Results 51 to 60 of about 20,708 (225)

Cu-catalysed pyrazole synthesis in continuous flow [PDF]

open access: yes, 2016
The synthesis of 1,4-disubstituted pyrazoles via the cycloaddition reaction of sydnones and terminal alkynes has been achieved employing silica-supported copper catalysts. Furthermore, this methodology has been successfully implemented in continuous flow
Arbaciauskiené   +26 more
core   +3 more sources

Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides [PDF]

open access: yes, 2013
An efficient method for the palladium-catalyzed amination of unprotected bromoimidazoles and bromopyrazoles is presented. The transformation is facilitated by the use of our newly developed Pd precatalyst based on the bulky biarylphosphine ligand ...
Buchwald, Stephen Leffler   +2 more
core   +1 more source

An Update: Enzymatic Synthesis for Industrial Applications

open access: yesAngewandte Chemie International Edition, EarlyView.
Biocatalysis has become a sustainable and cost‐competitive alternative to established chemical synthesis, enabling the enzyme‐based production of not only commodity chemicals but (non‐natural) amino acids, (rare) sugars, as well as synthetic nucleotides.
Thomas Bayer   +4 more
wiley   +1 more source

Vilsmeier-Haack reagent: A facile synthesis of 2-(4-chloro-3,3-dimethyl-7-phenoxyindolin-2-ylidene)malonaldehyde and transformation into different heterocyclic compounds [PDF]

open access: yes, 2013
2-(5-Chloro-2-phenoxyphenyl)hydrazine was converted to corresponding 3H-indole by Fischer method utilizing the isopropyl methyl ketone in acetic acid.
Arash Afghan   +2 more
core   +1 more source

Characterization of the pattern of development of key compounds contributing to aroma quality of chicken meat and their metabolic markers

open access: yesAnimal Research and One Health, EarlyView.
The graphical abstract shows the principal results of this study. Eight major aroma‐contributing compounds (nonanal, octanal, dimethyl tetrasulfide, hexanal, 1‐octen‐3‐ol, (E)‐2‐nonenal, heptanal, and (E,E)‐2,4‐decadienal) were identified by electronic nose and GC‐O‐MS analysis, and their content increased with age.
Yanke Wang   +6 more
wiley   +1 more source

A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process. [PDF]

open access: yes, 2015
A versatile multistep continuous flow setup is reported for the four-step conversion of anilines into pyrazole products. The synthesis machine incorporates the use of amine-redox chemistry through diazotization and a metal-free vitamin C mediated ...
Browne, Duncan L   +2 more
core   +5 more sources

Pharmacology and relevant drug interactions of metamizole

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Metamizole is a frequently prescribed analgesic because of its favourable benefit/risk ratio compared with classic NSAIDs. However, increasing research shows that metamizole displays several drug interactions that are relevant to clinical practice. We reviewed the literature to summarize the pharmacology and most clinically relevant drug interactions ...
David J. Brinkman   +3 more
wiley   +1 more source

A Polyproline type II Peptidomimetic Disrupts a Grb2 SH3C Domain Protein‐protein Interaction Implicated in Breast Cancer

open access: yesChemBioChem, Accepted Article.
Given the essential role of protein‐protein interactions (PPIs) in cellular signalling pathways their selective modulation is of great therapeutic interest. Mimicry of secondary structural protein elements has emerged as a promising strategy, with various scaffolds reproducing recognition surfaces of α‐helical and β‐strand/sheet proteins.
James Luccarelli   +4 more
wiley   +1 more source

Catalysis in Chemical Modification of Proteins

open access: yesChemCatChem, EarlyView.
Catalytic principles of synthetic organic chemistry have been increasingly applied to chemical modification of proteins during the recent years. This review article describes how seven types of catalytic systems —electrocatalysis, photocatalysis, metal catalysis, acid catalysis, organocatalysis, supramolecular catalysis, and heterogeneous catalysis ...
Seiya Ishizawa   +4 more
wiley   +1 more source

Transfer Hydrogenation to Bicarbonate Salts and CO2 Catalyzed by IrCp*‐Oxyquinolinate Complexes

open access: yesChemCatChem, EarlyView.
[IrClCp*(QO)] complexes are efficient catalysts for the transfer hydrogenation of CO₂ and bicarbonate salts under mild conditions. This process enables formate production without hazardous H₂ gas, highlighting the role of ligand design in catalytic performance.
Kevin Gutiérrez   +3 more
wiley   +1 more source

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