Whole blood NAD and NADP concentrations are not depressed in subjects with clinical pellagra [PDF]
, 2007 Population surveys for niacin deficiency are normally based on clinical signs or on biochemical measurements of urinary niacin metabolites. Status may also be determined by measurement of whole blood NAD and NADP concentrations. To compare these methods,
Cheung, E +5 more
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Recent Progress in Nitro-Promoted Direct Functionalization of Pyridones and Quinolones
Molecules, 2020 Nitro group is one of the most important functional groups in organic syntheses because its strongly electron-withdrawing ability activates the scaffold, facilitating the reaction with nucleophilic reagents or the Diels−Alder reaction.
Feiyue Hao, Nagatoshi Nishiwaki
doaj +1 more source
A novel non-peptidic agonist of the ghrelin receptor with orexigenic activity in vivo [PDF]
, 2016 Loss of appetite in the medically ill and ageing populations is a major health problem and a significant symptom in cachexia syndromes, which is the loss of muscle and fat mass. Ghrelin is a gut-derived hormone which can stimulate appetite.
Clarke, Sarah L. +7 more
core +3 more sources
The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one
Molecules, 2003 3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4 ...
Masahiro Ariga +4 more
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Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106 [PDF]
, 2014 Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas.
Bin Wu +9 more
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Characterization studies of 1-(4-cyano-2-oxo-1,2-dihydro-1-pyridyl)-3-(4-cyano-1,2-dihydro-1-pyridyl)propane formed from the reaction of hydroxide Ion with 1,3-Bis-(4-cyano pyridinium)propane [PDF]
, 2011 The aqueous alkaline reaction of 1,3-bis(4-cyanopyridinium)propane dibromide, a reactant constituted of two pyridinium rings linked by a three-methylene bridge, generates a novel compound,1 -(4-cyano-2-oxo-1,2-dihydro-1-pyridyl)-3-(4-cyano-1,2-dihydro-1 ...
CATALANI, Luiz H +7 more
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Molecules, 2017 A new N-methoxypyridone analog (1), together with four known compounds, was isolated from the co-culture of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062.
Chunshun Li +4 more
doaj +1 more source
Toxins, 2011 We have identified a novel nucleotide, 4-pyridone 3/5-carboxamide ribonucleoside triphosphate (4PyTP), which accumulates in human erythrocytes during renal failure.
Elizabeth A. Carrey +5 more
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A ‘bottom up’, ab initio computational approach to understanding fundamental photophysical processes in nitrogen containing heterocycles, DNA bases and base pairs [PDF]
, 2016 A systematic computational study of non-radiative decay pathways following UV excitation of selected heterocycles, DNA bases, nucleosides and base-pairs in the gas phase.
Ashfold, Michael N R +3 more
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Ligand-guided homology modeling drives identification of novel histamine H3 receptor ligands [PDF]
, 2019 In this study, we report a ligand-guided homology modeling approach allowing the analysis of relevant binding site residue conformations and the identification of two novel histamine H3 receptor ligands with binding affinity in the nanomolar range.
Hagenow, Stefanie +3 more
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