Results 71 to 80 of about 27,892 (233)

Ultrasound-promoted iodination of pyrazoles in aqueous medium

Orbital: The Electronic Journal of Chemistry, 2012
Several pharmacological activities have been devoted to pyrazole containing molecules. In particular, 4-iodopyrazoles have been employed as key starting materials in cross-coupling chemistry and metal-iodine exchange reactions that focus on the synthesis
Jéssica Kunsminskas, Lucas Pizutti, Cristiano Raminelli   +2 more
doaj   +1 more source

Advances in Mechanochemical Methods for One‐Pot Multistep Organic Synthesis

Chemistry – A European Journal, Accepted Article.
Mechanochemical synthesis has emerged as a powerful and more sustainable alternative to conventional solution‐based methods, offering advantages such as no or only minimal solvent use, reduced reaction times, and simplified operational conditions.
Michael Schnürch, Nina Biedermann
wiley   +1 more source

A Sydnonimine‐based Click‐and‐Release Approach to Cyclic Products

Chemistry – A European Journal, EarlyView.
Macrocyclick‐and‐release: The combination of a chemoselective Cu‐catalyzed click‐and‐release reaction and pyrene tags allows efficient synthesis of macrocycles and easy isolation by simple filtration through graphitic material. Abstract Herein, we report a general, efficient, and practical methodology for the macrocyclization of compounds based on the ...
Guillaume Force, Minghao Feng, Davide Audisio, Pierre Thuéry, Emmanuelle Schulz, Frédéric Taran   +5 more
wiley   +1 more source

Synthesis and Antimicrobial Activity of Some New Pyrazoles, Fused Pyrazolo[3,4-d]-pyrimidine and 1,2-Dihydroimidazo-[2,1-c][1,2,4]triazin-6-one Derivatives

Molecules, 2011
A novel series of 7,7-diphenyl-1,2-dihydroimidazo[2,1-c][1,2,4]triazin-6(7H)-one 6a–h, were easily prepared via reactions of novel 2-hydrazinyl-4,4-diphenyl-1H-imidazol-5(4H)-one (2) with hydrazonoyl halides 3a–h.
Huwaida M.E. Hassaneen, Sobhi Mohamed Gomha   +1 more
doaj   +1 more source

Further Structure‐Activity Relationship of G Protein‐Gated Inwardly Rectifying Potassium Channels 1/2 Activators: Synthesis and Biological Characterization of In Vitro Tool Compounds

ChemMedChem, EarlyView.
Work presented here details the design and characterize novel G protein‐gated inwardly rectifying potassium channels (GIRK)1/2 activators. A new 4,4‐difluorocyclohexylpyrazole have been identified that confers improved potency and selectivity for GIRK1/2 versus GIRK1/4.
Sumaiya Nahid, Fahad Imtiaz Rahman, Yu Du, Brittany D. Spitznagel, Sandeep K. Singh, Yashpal S. Chhonker, Daryl J. Murry, C. David Weaver, Corey R. Hopkins   +8 more
wiley   +1 more source

5-(2,3-Dichlorophenyl)-3-(4-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole

IUCrData, 2017
In the racemic title compound, C22H18Cl2N2O, the dihedral angles between the central dihydropyrazole ring (r.m.s. deviation = 0.018 Å) and the pendant methoxyphenyl, phenyl and dichlorophenyl rings are 3.96 (9), 15.90 (9) and 66.65 (9)° respectively ...
D. M. Lokeshwari, S. Naveen, M. G. Prabhudeva, K. R. Raghavendra, A. Dileep Kumar, N. K. Lokanath, K. Ajay Kumar   +6 more
doaj   +1 more source

Pyrazole Studies. XII. Hydrazobenzene-catalysed Oxidation of 1:2-Diphenyl-4-butylpyrazolidine-3,5-dione (Butazolidine). [PDF]

, 1958
Stig Veibel, Søren Linholter, Poul Ejnar Sørensen, Lars Svennerholm, Lars Ernster, E. Diczfalusy   +5 more
openalex   +1 more source

Is Mycobacterial InhA a Suitable Target for Rational Drug Design?

ChemMedChem, EarlyView.
InhA is the target of isoniazid, a first‐line antituberculosis drug. Isoniazid is, in fact, a prodrug that needs to be activated. Researchers are trying to develop direct inhibitors of InhA. This includes the resolution of crystallographic structures. The Protein Data Bank contains over a hundred InhA structures.
Julien Rizet, Laurent Maveyraud, David Rengel, Valérie Guillet, Gabriel Publicola, Frédéric Rodriguez, Christian Lherbet, Lionel Mourey   +7 more
wiley   +1 more source

Identification of novel pyrazole and benzimidazole based derivatives as PBP2a inhibitors: Design, synthesis, and biological evaluation

Archives of Pharmaceutical Sciences Ain Shams University, 2019
The antibiotic resistance of methicillin-resistant Staphylococcus aureus (MRSA) is attributable to the expression of the high molecular mass transpeptidase enzyme, penicillin-binding protein 2a (PBP2a), an enzyme that catalyzes the cross-linking reaction
Menna-Allah W. Shalaby, Eman M.E. Dokla, Rabah A. T. Serya, Khaled A. M. Abouzid   +3 more
doaj   +1 more source

THE REACTIONS OF THE FORMAMIDINES. IX. THE SYNTHESIS OF 5-PHENYL-4-PYRAZOLE CARBOXYLIC ACID. [PDF]

, 1921
F. B. Dains, Wang Long
openalex   +1 more source