Results 41 to 50 of about 10,045 (252)
Molecules, 2009 Phenacylmalononitrile 1 reacts with dimethylformamide dimethyl acetal to yield an enaminone which could be readily converted into a pyrrole or an aminopyridazine by treating with ammonium acetate and hydrazine hydrate, respectively.
Mohamed Hilmy Elnagdi +4 more
doaj +1 more source
Synthesis of Pyridazinones via Molecular-Iodine-Mediated Cleavage of 4-Bromomethylcoumarin Precursors [PDF]
, 2016 A facile and an efficient protocol for the synthesis of pyridazinones via molecular-iodine-mediated cleavage of 4-bromomethylcoumarin precursors in the presence of I2 in ethanol at 70 °C is reported.
Devadas Shamala, . +1 more
core +1 more source
Advanced Science, EarlyView.The in situ mass spectrometric identification of the electrogenerated benzylic and phenylic carbocations, whose half‐lives in bulk solutions are on the nanosecond scale, is achieved by taking advantage of the unique stabilization effect of the electrosprayed microdroplets.
Guo‐Shan Zhu, Ren‐Jie Hui, Jun Hu
wiley +1 more source
Synthetic Study of para-Substituted 5,6-Fused Ring Pyridazines [PDF]
, 2010 Much of the focus in organic chemistry today is in area of green chemistry. With such large amounts of attention being paid to how do we create a more sustainable world, the focus has been to come up with new ways to not only create energy but to ...
Mobley, Justin
core +1 more source
ChemistryEurope, EarlyView.Nickel complexes showing reversible vapochromic and spin crossover behaviors upon coordination and release of NH3 were synthesized. They bear bidentate pyridazine ligands, which allows for formation of hydrogen bonds between NH3 and the ligand in the second coordination sphere.
Sebastian Rücker +7 more
wiley +1 more source
Preparation of imidazo[1,2-a]-N-heterocyclic derivatives with gem-difluorinated side chains
Beilstein Journal of Organic Chemistry, 2017 Using an aerobic oxidative coupling, different new imidazo[1,2-a]-N-heterocycles with gem-difluroroalkyl side chains have been prepared in fair yields by the reaction of gem-difluoroenones with aminopyridines, -pyrimidines and -pyridazines.
Layal Hariss +5 more
doaj +1 more source
Журнал органічної та фармацевтичної хімії, 2022 Aim. To analyze and summarize the synthetic potential of 1,2,3-triazole-4(5)-amines as efficient building blocks in the synthesis of triazolo-annulated pyridine, azine and azepine systems. Results and discussion.
Natalia O. Syrota +3 more
doaj +1 more source
Fluorination methods in drug discovery [PDF]
, 2016 Fluorination reactions of medicinal and biologically-active compounds will be discussed. Late stage fluorination strategies of medicinal targets have recently attracted considerable attention on account of the influence that the fluorine atom can impart ...
Bonesi, Sergio Mauricio +2 more
core +1 more source
Selective and Stepwise Functionalization of the Pyridazine Scaffold by Using Thio‐Substituted Pyridazine Building Blocks [PDF]
, 2023 We described a regioselective tri- and tetra-functionalization of the pyridazine scaffold using two readily available building blocks: 3-alkylthio-6-chloropyridazine and 3,4-bis(methylthio)-6-chloropyridazine by performing selective metalations with ...
Brossier, Julie +4 more
core +1 more source
Versatile Palladium‐Catalyzed C‐H Arylation of Fluoroarenes with 2‐Chloropyridine Derivatives
Chemistry – A European Journal, EarlyView.Direct C─H arylation of fluoroarenes with 2‐chloropyridines is enabled by a simple Pd/SPhos system in isopropyl acetate. The method uses inexpensive reactants and shows broad scope and high yields. DFT computations explain reactivity and selectivity.
Federico Belnome +6 more
wiley +1 more source