Results 61 to 70 of about 14,172 (227)

Nitrate reductase assay for the rapid detection of pyrazinamide resistance in Mycobacterium tuberculosis using nicotinamide [PDF]

, 2008
OBJECTIVES: The purpose of this study was to develop the nitrate reductase assay (NRA) for the rapid detection of pyrazinamide resistance in Mycobacterium tuberculosis using nicotinamide resistance as a marker of pyrazinamide resistance in Löwenstein ...
Palomino, J. C., Palomino, Juan Carlos, Cubillos-Ruiz, A., Del Portillo, Patricia, Martin, Anandi, Von Groll, Andrea, Del Portillo, P., Portaels, Françoise, Groll, Andrea Von, Martin, A., Portillo, Patricia Del, Portaels, F., Cubillos-Ruiz, Andres, Von Groll, A.   +13 more
core   +1 more source

Prevalence and transmission of pyrazinamide resistant Mycobacterium tuberculosis in China [PDF]

Tuberculosis, 2016
Pyrazinamide (PZA) is an important first-line anti-tuberculosis drug, however, there are relatively few available data on PZA resistant (PZA-R) rate in China. From June 2009 to June 2012, we selected 493 isolates from five field settings in China to investigate PZA-R by pncA gene sequencing.
Peng, Xu, Jie, Wu, Chongguang, Yang, Tao, Luo, Xin, Shen, Yangyi, Zhang, Chijioke A, Nsofor, Guofeng, Zhu, Brigitte, Gicquel, Qian, Gao   +9 more
openaire   +2 more sources

SNPs leading to rifampicin, isoniazid and pyrazinamide resistance in XDR strains. [PDF]

, 2015
All strain were resistant to rifampicin (RIF, 1 μg/ml), isoniazid (INH, 1 μg/ml) and pyrazinamide (PZA, 100μg/ml). ‘#’ mutations in the rifampicin- resistance determining region (RRDR), the number in parenthesis indicates the number of MTB isolates from ...
Mridul Nair (590036), Asho Ali (73920), Kim Mallard (362508), Taane G. Clark (106263), Rumina Hasan (73926), Zahra Hasan (73921), Ruth McNerney (227467), Francesc Coll (495630), Arnab Pain (37809), Grant Hill-Cawthorne (696209)   +9 more
core   +1 more source

Exploring of pyrazinamidase recombinant activity from PZA-sensitive and resistant Mycobacterium tuberculosis expressed in Escherichia coli BL21 (DE3) [PDF]

Brazilian Journal of Biology
The mutations of pncA gene encoding pyrazinamidase/PZase in Mycobacterium tuberculosis are often associated with pyrazinamide/PZA resistance. The H and R1 isolates showed significant phenotypic differences to PZA.
P. Purkan, S. Hadi, W. Retnowati, S. Sumarsih, D. K. Wahyuni, B. Piluharto, T. M. Panjaitan, C. Ifada, A. Nadila, B. A. Nabilah   +9 more
doaj   +1 more source

Refining MDR-TB treatment regimens for ultra short therapy (TB-TRUST): study protocol for a randomized controlled trial

BMC Infectious Diseases, 2021
Background Multidrug-resistant tuberculosis (MDR-TB) are unsatisfied to treat, pressing more effective and innovative treatment regimens. New efficient regimens for MDR-TB have obtained high treatment success rates.
Taoping Weng, Feng Sun, Yang Li, Jiazhen Chen, Xinchang Chen, Rong Li, Shijia Ge, Yanlin Zhao, Wenhong Zhang   +8 more
doaj   +1 more source

Insight to pyrazinamide resistance in Mycobacterium tuberculosis by molecular docking [PDF]

Bioinformation, 2009
Pyrazinamide (PZA) - an important drug in the anti-tuberculosis therapy, activated by an enzyme Pyrazinamidase (PZase). The basis of PZA resistance in Mycobacterium tuberculosis was owing to mutation in pncA gene coding for PZase. Homology modeling of PZase was performed using software Discovery Studio (DS) 2.0 based on the crystal structure of the ...
Unissa, A N, Selvakumar, N, Hassan, S
openaire   +3 more sources

Pyrazinoic Acid Inhibits the Bifunctional Enzyme (Rv2783) in Mycobacterium tuberculosis by Competing with tmRNA

Pathogens, 2019
Pyrazinamide (PZA) is a key drug for tuberculosis treatment. The active form of PZA, pyrazinoic acid (POA), appears to inhibit multiple targets in M. tuberculosis. Recently, the bifunctional enzyme Rv2783 was reported as a new target of POA. However, the
Lei He, Peng Cui, Wanliang Shi, Qiong Li, Wenhong Zhang, Min Li, Ying Zhang   +6 more
doaj   +1 more source

Role of rpsA Gene Sequencing in Diagnosis of Pyrazinamide Resistance [PDF]

Journal of Clinical Microbiology, 2013
We read with great interest the article by Alexander and colleagues ([1][1]) on the frequency of rpsA mutations in pyrazinamide-susceptible and resistant isolates with a wild-type pncA gene. In contrast to the report of Shi and colleagues ([2][2]), Alexander and colleagues could not find any ...
Simons, SO, Mulder, A, van Ingen, J, Boeree, MJ, van Soolingen, D   +4 more
openaire   +5 more sources

Mutations conferring resistance to first-line anti-tuberculosis drugs in Peru: a systematic review of the literature

Revista Peruana de Medicina Experimental y Salud Pública, 2019
Objective. To systematize available information regarding mutations that confer resistance to first-line anti-tuberculosis drugs. Materials and Methods.
Aiko Vigo, Lely Solari, David Santos, Zully M. Puyén   +3 more
doaj   +1 more source

Preserved Spermatogenesis and Hormonal Function in Men Receiving a Pretomanid Regimen (BPaMZ) for Pulmonary Drug‐Resistant Tuberculosis

Clinical Pharmacology &Therapeutics, EarlyView.
Pretomanid is a component of the World Health Organization‐recommended treatment regimen for drug‐resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no corresponding effects were observed in nonhuman primates nor clinical hormone ...
Pauline Howell, Antonio Lombardi, William Brumskine, Lali Mikiashvili, Kim Boekelheide, Joanna Moreira, Alda Holsta, Matthew Betteridge, Lindsay Thompson, Angela Crook, Paul Bruinenberg, Maria Beumont, Eugene Sun, Francesca Conradie   +13 more
wiley   +1 more source