Results 1 to 10 of about 4,108 (208)

Trifluoromethylated hydrazones and acylhydrazones as potent nitrogen-containing fluorinated building blocks [PDF]

Beilstein Journal of Organic Chemistry, 2023
Nitrogen-containing organofluorine derivatives, which are prepared using fluorinated building blocks, are among the most important active fragments in various pharmaceutical and agrochemical products. This review focuses on the reactivity, synthesis, and
Zhang Dongxu
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De Novo Design of Imidazopyridine-Tethered Pyrazolines That Target Phosphorylation of STAT3 in Human Breast Cancer Cells [PDF]

Bioengineering, 2023
In breast cancer (BC), STAT3 is hyperactivated. This study explored the design of imidazopyridine-tethered pyrazolines as a de novo drug strategy for inhibiting STAT3 phosphorylation in human BC cells.
Akshay Ravish, Rashmi Shivakumar, Zhang Xi, Min Hee Yang, Ji-Rui Yang, Ananda Swamynayaka, Omantheswara Nagaraja, Mahendra Madegowda, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Vijay Pandey, Gautam Sethi, Kwang Seok Ahn, Peter E. Lobie, Basappa Basappa   +14 more
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The Role of Flow Chemistry on the Synthesis of Pyrazoles, Pyrazolines and Pyrazole-Fused Scaffolds [PDF]

Molecules
Nitrogen-containing heterocycles are fundamental scaffolds in organic chemistry, particularly due to their prevalence in pharmaceuticals, agrochemicals and materials science.
Catarina M. Correia, Artur M. S. Silva, Vera L. M. Silva   +2 more
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Pyrazoline derivatives as promising novel antischistosomal agents [PDF]

Scientific Reports, 2021
Praziquantel is the only available drug to treat schistosomiasis, a parasitic disease that currently infects more than 240 million people globally. Due to increasing concerns about resistance and inadequate efficacy there is a need for new therapeutics ...
Cristiane S. Morais, Ana C. Mengarda, Fábio B. Miguel, Karine B. Enes, Vinícius C. Rodrigues, Maria Cristina C. Espírito-Santo, Abolghasem Siyadatpanah, Polrat Wilairatana, Mara R. C. Couri, Josué de Moraes   +9 more
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Secosteroid–2-Pyrazoline Hybrids: Design, Synthesis, Biological Evaluation and Development of Therapeutic Combinations Against ERα-Positive Breast Cancer Cells [PDF]

Biomedicines
Background/Objectives: Breast cancer remains one of the most prevalent and life-threatening malignancies worldwide. This study describes the design and biological evaluation of a series of secosteroid–2-pyrazoline hybrids as novel antitumor agents ...
Alexey I. Ilovaisky, Alexander M. Scherbakov, Fedor B. Bogdanov, Dumitru Miciurov, Elena I. Chernoburova, Valentina M. Merkulova, Eugene I. Bozhenko, Andrey S. Dmitrenok, Diana I. Salnikova, Danila V. Sorokin, Alvina I. Khamidullina, Mikhail A. Krasil’nikov, Igor V. Zavarzin, Alexander O. Terent’ev   +13 more
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Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights [PDF]

Drug Design, Development and Therapy, 2022
Tarfah Al-Warhi,1 Ahmed M El Kerdawy,2,3 Mohamed A Said,4 Amgad Albohy,5 Zainab M Elsayed,6 Nada Aljaeed,1 Eslam B Elkaeed,7 Wagdy M Eldehna,8,9 Hatem A Abdel-Aziz,10 Miral A Abdelmoaz11 1Department of Chemistry, College of Science, Princess Nourah Bint ...
Al-Warhi T, El Kerdawy AM, Said MA, Albohy A, Elsayed ZM, Aljaeed N, Elkaeed EB, Eldehna WM, Abdel-Aziz HA, Abdelmoaz MA   +9 more
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Virtual screening of anticancer activity of chalcones and pyrazolines as potential EGFR, VEGFR, and cytochrome P450 inhibitors [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2023
Context: Metastatic breast cancer is still categorized as an incurable disease because all available therapies are palliative treatments to relieve symptoms and increase life expectancy.
Hesti Lina Wiraswati, M. Hasan Bashari, Nayla Majeda Alfarafisa, Ilma Fauziah Ma’ruf, Eti Nurwening Sholikhah, Tutik Dwi Wahyuningsih, Pamungkas Bagus Satriyo, Mustofa, Denny Satria, Ema Damayanti   +9 more
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Expeditious synthesis of 1,3,4-oxadiazole derivatives via sydnones [PDF]

Journal of the Serbian Chemical Society, 2008
The clean cyclization of chalcones (1a–c/2a–c) with hydrazine hydrate under microwave irradiation afforded pyrazolines derivatised with sydnone (3d–i/4d–i), which underwent 1,3-dipolar cyclo-addition with acetic anhydride to form pyrazolines appended ...
D. G. BHADREGOWDA, B. S. SUDHA, RAVINDRA R. KAMBLE   +2 more
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Kallolide A acetate pyrazoline [PDF]

Acta Crystallographica Section E Structure Reports Online, 2011
IN THE CRYSTAL STRUCTURE OF KALLOLIDE A ACETATE PYRAZOLINE [SYSTEMATIC NAME: 7-methyl-16-oxo-4,10-bis-(prop-1-en-2-yl)-17,18-dioxa-14,15-diaza-tetra-cyclo-[9.4.2.1(6,9).0(1,12)]octa-deca-6,8,14-trien-5-yl acetate], C(23)H(28)N(2)O(5), there is a 12-member-ed carbon macrocyclic structure.
Idaliz Rodríguez-Escudero, Jeffrey Marrero, Abimael D. Rodríguez   +2 more
openaire   +3 more sources

Microwave assisted synthesis of some new coumarin-pyrazoline hybrids and their antimicrobial activity [PDF]

Journal of the Serbian Chemical Society, 2015
A series of pyrazolines 4a-g have been synthesized by Michael addition of chalcones 3a-g with hydrazine hydrate in presence of sodium acetate under conventional heating and microwave irradiation.
Ashok Dongamanti, Lakshmi Bommidi Vijaya, Ravi Sidda, Ganesh Arram   +3 more
doaj   +1 more source