Results 81 to 90 of about 2,204,307 (197)

Hypercalcemia in a Patient With Spinal Tuberculosis and Aspergillus Co‐Infection: A Case‐Report

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Background Tuberculosis (TB), one of the leading infectious causes of mortality worldwide, may disseminate hematogenously and result in extrapulmonary manifestations. Spinal tuberculosis (ST) is an uncommon but serious form of extrapulmonary TB.
Negin Parsa, Amirpasha Amlelshahbaz, Hamidreza Soltani   +2 more
wiley   +1 more source

The paradox of pyrazinamide: an update on the molecular mechanisms of pyrazinamide resistance in Mycobacteria.

The Journal of communicable diseases, 2007
Pyrazinamide (PZA) is an important front line anti-tuberculosis drug because of its sterilizing activity against semi-dormant tubercle bacilli. In spite of its remarkable role in shortening the treatment duration from 9 months to 6 months when used in combination with Rifampicin and Isoniazid, PZA remains a difficult paradox because of its incompletely
Pushpendra, Singh, A K, Mishra, S K, Malonia, D S, Chauhan, V D, Sharma, K, Venkatesan, V M, Katoch   +6 more
openaire   +1 more source

Genetic Variants at the NAT2 and HLA‐DOA are Associated With Anti‐Tuberculosis Drug‐Induced Liver Injury Susceptibility and Clinical Manifestations in Western Chinese Populations

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Background Anti‐tuberculosis drug‐induced liver injury (ATDILI) is one of the most prevalent and serious adverse reactions during anti‐tuberculosis treatment and can potentially lead to liver failure or mortality. This study aims to investigate whether genetic variants in the N‐acetyltransferase 2 gene (NAT2) and the HLA‐DOA gene (HLA‐DOA) are
Zhenzhen Zhao, Dongmei Wang, Yanjun Si, Yanhong Zhou, Hongxia Ruan, Binwu Ying, Hao Chen   +6 more
wiley   +1 more source

Preventive chemotherapy in children exposed to multiple drug resistant tuberculosis

Туберкулез и болезни лёгких, 2019
The objective of the study: to assess the safety and efficacy of preventive anti-tuberculosis treatment of children exposed to multiple drug resistant tuberculosis (MDR TB) using different combinations of anti-tuberculosis drugs.Subjects and methods. 150
V. A. Аksenova, N. I. Klevno, A. V. Kazakov, A. V. Gordina, R. Kh. Fatykhova   +4 more
doaj   +1 more source

Isolated Central Nervous System Tuberculosis‐Associated Immune Reconstitution Inflammatory Syndrome—Case Report and Literature Review

Respirology Case Reports, Volume 14, Issue 9, September 2026.
Disseminated tuberculosis in an immunocompetent young male initially improved with anti‐tuberculosis therapy. Early treatment was complicated by drug‐induced liver injury and paradoxical isolated CNS‐TB‐IRIS with new intracranial lesions despite systemic disease regression.
Mithen Ravisankar, Muniza Bai, Vignesh Kumar Kathiresan, Jefferson Daniel Jawahar, Balamugesh Thangakunam, Angel Miraclin Thirugnanakumar, Elanthenral Sigamani   +6 more
wiley   +1 more source

SNPs leading to rifampicin, isoniazid and pyrazinamide resistance in XDR strains.

, 2015
All strain were resistant to rifampicin (RIF, 1 μg/ml), isoniazid (INH, 1 μg/ml) and pyrazinamide (PZA, 100μg/ml). ‘#’ mutations in the rifampicin- resistance determining region (RRDR), the number in parenthesis indicates the number of MTB isolates from ...
Mridul Nair (590036), Asho Ali (73920), Kim Mallard (362508), Taane G. Clark (106263), Rumina Hasan (73926), Zahra Hasan (73921), Ruth McNerney (227467), Francesc Coll (495630), Arnab Pain (37809), Grant Hill-Cawthorne (696209)   +9 more
core   +1 more source

Applicability of the shorter ‘Bangladesh regimen’ in high multidrug-resistant tuberculosis settings

International Journal of Infectious Diseases, 2017
In spite of the recent introduction of two new drugs (delamanid and bedaquiline) and a few repurposed compounds to treat multidrug-resistant and extensively drug-resistant tuberculosis (MDR- and XDR-TB), clinicians are facing increasing problems in ...
Giovanni Sotgiu, Simon Tiberi, Rosella Centis, Lia D’Ambrosio, Zhenia Fuentes, Alimuddin Zumla, Giovanni Battista Migliori   +6 more
doaj   +1 more source

Altered Pharmacokinetics and Delayed Sputum Conversion in Tuberculosis Patients Co‐Infected With HIV

Tropical Medicine &International Health, Volume 31, Issue 9, Page 1261-1272, September 2026.
ABSTRACT Background HIV co‐infection affects host responses and pharmacokinetics (PK) of tuberculosis (TB) treatment. This study assessed the PK of first‐line anti‐TB drugs and clinical outcomes in patients with and without HIV co‐infection. Methods In this prospective observational study, 61 adults with sputum‐positive pulmonary TB, either confirmed ...
Aung Pyae Phyo, Richard M. Hoglund, Makoto Saito, Sein Sein Thi, Lei Lei Swe, Palang Chotsiri, Htet Ko Ko Aung, Win Pa Pa Tun, Banyar Maung Maung, Chanapat Pateekham, Wanitda Watthanaworawit, Gornpan Gornsawun, Nicholas J. White, Francois Nosten, Joel Tarning   +14 more
wiley   +1 more source

Structural Modifications of Nonsteroidal Anti‐Inflammatory Drugs (NSAIDs): New Horizons in Antimicrobial Drug Discovery

Archiv der Pharmazie, Volume 359, Issue 8, August 2026.
This review provides a comprehensive analysis of the molecular modifications applied to NSAIDs to develop novel antimicrobial agents. By focusing on structural changes and their impact on biological activity, the study highlights innovative strategies to combat the global challenge of antimicrobial resistance.
Ebru Koçak Aslan, Ayşe Karagüzel, Miyase Gözde Gündüz   +2 more
wiley   +1 more source

Pyrazinoic acid efflux rate in Mycobacterium tuberculosis is a better proxy of pyrazinamide resistance

, 2012
Pyrazinamide is one of the most important drugs in the treatment of latent Mycobacterium tuberculosis infection. The emergence of strains resistant to pyrazinamide represents an important public health problem, as both first- and second-line treatment ...
Robert H. Gilman, Fuentes, Patricia, Gutierrez, Andres H., Daniela Kirwan, Sheen, Patricia, Mirko Zimic, Zimic, Mirko, Kirwan, Daniela, Patricia Fuentes, Patricia Sheen, Andrés H. Gutiérrez, Gilman, Robert H.   +11 more
core   +1 more source