Results 81 to 90 of about 19,589 (195)

Engineering of 2‐ketoacid Decarboxylases for Production of Isobutanol and Other Fusel Alcohols in Saccharomyces cerevisiae

Biotechnology and Bioengineering, Volume 123, Issue 4, Page 1036-1049, April 2026.
ABSTRACT Isobutanol is a fusel alcohol that can be produced microbially for use as a biofuel or upgraded into sustainable aviation fuel (SAF). A key enzyme in the isobutanol biosynthetic pathway is 2‐ketoacid decarboxylase (KDC), which irreversibly decarboxylates 2‐ketoisovalerate (KIV) to yield isobutyraldehyde.
Joshua J. Dietrich, Maelia Dziedzic, Jia Sun, Sri Harsha Adusumilli, Carla Gonçalves, Chris Todd Hittinger, Brian F. Pfleger   +6 more
wiley   +1 more source

Synthesis of pyrazole and pyrazoline derivatives of β-ionone: Exploring anti-inflammatory potential, cytotoxicity, and molecular docking insights

European Journal of Medicinal Chemistry Reports
In the present paper, pyrazole and pyrazoline derivatives of β-ionone were synthesized. The protocol involved intramolecular oxidative C–H amination of hydrazone to yield corresponding pyrazole in moderate to good yields.
Monika Sihag, Anju Manuja, Swati Rani, Rinku Soni, Neha Rani, Sandeep Malik, Kirti Bhardwaj, Balvinder Kumar, Mayank Kinger, Monika Miglani, Deepak Kumar Aneja   +10 more
doaj   +1 more source

Pravastatin Corrects Endothelial Dysfunction in Ex Vivo Uterine Radial Arteries in Preeclampsia

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Endothelium‐dependent relaxation in isolated uterine radial arteries from normotensive (NT) and preeclamptic (PE) pregnancies, and the acute effects of pravastatin in the latter vessels were assessed. Pravastatin is hypothesized to alleviate endothelial dysfunction in PE via modulating aspects of NO and endothelium‐derived ...
Nathan M. Luque, Leo Leader, Sandra M. Lowe, Steven D. Horrowitz, Marianne Tare, Victoria Hinkley, Vladimir V. Matchkov, Maged M. Costantine, Irit Markus, Lu Liu, Shaun L. Sandow, Timothy V. Murphy   +11 more
wiley   +1 more source

Visible‐Light Mediated Functionalization in Phe‐Containing Peptides Upon a Debenzylative Amination Process

Advanced Synthesis &Catalysis, Volume 368, Issue 6, 17 March 2026.
Selective late‐stage modification of N‐terminal phenylalanine short peptides is achived by visible‐light initiated reaction with N‐iodoimides in a debenzylation–amination process. This metal‐free method permits the incorporation of N‐containing heterocycles into the α‐position of the peptide backbone.
Guillermo Morales‐Ortega, Iván Pérez‐Cubero, Enrique Gómez‐Bengoa, Arkaitz Correa, Javier Carreras   +4 more
wiley   +1 more source

Electro‐Mediated Redox Functionalization of Conjugated 1,3‐Dienes

Advanced Synthesis &Catalysis, Volume 368, Issue 6, 17 March 2026.
This review aims at providing a comprehensive view of the emerging field of electro‐mediated functionalization of conjugated 1,3‐dienes, highlighting key developments, mechanistic insights, and remaining challenges. It highlights the efficient use of electron as the sole reagent to access highly substituted allylic compounds from simple and readily ...
Ophélie Montiège, Jean‐François Brière, Cédric Schneider, Hélène Beucher   +3 more
wiley   +1 more source

Enhanced CO Selectivity in CO2 Electroreduction on Pyrazole‐Modified Boron‐Doped Diamond Electrodes

ChemElectroChem, Volume 13, Issue 6, 17 March 2026.
Electrochemical CO2 reduction is demonstrated using molecularly modified boron‐doped diamond electrodes. Pyrazole modification doubles the CO selectivity compared to the previous aniline‐modified surface. This enhancement arises from the synergistic effect of the adjacent nitrogen atoms in pyrazole, which provides both high nucleophilicity for CO2 ...
Ekitomo Oh, Yasuaki Einaga, Takashi Yamamoto   +2 more
wiley   +1 more source

Bis‐Furans: A Sustainable Source of Diverse Molecular Architectures

European Journal of Organic Chemistry, Volume 29, Issue 10, 9 March 2026.
A concise synthetic route to diverse acyclic and heterocyclic compounds has been developed by combining hetero‐Diels–Alder reactions, DBU‐promoted ring openings, and Lewis base‐catalyzed annulations. Nitrosoalkenes reacted with furan derivatives to form 4a,7a‐dihydro‐4H‐furo[2,3‐e][1,2]oxazines, which underwent DBU‐promoted rearrangements to 6H‐1,2 ...
Ana L. Cardoso, José A. Paixão, Teresa M. V. D. Pinho e Melo   +2 more
wiley   +1 more source

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

Advanced Healthcare Materials, Volume 15, Issue 9, 6 March 2026.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche, Andreas Dzierza, Jan Egger, Timo Rheinberger, Christin Weilandt, Frederik R. Wurm, Ivo Nischang, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

Copper pyrazole addition regulates soil mineral nitrogen turnover by mediating microbial traits

Frontiers in Microbiology
The huge amount of urea applied has necessitated best-developed practices to slow down the release of nitrogen (N) fertilizer while minimizing nitrate loss.
Yuming Wang, Yuming Wang, Yuming Wang, Wenling Zhong, Wenling Zhong, Wenling Zhong, Xiwen Zhang, Xiwen Zhang, Xiwen Zhang, Minghui Cao, Minghui Cao, Zheng Ni, Zheng Ni, Zheng Ni, Mengxia Zhang, Mengxia Zhang, Mengxia Zhang, Jiangye Li, Yan Duan, Yan Duan, Lifang Wu, Lifang Wu   +21 more
doaj   +1 more source

Crystal Engineering of Reticular Materials for Gas‐ and Liquid‐Phase Hydrocarbon Separation

Advanced Materials, Volume 38, Issue 16, 17 March 2026.
Crystal engineering enables systematic study of structure/function relationships as exemplified by pore engineering of reticular sorbents, including porous coordination networks and covalent organic frameworks. This review assesses such studies applied across the full scope of industrially relevant hydrocarbon separations to provide insight into how ...
Xia Li, Soumya Mukherjee, Michael J. Zaworotko   +2 more
wiley   +1 more source