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Pyridones as Potential Antitumor Agents
Journal of Pharmaceutical Sciences, 1979Based on the finding that 3-acetoxy-2-pyridone had reproducible activity against murine P-388 lymphocytic leukemia, derivatives in this series were synthesized and evaluated to determine structural parameters important for activity. Of the 32 compounds tested, 10 were active.
D R, Hwang, J S, Driscoll
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Ambident Reactivities of Pyridone Anions
Journal of the American Chemical Society, 2010The kinetics of the reactions of the ambident 2- and 4-pyridone anions with benzhydrylium ions (diarylcarbenium ions) and structurally related Michael acceptors have been studied in DMSO, CH(3)CN, and water. No significant changes of the rate constants were found when the counterion was varied (Li(+), K(+), NBu(4)(+)) or the solvent was changed from ...
Martin, Breugst, Herbert, Mayr
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Chemical Physics Letters, 2000
Abstract DFT/B3-LYP(6-31++G**) calculations are used to provide information on closed N – H ⋯ O H -bonded complexes, containing two hydrogen bonds. The studied model systems with two H-bonds are the 2-pyridone dimer, 2-pyridone–H2O and 2-pyridone–CH3OH.
A. Dkhissi +4 more
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Abstract DFT/B3-LYP(6-31++G**) calculations are used to provide information on closed N – H ⋯ O H -bonded complexes, containing two hydrogen bonds. The studied model systems with two H-bonds are the 2-pyridone dimer, 2-pyridone–H2O and 2-pyridone–CH3OH.
A. Dkhissi +4 more
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Pyridone photoelectrocyclizations to pyridophenanthrenes
Tetrahedron, 2017Abstract This article describes the synthesis of pyridophenanthrenes from the stereoselective electrocyclization and [1,5]-hydride shift sequences of biphenyl pyridones. The regioselectivity of the reaction of meta-substituted biphenyl substrates depended on the electronic environment of the substituents.
Xuchen Zhao, Jon D. Rainier
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Synthetic Entries to Substituted Bicyclic Pyridones
Organic Letters, 2007The synthesis of 6,6- and 5,6-bicyclic pyridone scaffolds has been completed using (i) an intramolecular Mitsunobu reaction and/or (ii) hydrolysis of a bicyclic pyridinium salt intermediate. Regioselective functionalization of the pyridone ring has been achieved via either direct lithiation or use of the "halogen dance" reaction.
Cheng, DC +4 more
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Photochemical Reactivity of Pyridones
ChemInform, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
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Journal of the Chemical Society, Perkin Transactions 1, 1988
Lithiation of 1-methyl-2-pyridone takes place mainly at the methyl group which then leads to a dimer (11) by addition to a second mol equivalent of pyridone at C-6. Lithiation of 1-methyl-4-pyridone takes place cleanly and efficiently at C-2; this lithio derivative gave a dimer (13) with a second mol equivalent of the pyridone and reacted with a ...
Premji Meghani, John A. Joule
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Lithiation of 1-methyl-2-pyridone takes place mainly at the methyl group which then leads to a dimer (11) by addition to a second mol equivalent of pyridone at C-6. Lithiation of 1-methyl-4-pyridone takes place cleanly and efficiently at C-2; this lithio derivative gave a dimer (13) with a second mol equivalent of the pyridone and reacted with a ...
Premji Meghani, John A. Joule
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Electroorganic Oxidation of Pyridones
ECS Meeting Abstracts, 2018Electroorganic synthesis can be utilized as a green alternative in complex organic synthesis reactions for pharmaceutical compounds, mitigating or eliminating complex stoichiometric oxidants during organic synthesis. An electrochemical oxidation reaction can make a synthetic transformation more cost effective and more efficient when compared to ...
Dylan Daniel Rodene +4 more
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Chlorosulfonation of 2-pyridones
Chemistry of Heterocyclic Compounds, 1974Chlorosulfonlyl-substituted 2-pyridones were obtained for the first time. The ability of 2-pyridone-3-sulfonyl chlorides to undergo conversion to sulfonylides of the pyridine series by the action of bases is shown in the case of 5,6,7,8-tetrahydro-2-quinolone-3-sulfonyl chloride.
N. P. Shusherina +2 more
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Chemische Berichte, 1960
AbstractAus α‐Pyridon‐silber und 1.3‐Dijod‐propan wurde 2.3‐Dihydro‐4H‐pyrid[2.1‐b]‐oxaziniumjodid erhalten. Aus 1‐Diazo‐3‐chlor‐aceton und α‐Pyridon ließen sich 1.3‐Bis‐[2‐oxo‐1.2‐dihydro‐pyridyl‐(1)]‐aceton und N‐[3‐Chlor‐acetonyl]‐α‐pyridon gewinnen. Deren katalyt. Hydrierung führte zu den entspr.
Karl Winterfeld, Helmut Michael
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AbstractAus α‐Pyridon‐silber und 1.3‐Dijod‐propan wurde 2.3‐Dihydro‐4H‐pyrid[2.1‐b]‐oxaziniumjodid erhalten. Aus 1‐Diazo‐3‐chlor‐aceton und α‐Pyridon ließen sich 1.3‐Bis‐[2‐oxo‐1.2‐dihydro‐pyridyl‐(1)]‐aceton und N‐[3‐Chlor‐acetonyl]‐α‐pyridon gewinnen. Deren katalyt. Hydrierung führte zu den entspr.
Karl Winterfeld, Helmut Michael
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