Results 161 to 170 of about 64,409 (320)

Novel Pyrazolo [1,5‐a]−1,3,5‐Triazine Derivatives as CDK7 Inhibitors: Synthesis and Biological Insights in Pancreatic Ductal Adenocarcinoma Models

ChemMedChem, EarlyView.
Pyrazolo [1,5‐a]−1,3,5‐triazine derivatives efficiently synthesized showed remarkable cytotoxicity and inhibition of cell migration in PDAC models. They induced apoptosis, upregulated apoptotic gene expression, and disrupted the cell cycle, significantly reducing the viability of spheroidal PATU‐T cultures.
Daniela Carbone, Francesca Terrana, Ludovica Sciuto, Camilla Pecoraro, Geng Xu, Stella Cascioferro, Girolamo Cirrincione, Godefridus J. Peters, Elisa Giovannetti, Barbara Parrino, Patrizia Diana   +10 more
wiley   +1 more source

Studies on Fungicides. VII. Synthesis and Antifungal Activity of Some Pyrazole Derivatives.

, 1964
Jiro Kinugawa, Michihiko Ochiai, Chikashi Matsumura, Hiroichi Yamamoto   +3 more
openalex   +2 more sources

How to (not) Evaluate a Photoswitch Performance; Benchmarking of Methods Used for Processing Kinetic Data on an Example of Arylazopyrazole Z‐Isomer Half‐Life

Chemistry–Methods, EarlyView.
The key parameter for characterization of novel photoswitches is a half‐life of the metastable form. However, processing one kinetic data set by different approaches used in literature leads to a wide range of the half‐lives with up to 25% deviation, which may cause significant inconsistencies when comparing the photoswitchable systems.
Anna Hruzíková, Aleš Růžička, Eliška Procházková   +2 more
wiley   +1 more source

Fluxional Behavior of Palladium(II) and Platinum(II) Complexes Containing both a Metal–Aryl Bond and a Pyrazole-derived Ligand [PDF]

, 1978
Masayoshi Onishi, Koji Sugimura, Katsuma Hiraki   +2 more
openalex   +1 more source

Accurate and Rapid Ranking of Protein–Ligand Binding Affinities Using Density Matrix Fragmentation and Physics‐Informed Machine Learning Dispersion Potentials

ChemPhysChem, EarlyView.
Two efficient methods, generalized many‐body expansion for building density matrices (GMBE‐DM) and D3‐ML, are introduced for ranking protein–ligand binding affinities. GMBE‐DM delivers quantum‐accurate results within minutes, while D3‐ML achieves even higher accuracy in under one second per complex.
Ka Un Lao, Danyang Wang
wiley   +1 more source

Syntheses of Pyrazole Derivatives. III

, 1963
Akira Takamizawa, Sadao Hayashi
openalex   +2 more sources

A Neutron Diffraction Study of the Crystal and Molecular Structure of Pyrazole, C3H4N2. [PDF]

, 1970
Finn Larsen, M. S. Lehmann, Inger Søtofte, Svend Erik Rasmussen, Akira Shimizu   +4 more
openalex   +1 more source

Sustainable Hydrogen Production by Glycerol and Monosaccharides Catalytic Acceptorless Dehydrogenation (AD) in Homogeneous Phase

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
Sustainable hydrogen production can be obtained from hydogen‐rich biomass‐derived organic molecules through Acceptorless Dehydrogenation (AD) reactions. Glycerol and sugars are available in large quantities from industry and can be successfully used as substrates in AD protocols, in the presence of tailored, selective, easily tunable and thermally ...
Sylwia Kostera, Luca Gonsalvi
wiley   +1 more source

Syntheses of Pyrazole Derivatives. VI

, 1963
Akira Takamizawa, Yoshio Hamashima, Sadao Hayashi, Ryonosuke Kido   +3 more
openalex   +2 more sources

Amidrazones and Related Compounds. V. The Formation of Pyrazole, 1H-1,2,4-Triazepine, and 4H,11H-[1,5]Diazocino-[2,3-e: 6,7-e′]di[1H-1,2,4]triazepine Derivatives [PDF]

, 1977
Masahīko Takahashi, Noriyuki Sugawara, Kaoru Yoshimura   +2 more
openalex   +1 more source