Results 81 to 90 of about 14,172 (227)

Bifidobacterium adolescentis is resistant to pyrazinamide, isoniazid, and streptomycin

Scientific Reports
The current study aims to understand the resistance of Bifidobacterium adolescentis to different anti-tubercular drugs (first-line oral tuberculosis drugs). The bacteria were grown with anti-tubercular drugs such as isoniazid, pyrazinamide, and streptomycin to better understand the resistance phenomena.
Anagha Nellikka, Athira Cheruvari, Prasanna Vasu, Sarma Mutturi, Kammara Rajagopal   +4 more
openaire   +3 more sources

Pyrazinamide Resistance Assays and Two-Month Sputum Culture Status in Patients with Multidrug-Resistant Tuberculosis [PDF]

, 2016
Phenotypic drug susceptibility testing is the current gold standard for detecting Mycobacterium tuberculosis susceptibility to antituberculous drugs.
Contreras, Carmen C, Calderon, Roger, Murray, Megan B, Huang, Chuan-Chin, Yataco, Rosa M., Zhang, Zibiao, Mitnick, Carole D., Velásquez, Gustavo E., Becerra, Mercedes C, Galea, Jerome T, Lecca, Leonid   +10 more
core   +1 more source

Initial resistance to companion drugs should not be considered an exclusion criterion for the shorter multidrug-resistant tuberculosis treatment regimen

International Journal of Infectious Diseases, 2020
Objectives: We investigated whether companion drug resistance was associated with adverse outcomes of the shorter multidrug-resistant tuberculosis (MDR-TB) treatment regimen in Bangladesh after adjustment for fluoroquinolone resistance.
Pauline Lempens, Tom Decroo, Kya J.M. Aung, Mohammad A. Hossain, Leen Rigouts, Conor J. Meehan, Armand Van Deun, Bouke C. de Jong   +7 more
doaj   +1 more source

Thiazolidinedione–Pyrazolopyrimidinone Molecular Hybrids With Alkyl Spacers: Potential Antitubercular Agents Complemented by Molecular Modeling

ChemistrySelect, Volume 11, Issue 24, 25 June 2026.
We report the synthesis of 21 novel thiazolidinedione–pyrazolopyrimidinone derivatives (12a–u), prepared by coupling thiazolidinedione and pyrazolopyrimidinone pharmacophores through various alkyl linkers. The compounds were characterized spectroscopically and evaluated against the Mtb H37Rv strain, identifying compounds 5c and 5d as potent ...
Pule Seboletswe, Gobind Kumar, Nontobeko Gcabashe, Sanjeev Dhawan, Neha Manhas, Ankit, Audrey Jordaan, Digby F. Warner, Parvesh Singh   +8 more
wiley   +1 more source

Effects of mutations conferring pyrazinamide resistance among multidrug-resistant tuberculosis isolates from China

Microbiology Spectrum
To investigate the effects of mutations on pyrazinamide (PZA)-associated regions, including pncA, rpsA, panD, and clpC1, among multidrug-resistant tuberculosis (MDR-TB) isolates from China.
Xiang-long Bo, Ma-chao Li, Hao Hang, Shi-qiang Lin, Hai-can Liu, Cheng Qian, Gui-lian Li, Xiu-qin Zhao, Kang-Lin Wan, Li-li Zhao   +9 more
doaj   +1 more source

Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data.

PLoS Medicine, 2020
BackgroundThe surveillance of drug resistance among tuberculosis (TB) patients is central to combatting the global TB epidemic and preventing the spread of antimicrobial resistance. Isoniazid and rifampicin are two of the most powerful first-line anti-TB
Anna S Dean, Matteo Zignol, Andrea Maurizio Cabibbe, Dennis Falzon, Philippe Glaziou, Daniela Maria Cirillo, Claudio U Köser, Lice Y Gonzalez-Angulo, Olga Tosas-Auget, Nazir Ismail, Sabira Tahseen, Maria Cecilia G Ama, Alena Skrahina, Natavan Alikhanova, S M Mostofa Kamal, Katherine Floyd   +15 more
doaj   +1 more source

A Global Perspective on Pyrazinamide Resistance: Systematic Review and Meta-Analysis [PDF]

PLOS ONE, 2015
BackgroundPyrazinamide (PZA) is crucial for tuberculosis (TB) treatment, given its unique ability to eradicate persister bacilli. The worldwide burden of PZA resistance remains poorly described.MethodsSystematic PubMed, Science Direct and Scopus searches for articles reporting phenotypic (liquid culture drug susceptibility testing or pyrazinamidase ...
Michael G. Whitfield, Heidi M. Soeters, Robin M. Warren, Talita York, Samantha L. Sampson, Elizabeth M. Streicher, Paul D. van Helden, Annelies Van Rie   +7 more
openalex   +6 more sources

CYP2E1 and CYP2D6 in Anti‐Tuberculosis Drug‐Induced Liver Injury: Mechanisms, Epigenetic Regulation, and Translational Implications

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Tuberculosis (TB) continues to be a significant global health issue, with anti‐tuberculosis drug‐induced liver injury (ATDILI) representing the most frequent and severe adverse event associated with first‐line therapy. Despite extensive investigation, the mechanistic basis of ATDILI remains incompletely understood.
Pathida Prakongsup, Wanvisa Udomsinprasert   +1 more
wiley   +1 more source

Clinical Pharmacology Quality Assurance Program for Global HIV and Co‐Infection Drug Development

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1205-1215, May 2026.
When the acquired immunodeficiency syndrome emerged in the 1980s, the United States National Institutes of Health established research networks to conduct clinical trials with the pharmaceutical industry to identify effective antiretroviral therapeutics.
Robin DiFrancesco, Troy D. Wood, Raymond Cha, Jill S. Hochreiter, Susan L. Rosenkranz, Mona Farhad, Kyle R. Whitson, Connor E. Gould, Lauren E. Hill, Linda L. Hale, Philip H. Lindhorst, Diala Ghazal, Charlene R. Taylor, Madiha Quraishi, Suzanne M. Siminski, Yoninah Cramer, Heather L. Sprenger, Gene D. Morse   +17 more
wiley   +1 more source

The paradox of pyrazinamide: an update on the molecular mechanisms of pyrazinamide resistance in Mycobacteria.

The Journal of communicable diseases, 2007
Pyrazinamide (PZA) is an important front line anti-tuberculosis drug because of its sterilizing activity against semi-dormant tubercle bacilli. In spite of its remarkable role in shortening the treatment duration from 9 months to 6 months when used in combination with Rifampicin and Isoniazid, PZA remains a difficult paradox because of its incompletely
Pushpendra, Singh, A K, Mishra, S K, Malonia, D S, Chauhan, V D, Sharma, K, Venkatesan, V M, Katoch   +6 more
openaire   +1 more source