Synthesis of New Aza-Heterocyclic Based on 2-Pyridone
Chemistry ProceedingsIn this work, we present new methods of synthesis of different molecules including a 2-pyridone nucleus. First, we prepared a series of 1H-free 2-pyridones and N-alkyl 2-pyridones from ethyl cyanoacetate, aromatic aldehydes, various acetophenone ...
Ikram Baba-Ahmed +4 more
doaj +1 more source
Potential role of PIM1 inhibition in the treatment of SARS-CoV-2 infection
Journal of Genetic Engineering and Biotechnology, 2023 Background SARS-CoV-2 infection involves disturbing multiple molecular pathways related to immunity and cellular functions. PIM1 is a serine/threonine-protein kinase found to be involved in the pathogenesis of several viral infections. One PIM1 substrate,
Magda M. F. Ismail +8 more
doaj +1 more source
Die Acylierung von 4‐Pyridon [PDF]
Chemische Berichte, 1980 AbstractBei der Acylierung von 4‐Pyridon (1) mit aliphatischen Carbonsäure‐anhydriden und ‐chloriden oder freien Säuren in Gegenwart von Dicyclohexylcarbodiimid erhält man ausschließlich N‐Acyl‐4‐pyridone (5). Auch bei der Umsetzung von 1 mit ortho‐substituierten Benzoesäurederivaten sind nur N‐Acylierungsprodukte 8 isolierbar.
Effenberger, Franz +2 more
openaire +1 more source
A study of the effects of exercise on the urinary metabolome using normalisation to individual metabolic output [PDF]
, 2015 Aerobic exercise, in spite of its multi-organ benefit and potent effect on the metabolome, has yet to be investigated comprehensively via an untargeted metabolomics technology.
Anthony, Nahoum +5 more
core +2 more sources
Continuous flow synthesis of some 6- and 1,6-substituted 3-cyano-4-methyl-2-pyridones [PDF]
Journal of the Serbian Chemical Society, 2019 In this study, six 6- and 1,6-substituted-3-cyano-4-methyl-2-pyridones were synthesized in a continuous flow microreactor system. The syntheses were realized at room temperature and the obtained results were compared to those achieved within classical ...
Tadić Julijana +3 more
doaj +1 more source
Switching the Conductance of a Molecular Junction using a Proton Transfer Reaction
, 2014 A novel mechanism for switching a molecular junction based on a proton transfer reaction triggered by an external electrostatic field is proposed.
Coto, P. B. +5 more
core +1 more source
Solution Equilibrium Studies on Anticancer Ruthenium(II)–eta6-p-cymene Complexes of 3-Hydroxy-2(1H)-pyridones [PDF]
, 2013 Ru-II(eta(6)-p-cymene) complexes of bidentate (0,0) alkoxycarbonylmethyl-3-hydroxy-2(1H)-pyridone ligands exhibit in vitro antitumor activity. We determined the stoichiometry and stability in aqueous solution of two examples by pH-potentiometry, H-1 NMR ...
Bognár, Gabriella M. +4 more
core +1 more source
Synthesis of 5-(substituted phenylazo)-6-hydroxy-4-methyl-3-cyano-2-pyridones from ethyl 3-oxo-2-(substituted phenylazo)butanoates, Short communication [PDF]
Journal of the Serbian Chemical Society, 2011 A new procedure for the synthesis of known azo pyridone dyes is presented. A series of 5-(substituted arylazo)-6-hydroxy-4-methyl-3-cyano-2-pyridones were prepared from ethyl 3-oxo-2-(substituted phenylazo)butanoates and cyanoacetamide in acetone using ...
GORDANA UŠĆUMLIĆ +3 more
doaj
Rhodium(I)-Complexes Catalyzed 1,4-Conjugate Addition of Arylzinc Chlorides to N-Boc-4-pyridone
Molecules, 2017 Rhodium(I)-complexes catalyzed the 1,4-conjugate addition of arylzinc chlorides to N-Boc-4-pyridone in the presence of chlorotrimethylsilane (TMSCl). A combination of [RhCl(C2H4)2]2 and BINAP was determined to be the most effective catalyst to promote ...
Fenghai Guo +5 more
doaj +1 more source
Heterocyclic Communications, 2022 2-Pyridone is considered as one of the most famous efficient pharmaceutical compounds. Many approaches were discovered to synthesize 2-pyridone. In this present research, chloroacetylation of benzylamine at simple conditions, EtONa/EtCOONa produced N ...
Hamed Eman O. +4 more
doaj +1 more source