Results 151 to 160 of about 64,409 (320)

Coordination‐Driven Orthogonal Ligand Pairings through Dual Hydrogen‐Bonding/π‐π Interaction Complementarity

Chemistry – A European Journal, EarlyView.
A series of bidentate ligands for square‐planar Pd(II) complexes were developed, each with hydrogen‐bonding and π‐π‐stacking domains that are complementary to only one other ligand. The bis‐bidentate complexes form orthogonally to one another with high fidelity, but only when both interaction types are exploited in tandem.
Jordan N. Smith, Yolanda Yau, Nina R. Lawson, Rosemary J. Goodwin, Dan Preston   +4 more
wiley   +1 more source

The Fragmentation Reaction of 4-(7-Tropyl)pyrazoles by Bromination [PDF]

, 1964
Toshio Mukai, Haruki Tsuruta
openalex   +1 more source

Identification of a New Interesting BAG3 Modulator Able to Disrupt Cancer‐Related Pathways

ChemMedChem, EarlyView.
Compound 2, identified through in‐house screening and derived from SP18, exhibits high affinity for BAG3, as demonstrated by Surface Plasmon Resonance and docking studies. It induces a dose‐dependent proapoptotic response in HeLa cells, evidenced by increased Annexin V/PI staining, underscoring the triazole scaffold as a promising platform for BAG3 ...
Dafne Ruggiero, Eleonora Boccia, Emis Ingenito, Vincenzo Vestuto, Gilda D’Urso, Alessandra Capuano, Agostino Casapullo, Stefania Terracciano, Giuseppe Bifulco, Gianluigi Lauro, Ines Bruno   +10 more
wiley   +1 more source

Unveiling Benzoxazole‐Substituted Thiazolyl‐Pyrazole Derivatives Inducing Apoptosis by Targeting β‐Tubulin and Caspase‐3

ChemMedChem, EarlyView.
BP(1‐6) compounds designed from Benzoxazole and Thiazolyl‐Pyrazole scaffolds exhibited potent antitubulin and caspase‐3 activity in MDA‐MB‐231 cells. BP‐6 notably triggered apoptosis and disrupted cell proliferation. Docking studies validated strong binding affinities of BP‐2 and BP‐6 toward β‐tubulin and caspase‐3, suggesting promising therapeutic ...
Burak Kuzu, Mustafa Cakir, Eda Acikgoz, Mehmet Abdullah Alagoz   +3 more
wiley   +1 more source

Syntheses of Pyrazole Derivatives. I

, 1959
Akira Takamizawa, Sadao Hayashi
openalex   +2 more sources

Development of Novel Anticancer Pyrazolopyrimidinones Targeting Glioblastoma

ChemMedChem, EarlyView.
Pyrazolo[1,5‐α]pyrimidinone derivatives exhibit selective cytotoxicity towards glioblastoma (GBM) cells over noncancerous cells. Structure–activity relationship studies identifies a lead compound with significant cytotoxicity activity, inducing apoptosis and necrosis in GBM cells, without affecting noncancerous cells. This demonstrates the potential of
Kate Byrne, Natalia Bednarz, Ciara McEvoy, John C. Stephens, James F. Curtin, Gemma K. Kinsella   +5 more
wiley   +1 more source

Molecular Docking and Target‐Specific Binding Profiles of Benzosuberane‐Based Compounds

ChemMedChem, EarlyView.
Benzosuberane represents a promising scaffold in medicinal chemistry. Several benzosuberane‐based derivatives are described in this review as anticancer agents, including antivascular agents, DNA‐intercalators, receptor modulators and kinase inhibitors.
Michail A. Saragatsis, Gemma K. Kinsella, James F. Curtin, Tao Zhang   +3 more
wiley   +1 more source

Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry

ChemMedChem, EarlyView.
This review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Sadık Hüseyin Cemali, Samet Poyraz, Samet Belveren, Senanur Taş, Mehmet Ali Tamer, Naciye Yaktubay Döndaş, H. Ali Döndaş, Jose Miguel Sansano   +7 more
wiley   +1 more source

Some Substituted 1H,4H- and 1H,5H-Pyrazolo[4,3-c]pyrazoles. Syntheses and Properties [PDF]

, 1974
Joung Hee Lee, Akira Matsumoto, Masayuki Yoshida, Osamu Simamura   +3 more
openalex   +1 more source

Human Liver Alcohol Dehydrogenase: Inhibition by Pyrazole and Pyrazole Analogs. [PDF]

Acta Chemica Scandinavica, 1969
Ting-Kai Li, Hugo Theorell, Charles Larsen, Per Halfdan Nielsen, Alf A. Lindberg, Gert Jansen, Bo Lamm, Benny Samuelsson   +7 more
openaire   +3 more sources