Results 91 to 100 of about 64,409 (320)

Recent Advances in Synthesis and Properties of Nitrated-Pyrazoles Based Energetic Compounds

Molecules, 2020
Nitrated-pyrazole-based energetic compounds have attracted wide publicity in the field of energetic materials (EMs) due to their high heat of formation, high density, tailored thermal stability, and detonation performance.
Shijie Zhang, Zhenguo Gao, Di Lan, Qian Jia, Ning Liu, Jiaoqiang Zhang, Kaichang Kou   +6 more
doaj   +1 more source

N\u3csup\u3e1\u3c/sup\u3e-Acetyl-3\u27-methylandrosta-4,16-dieno[16,17-\u3cem\u3ed\u3c/em\u3e]pyrazole-3-one [PDF]

, 1994
In an attempt to find the structural features promoting the thermal isomerization of the N-acylated steroid [16,17-d]pyrazoles into [17,16-c]pyrazole derivatives,the X-ray structure analysis of the title compound, C23H30N2O3, (1), has been carried out ...
Kamernitzky, Alexey V., Lindeman, Sergey V., Nava, Ezequiel Huipe, Skorova, Alina V., Vesela, Irina V., Yanovsky, Alexandr I.   +5 more
core   +1 more source

Probing binding and cellular activity of pyrrolidinone and piperidinone small molecules targeting the urokinase receptor [PDF]

, 2013
The urokinase receptor (uPAR) is a cell-surface protein that is part of an intricate web of transient and tight protein interactions that promote cancer cell invasion and metastasis. Here, we evaluate the binding and biological activity of a new class of
Knabe, William Eric, Li, Liwei, Liu, Degang, Mani, Timmy, Meroueh, Samy O., Oh, Kyungsoo, Wang, Fang, Zhou, Donghui   +7 more
core   +1 more source

An Elegant Method of One‐Pot Ligation‐Desulfurization for High‐Yielding Chemical Protein Synthesis

Advanced Science, EarlyView.
A one‐pot native chemical ligation and desulfurization method has been developed for efficient chemical protein synthesis. This unique approach uses bromoacetamide and N‐acetyl cysteine to selectively quench arylthiol post native chemical ligation.
Vishal Malik, Abhisek Kar, Anandh Muthiah Venkatachalam, Kalyaneswar Mandal   +3 more
wiley   +1 more source

Potent Fluorescent Probe for Target‐Engagement Studies of Allosteric Pyruvate Kinase Modulators

Angewandte Chemie, EarlyView.
LumiPK, a novel environment‐sensitive fluorescent tracer, enables direct monitoring of allosteric ligand engagement with pyruvate kinase fused with nanoluciferase (Nluc), focusing on the liver isoform (PKL). In NanoBRET, and fluorescence indicator displacement assays, LumiPK shows high affinity and validates known allosteric modulators of PKL.
Oscar Nilsson, Anna P. Valaka, Liliana Håversen, Agnieszka Bogucka, István Köteles, Paul Brear, Mikael Rutberg, Anders Gunnarsson, Marko Hyvönen, Morten Grøtli   +9 more
wiley   +2 more sources

3-Acetyl-5-phenyl-1-p-tolyl-1H-pyrazole-4-carbonitrile

Acta Crystallographica Section E, 2012
In the title pyrazole derivative, C19H15N3O, the central pyrazole ring makes dihedral angles of 42.71 (9) and 61.34 (9)°, respectively, with the phenyl and p-tolyl rings.
Hatem A. Abdel-Aziz, Hazem A. Ghabbour, Suchada Chantrapromma, Hoong-Kun Fun   +3 more
doaj   +1 more source

Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: Part 2. Synthesis of rigid pyrazolones [PDF]

, 2009
Two series of novel rigid pyrazolone derivatives were synthesized and evaluated as inhibitors of Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis. Two of these compounds showed a high activity against MTB (MIC = 4 μg/mL).
Alessandro De Logu, Beatrice Bechi, Biava, Biava, Biava, Brock, Castagnolo, Daniele Castagnolo, De Logu, Deidda, Fabrizio Manetti, Gutierrez-Lugo, Holzer, Janin, Mafalda Pagano, Manetti, Manuela Saddi, Marco Radi, Maurizio Botta, Rita Meleddu   +19 more
core   +1 more source

Dual‐Ligand Strategy in Rh‐Catalyzed Sequential Hydrofunctionalization of Valylene

Advanced Science, EarlyView.
A remarkable dual‐ligand strategy is employed in Rh‐catalyzed sequential coupling reaction of dinucleophiles and 1,3‐enynes with high regio‐ and chemo‐selectivity. Abstract Controlling regio‐ and chemo‐selectivity in transition‐metal‐catalyzed reactions involving coupling reagents with multiple reactive sites remains a significant challenge.
Yong‐Kang Mei, Su‐Yang Xu, Zhi‐Hui Wang, Ding‐Wei Ji, Qing‐An Chen   +4 more
wiley   +1 more source

Mechanistic Insight into Para‐Substituent Control of Thermal Half‐Lives in Arylazopyrazole Photoswitches

Angewandte Chemie, EarlyView.
Herein we provide an overview of photochromic and photophysical properties of a broad variety of arylazo‐1,3,5‐trimethylpyrazole photoswitches, including the influence of 23 different para‐substituents. Measured half‐lives correlated in a Hammet plot are rationalized by density functional theory calculations, revealing the underlying thermal ...
Katharina Schlögl, Nadja K. Singer, Dominik Dreier, Hubert Kalaus, Rafaela C. O. Conceição, Marko D. Mihovilovic, Leticia González   +6 more
wiley   +2 more sources

Aqua(4-nitrophthalato)bis[2-(1H-pyrazol-3-yl)pyridine]zinc(II) hemihydrate

Acta Crystallographica Section E, 2011
In the title compound, [Zn(C8H3NO6)(C8H7N3)2(H2O)]·0.5H2O, the ZnII atom shows a distorted octahedral ZnN4O2 coordination environment and is bonded to two 3-(2-pyridyl)-1H-pyrazole ligands via the N atoms, one monodentate 4-nitrophthalate ligand
Hong Wei, Ji-Li Zhao, Lei Ni
doaj   +1 more source