Results 51 to 60 of about 20,708 (225)
Cu-catalysed pyrazole synthesis in continuous flow [PDF]
The synthesis of 1,4-disubstituted pyrazoles via the cycloaddition reaction of sydnones and terminal alkynes has been achieved employing silica-supported copper catalysts. Furthermore, this methodology has been successfully implemented in continuous flow
Arbaciauskiené+26 more
core +3 more sources
Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides [PDF]
An efficient method for the palladium-catalyzed amination of unprotected bromoimidazoles and bromopyrazoles is presented. The transformation is facilitated by the use of our newly developed Pd precatalyst based on the bulky biarylphosphine ligand ...
Buchwald, Stephen Leffler+2 more
core +1 more source
An Update: Enzymatic Synthesis for Industrial Applications
Biocatalysis has become a sustainable and cost‐competitive alternative to established chemical synthesis, enabling the enzyme‐based production of not only commodity chemicals but (non‐natural) amino acids, (rare) sugars, as well as synthetic nucleotides.
Thomas Bayer+4 more
wiley +1 more source
Vilsmeier-Haack reagent: A facile synthesis of 2-(4-chloro-3,3-dimethyl-7-phenoxyindolin-2-ylidene)malonaldehyde and transformation into different heterocyclic compounds [PDF]
2-(5-Chloro-2-phenoxyphenyl)hydrazine was converted to corresponding 3H-indole by Fischer method utilizing the isopropyl methyl ketone in acetic acid.
Arash Afghan+2 more
core +1 more source
The graphical abstract shows the principal results of this study. Eight major aroma‐contributing compounds (nonanal, octanal, dimethyl tetrasulfide, hexanal, 1‐octen‐3‐ol, (E)‐2‐nonenal, heptanal, and (E,E)‐2,4‐decadienal) were identified by electronic nose and GC‐O‐MS analysis, and their content increased with age.
Yanke Wang+6 more
wiley +1 more source
A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process. [PDF]
A versatile multistep continuous flow setup is reported for the four-step conversion of anilines into pyrazole products. The synthesis machine incorporates the use of amine-redox chemistry through diazotization and a metal-free vitamin C mediated ...
Browne, Duncan L+2 more
core +5 more sources
Pharmacology and relevant drug interactions of metamizole
Metamizole is a frequently prescribed analgesic because of its favourable benefit/risk ratio compared with classic NSAIDs. However, increasing research shows that metamizole displays several drug interactions that are relevant to clinical practice. We reviewed the literature to summarize the pharmacology and most clinically relevant drug interactions ...
David J. Brinkman+3 more
wiley +1 more source
Given the essential role of protein‐protein interactions (PPIs) in cellular signalling pathways their selective modulation is of great therapeutic interest. Mimicry of secondary structural protein elements has emerged as a promising strategy, with various scaffolds reproducing recognition surfaces of α‐helical and β‐strand/sheet proteins.
James Luccarelli+4 more
wiley +1 more source
Catalysis in Chemical Modification of Proteins
Catalytic principles of synthetic organic chemistry have been increasingly applied to chemical modification of proteins during the recent years. This review article describes how seven types of catalytic systems —electrocatalysis, photocatalysis, metal catalysis, acid catalysis, organocatalysis, supramolecular catalysis, and heterogeneous catalysis ...
Seiya Ishizawa+4 more
wiley +1 more source
Transfer Hydrogenation to Bicarbonate Salts and CO2 Catalyzed by IrCp*‐Oxyquinolinate Complexes
[IrClCp*(QO)] complexes are efficient catalysts for the transfer hydrogenation of CO₂ and bicarbonate salts under mild conditions. This process enables formate production without hazardous H₂ gas, highlighting the role of ligand design in catalytic performance.
Kevin Gutiérrez+3 more
wiley +1 more source