Results 121 to 130 of about 38,574 (278)

A Neutron Diffraction Study of the Crystal and Molecular Structure of Pyrazole, C3H4N2. [PDF]

, 1970
Finn Larsen, M. S. Lehmann, Inger Søtofte, Svend Erik Rasmussen, Akira Shimizu   +4 more
openalex   +1 more source

Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry

ChemMedChem, EarlyView.
This review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Sadık Hüseyin Cemali, Samet Poyraz, Samet Belveren, Senanur Taş, Mehmet Ali Tamer, Naciye Yaktubay Döndaş, H. Ali Döndaş, Jose Miguel Sansano   +7 more
wiley   +1 more source

Syntheses of Pyrazole Derivatives. VI

, 1963
Akira Takamizawa, Yoshio Hamashima, Sadao Hayashi, Ryonosuke Kido   +3 more
openalex   +2 more sources

Amidrazones and Related Compounds. V. The Formation of Pyrazole, 1H-1,2,4-Triazepine, and 4H,11H-[1,5]Diazocino-[2,3-e: 6,7-e′]di[1H-1,2,4]triazepine Derivatives [PDF]

, 1977
Masahīko Takahashi, Noriyuki Sugawara, Kaoru Yoshimura   +2 more
openalex   +1 more source

Novel Pyrazolo [1,5‐a]−1,3,5‐Triazine Derivatives as CDK7 Inhibitors: Synthesis and Biological Insights in Pancreatic Ductal Adenocarcinoma Models

ChemMedChem, EarlyView.
Pyrazolo [1,5‐a]−1,3,5‐triazine derivatives efficiently synthesized showed remarkable cytotoxicity and inhibition of cell migration in PDAC models. They induced apoptosis, upregulated apoptotic gene expression, and disrupted the cell cycle, significantly reducing the viability of spheroidal PATU‐T cultures.
Daniela Carbone, Francesca Terrana, Ludovica Sciuto, Camilla Pecoraro, Geng Xu, Stella Cascioferro, Girolamo Cirrincione, Godefridus J. Peters, Elisa Giovannetti, Barbara Parrino, Patrizia Diana   +10 more
wiley   +1 more source

Studies on Indole Derivatives. III. : Synthesis of 3'-Phenylspiro-[2-oxoindoline-3, 5'-pyrazole]Derivatives

, 1966
Goro Kobayashi, S. FURUKAWA, Yoshiro Matsuda   +2 more
openalex   +2 more sources

How to (not) Evaluate a Photoswitch Performance; Benchmarking of Methods Used for Processing Kinetic Data on an Example of Arylazopyrazole Z‐Isomer Half‐Life

Chemistry–Methods, EarlyView.
The key parameter for characterization of novel photoswitches is a half‐life of the metastable form. However, processing one kinetic data set by different approaches used in literature leads to a wide range of the half‐lives with up to 25% deviation, which may cause significant inconsistencies when comparing the photoswitchable systems.
Anna Hruzíková, Aleš Růžička, Eliška Procházková   +2 more
wiley   +1 more source

Synthesis of Novel Tetra-Substituted Pyrazole Derivatives Using Microwave Irradiation and Their Anti-Leukemic Activity Against Jurkat Cells. [PDF]

Molecules
Machado FP, Campos MC, Echevarria-Lima J, Sangi DP, Serpa C, Chaves OA, Echevarria A.   +6 more
europepmc   +1 more source

Syntheses of Pyrazole Derivatives. VIII

, 1965
Akira Takamizawa, Sadao Hayashi, Hisao Satô   +2 more
openalex   +2 more sources

Accurate and Rapid Ranking of Protein–Ligand Binding Affinities Using Density Matrix Fragmentation and Physics‐Informed Machine Learning Dispersion Potentials

ChemPhysChem, EarlyView.
Two efficient methods, generalized many‐body expansion for building density matrices (GMBE‐DM) and D3‐ML, are introduced for ranking protein–ligand binding affinities. GMBE‐DM delivers quantum‐accurate results within minutes, while D3‐ML achieves even higher accuracy in under one second per complex.
Ka Un Lao, Danyang Wang
wiley   +1 more source