Synthesis and Biological Evaluation of Bicyclic Pyrazolines with Promising Antimicrobial Activities. [PDF]
ChemMedChemContinuous flow technology is exploited for the generation of bicyclic pyrazolines via photo‐click reactions. These heterocyclic species contain a valuable 3D scaffold along with a polar succinimide moiety. Subsequent antimicrobial testing reveals that halogenated moieties such as chlorine atoms and trifluoromethoxy groups enhance the potency of these ...
Caviglia D +4 more
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Molecules, 2021 Indoles derived from both natural sources or artificial synthetic methods have been known to interact with aryl hydrocarbon receptors (AhR), and exhibit anticancer activity.
Katharigatta N. Venugopala +3 more
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Pyrazoles and Pyrazolines as Anti-Inflammatory Agents
Molecules, 2021 The five-membered heterocyclic group of pyrazoles/pyrazolines plays important role in drug discovery. Pyrazoles and pyrazolines present a wide range of biological activities.
Martha Mantzanidou +2 more
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Synthesis of novel pyrazoline based bis (1,2,3-triazole) scaffolds via click chemistry [PDF]
Journal of the Serbian Chemical Society, 2017 A series of novel bis(1,2,3-triazoles) derivatives 7a–m were synthesized by the 1,3-dipolar cycloaddition (click-reaction) of 1-methyl-3,5-bis(2- -(prop-2-yn-1-yloxy)phenyl)-4,5-dihydro-1H-pyrazole (5) with various aralkyl azides 6a–m in the presence of ...
Kiran Kothuri +4 more
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Design, synthesis, docking studies and monoamine oxidase inhibition of a small library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1h)-pyrazoles [PDF]
, 2019 New N-acetyl/N-thiocarbamoylpyrazoline derivatives were designed and synthesized in high yields to assess their inhibitory activity and selectivity against human monoamine oxidase A and B.
Carradori, Simone +8 more
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Bulletin of Faculty of Pharmacy Cairo University, 2013 Driven by the increased demand of pyrazolines exhibiting biological activities like antioxidant, anti-inflammatory, antidepressant, antimicrobial, antitumor, and antitubercular drug activity as a stable fragment in biological moieties, lead us to ...
Akshay Kumar +2 more
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Chalcones as versatile synthons for the synthesis of 5- and 6-membered nitrogen heterocylces [PDF]
, 2014 Chalcones belong to the flavonoid family which constitutes one of the major classes of naturally occurring oxygen heterocyclic compounds. The alpha,beta-unsaturated carbonyl system of chalcones possesses two electrophilic reactive centers allowing them ...
Albuquerque, Hélio +3 more
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Synthesis, antimicrobial and antitubercular activities of some novel pyrazoline derivatives
Journal of Saudi Chemical Society, 2016 In the present study, two new series of pyrazolines (3a–h & 4a–h) were synthesized starting from p-acetamidophenol (paracetamol) and evaluated for their antibacterial, antifungal and antitubercular activities.
Aftab Ahmad +4 more
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Synthesis and structure elucidation of novel pyrazolyl-2-pyrazolines obtained by the reaction of 3-(3-aryl-3-oxopropenyl)chromen-4-ones with phenylhydrazine [PDF]
, 2012 Novel 3-aryl-5-{4-[5-(2-hydroxyphenyl)-1-phenylpyrazolyl]}-2-pyrazolines 2a-g have been prepared by the treatment of 3-(3-aryl-3-oxopropenyl)chromen-4-ones 1a-g with phenylhydrazine in refluxing acetic acid. NMR studies on deuteriochloroform solutions of
Jeko, József +3 more
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1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with diazoalkanes [PDF]
, 2010 2-Thio-3-chloroacrylamides undergo 1,3-dipolar cycloadditions with diazoalkanes leading to a series of novel pyrazolines and pyrazoles. The mechanistic and synthetic features of the cycloadditions to the 2-thio-3-chloroacrylamides at both the sulfide and
Kissane, Marie +2 more
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