
Julia Granerod, Johann Sellner, Jean‐Paul Stahl, Sylviane Defres, Alexandra Mailles, Erich Schmutzhard, Elisabeth Aurelius, Thomas Whitfield, Luca Massacesi, Maarten J. Titulaer, Pille Taba, Benedict D. Michael, Tehmina Bharucha, Lance Turtle, Brendan Sargent, Arina Tamborska, Jonathan Cattrall, Yun Huang, Eva Maria Hodel, Suzannah Lant, Glynn Webb, Rajish S. K. Shil, Shalley Dhar, Diederik van de Beek, Marie Studahl, Matthijs C. Brouwer, Uta Meyding‐Lamade, Ava Easton, Bhagteshwar Singh, Tom Solomon   +29 more
wiley   +1 more source

Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data.

PLoS Medicine, 2020
BackgroundThe surveillance of drug resistance among tuberculosis (TB) patients is central to combatting the global TB epidemic and preventing the spread of antimicrobial resistance. Isoniazid and rifampicin are two of the most powerful first-line anti-TB
Anna S Dean, Matteo Zignol, Andrea Maurizio Cabibbe, Dennis Falzon, Philippe Glaziou, Daniela Maria Cirillo, Claudio U Köser, Lice Y Gonzalez-Angulo, Olga Tosas-Auget, Nazir Ismail, Sabira Tahseen, Maria Cecilia G Ama, Alena Skrahina, Natavan Alikhanova, S M Mostofa Kamal, Katherine Floyd   +15 more
doaj   +1 more source

Tuberculosis Misdiagnosed as Bronchogenic Carcinoma: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT The patient, a 77‐year‐old male smoker, presented to the Emergency Department with dyspnea, cough, fever, night sweats, and 12 kg weight loss, initially suggesting COPD or lung cancer. Chest CT revealed a right upper lobe mass, pleural effusion, and lymphadenopathy, prompting suspicion of malignancy.
Pejman Hosseinzadeh, Sara Samadi, Shirin Taraz Jamshidi, Sayed Mortaza Fayez, Mahnaz Mozdourian   +4 more
wiley   +1 more source

Bifidobacterium adolescentis is resistant to pyrazinamide, isoniazid, and streptomycin

Scientific Reports
The current study aims to understand the resistance of Bifidobacterium adolescentis to different anti-tubercular drugs (first-line oral tuberculosis drugs). The bacteria were grown with anti-tubercular drugs such as isoniazid, pyrazinamide, and streptomycin to better understand the resistance phenomena.
Anagha Nellikka, Athira Cheruvari, Prasanna Vasu, Sarma Mutturi, Kammara Rajagopal   +4 more
openaire   +3 more sources

The molecular basis of resistance to isoniazid, rifampin, and pyrazinamide in Mycobacterium tuberculosis [PDF]

Respiratory Research, 2001
Multidrug-resistant (MDR) strains of Mycobacterium tuberculosis have emerged worldwide. In many countries and regions, these resistant strains constitute a serious threat to the efficacy of tuberculosis control programs. An important element in gaining control of this epidemic is developing an understanding of the molecular basis of resistance to the ...
Parsons Linda M, Somoskovi Akos, Salfinger Max   +2 more
openaire   +3 more sources

Population-based resistance of Mycobacterium tuberculosis isolates to pyrazinamide and fluoroquinolones : results from a multicountry surveillance project [PDF]

, 2016
BACKGROUND : Pyrazinamide and fluoroquinolones are essential antituberculosis drugs in new rifampicin-sparing regimens. However, little information about the extent of resistance to these drugs at the population level is available.
Tahseen, Sabira, Ismail, Nazir Ahmed, Kimerling, Michael, Alikhanova, Natavan, Skrahina, Alena, Seyfaddinova, Mehriban, Omar, Shaheed V., Ruesch-Gerdes, Sabine, Ismail, Nazir, Dadu, Andrei, Andres, Sonke, Kamal, Mostofa, Gilpin, Christopher, Dreyer, Andries, Husain, Ashaque, Hasan, Rumina, Rigouts, Leen, Wells, William A., Cirillo, Daniela Maria, Weyer, Karin, Omar, Shaheed V, Hasan, Zahra, Wells, William A, Mansjo, Mikael, Raviglione, Mario C., Omar, Shaheed Vally, Hoffner, Sven, Qadeer, Ejaz, Raviglione, Mario C, Driesen, Michèle, Niemann, Stefan, Cabibbe, Andrea Maurizio, Schito, Marco, Dean, Anna S, Floyd, Katherine, Hussain, Alamdar, Zignol, Matteo, Mukadi, Ya Diul, Mvusi, Lindiwe, Dean, Anna S., Rumina, Rumina, Gerdes, Sabine Ruesch   +41 more
core   +1 more source

Pyrazinamide Resistance among Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates in Myanmar. [PDF]

Antimicrob Agents Chemother, 2018
Aung WW, Ei PW, Nyunt WW, Htwe MM, Win SM, Aye KT, Mon AS, Aung ST, Chang CL, Lee JS.   +9 more
europepmc   +4 more sources