Results 81 to 90 of about 64,409 (320)
Angewandte Chemie, EarlyView.This work demonstrates an unconventional mechanism in Lewis basic selenium‐catalyzed electrophilic halogenation, where in situ oxidation of selenourea by the halogen source generates hypervalent Se‐imidazolium species. These intermediates function as hydrogen‐bond catalysts to activate N‐haloamide reagents, enabling efficient and mild halogenation of ...
Jingxian Huang +6 more
wiley +2 more sources
Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities [PDF]
, 2017 Dengue virus (DENV) is the leading mosquito-transmitted viral infection in the world. With more than 390 million new infections annually, and up to 1 million clinical cases with severe disease manifestations, there continues to be a need to develop new ...
Coluccia, A. +9 more
core +1 more source
Advanced Science, EarlyView.This work presents a strategy for preparing energetic composites based on energetic metal‐organic frameworks and MXene. This approach leverages the interfacial “Ti─O···Cu” non‐bonded interactions to achieve energetic composites with diverse morphologies and performance.
Ke‐Juan Meng +6 more
wiley +1 more source
Angewandte Chemie, EarlyView.Fe‐triazolate (Fe(ta)2) and its metal‐substituted derivatives (Fe‐Metal(ta)2) MOFs are reported as dual‐function materials for light absorption and water oxidation catalysis in acidic media, achieving a highest photocurrent of 2 × 10−3 A cm−2 at bias + 1.4 V vs. Ag/AgCl.
Jully Patel +6 more
wiley +2 more sources
(E)-1-(3,4-Dimethoxyphenyl)-3-(1,3-diphenyl-1H-pyrazol-4-yl)prop-2-en-1-one
IUCrDataIn the title compound, C26H22N2O3, the dihedral angle between the benzene and pyrazole rings of the chalcone unit is 88.3 (1)°. The pyrazole ring has two attached phenyl rings that form dihedral angles with the pyrazole ring of 22.6 (2) and 40.0 (1)°. In
Jiha Sung
doaj +1 more source
Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review
Molecules, 2018 Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities.
Khalid Karrouchi +6 more
doaj +1 more source
Sydnone Cycloaddition Route to Pyrazole-Based Analogs of Combretastatin A4. [PDF]
, 2016 The combretastatins are an important class of tubulin-binding agents. Of this family, a number of compounds are potent tumor Vascular Disrupting Agents (VDAs) and have shown promise in the clinic for cancer therapy.
Brown, A.W. +4 more
core +2 more sources
Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities
Advanced Science, EarlyView.The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active state through phosphorylation, oligomerization, membrane recruitment, and membrane insertion, ultimately forming membrane hotpots.
Lijuan Xu, Chunlin Zhuang
wiley +1 more source
Umpolung Activation of Bicyclobutanes via N‐Heterocyclic Carbene Catalysis
Angewandte Chemie, EarlyView.NHC‐catalyzed umpolung of bicyclo[1.1.0]butane (BCB) aldehydes enables nucleophilic cycloaddition with carbonyls and imines to form bicyclic lactones and lactams. The resulting oxa‐ and aza‐bicyclo[3.1.1]heptane products can be further transformed into valuable rigid 3D scaffolds, offering a simple and versatile approach to access new chemical space ...
Yu‐Che Chang +5 more
wiley +2 more sources
1,1′-Bis(1-acetyl-5-methyl-1H-pyrazol-3-yl)ferrocene
Acta Crystallographica Section E, 2011 The title compound, [Fe(C11H11N2O)2], crystallizes with two independent molecules in the asymmetric unit which have have different conformations. In one molecule, the two ferrocene cyclopentadienyl rings are fully eclipsed and the two pyrazole rings are ...
Bei-Bei Zhu +3 more
doaj +1 more source