Results 61 to 70 of about 12,861 (208)

Comparative evaluation of noncanonical amino acids as site‐specific NMR probes for the complex of E. coli SSB with single‐stranded DNA without isotope labelling

The FEBS Journal, EarlyView.
Genetic encoding of noncanonical amino acids (ncAA) enables their site‐specific installation in proteins. This work compares the nuclear magnetic resonance (NMR) performance of different ncAAs in a large protein−DNA complex (~ 100 kDa) without isotope labelling. The ncAAs deliver readily detectable NMR signals in the complex between E.
Sreelakshmi Mekkattu Tharayil, Haocheng Qianzhu, Elwy H. Abdelkader, Adarshi P. Welegedara, Josemon George, Christoph Nitsche, Thomas Huber, Gottfried Otting   +7 more
wiley   +1 more source

Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death [PDF]

, 2009
Multitarget compounds that act on a diverse set of regulatory pathways are emerging as a therapeutic approach for a variety of cancers. Toward a more specified use of this approach, we hypothesize that the desired efficacy can be recreated in terms of a ...
Cosgrove, Benjamin D., Griffith, Linda G, Hemann, Michael, Lauffenburger, Douglas A, Pritchard, Justin R., Wands, Jack R.   +5 more
core   +1 more source

5,5’-Selenobis(1-benzyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde)

Molbank
Selenium compounds have garnered significant attention in the field of medicinal chemistry due to their unique biochemical properties and potential therapeutic applications for different pathologies.
Emeline Grosjean, Julien Rizet, Shekoufeh Arabi Aliabadi, Joelle Azéma-Despeyroux, Pascal Hoffmann, Christian Lherbet   +5 more
doaj   +1 more source

Crystal structure of N-[6-amino-5-(benzo[d]thiazol-2-yl)-3-cyano-4-methylsulfanyl-2-oxo-1,2-dihydropyridin-1-yl]-4-methylbenzenesulfonamide dimethylformamide monosolvate

Acta Crystallographica Section E: Crystallographic Communications, 2017
In the title compound, C21H17N5O3S3·C3H7NO, the toluenesulfonamide ring and the combined ring system involving the pyridone and benzothiazole rings subtend an interplanar angle of 39.86 (4)°.
Rasha A. Azzam, Galal H. Elgemeie, Rasha E. Elsayed, Peter G. Jones   +3 more
doaj   +1 more source

Asymmetric Negishi and Kumada Couplings

Advanced Synthesis &Catalysis, Volume 368, Issue 5, 3 March 2026.
This review summarizes asymmetric Negishi and Kumada cross‐coupling reactions from the 1980s through 2025. It examines enantioselective and enantiospecific transformations catalyzed by nickel, palladium, and cobalt complexes , highlighting ligand design, mechanistic insights, and applications in constructing complex chiral molecules and natural ...
Rui‐Heng Wang, Aishun Ding, Ramon Rios
wiley   +1 more source

Frame‐Shifted Synthesis of Oligoheterocycles as a Platform for Molecular Design

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Modern chemistry seeks to turn the simple raw materials into complex molecules that matter in health, agriculture, and technology. Among these, oligoheterocycles stand out for their versatility, yet they are most often built by cross‐coupling reactions that often rely on expensive metal catalysts.
Kane A. C. Bastick, Caleb E. Griesbach, Ben Zhen Huang, Morgan J. Cordell, Yang (Daniel) Ou, Alán Aspuru‐Guzik, Andrei K. Yudin   +6 more
wiley   +2 more sources

Dinuclear Rhodium(I)–N‐Heterocyclic Carbene Complexes as Alkyne Hydropyridonation Catalysts

European Journal of Inorganic Chemistry, Volume 29, Issue 7, 2 March 2026.
Catalyst Improvement by NHC tuning: A series of new RhI–NHC dinuclear complexes has been revealed as efficient alkyne hydropyridonation catalysts. 333053IMes complex displays the highest reactivity of the series, suggesting that a moderate steric demand combined with balanced σ‐donation facilitates precatalyst activation and substrate exchange.
Belinda Español‐Sánchez, Mert Olgun Karataş, Andrea Di Giuseppe, Ulugbek Togaev, Vincenzo Passarelli, Luis A. Oro, Jesús J. Pérez‐Torrente, Ricardo Castarlenas   +7 more
wiley   +1 more source

catena-Poly[[[(2-pyridone-κO)silver(I)]-μ-2-pyridone-κ2O:O] hexafluoridophosphate]

Acta Crystallographica Section E, 2010
The asymmetric unit of the polymeric title salt, {[Ag(C5H5NO)2]PF6}n, comprises an AgI cation (located on a twofold axis), two 2-pyridone ligands (with distinct coordination modes), and half a PF6− anion (situated on a centre of inversion). The
Edward R. T. Tiekink, Tyler Miller, Hadi D. Arman   +2 more
doaj   +1 more source

Synthesis of tetranuclear rhodium and iridium complexes directed by 6-mercaptopyridin-2-ol: Electrochemical behavior, chemical oxidation, and coordination chemistry [PDF]

, 2016
The new ligand 6-mercapto-2(1 H)-pyridone (H2PySO) has been prepared in good yield by reaction of 6-chloro-pyridin-2-ol with NaSH. Reaction of the salt K2PySO, generated in situ, with the appropriate complex [M(μ-C1)(diolefin)]2affords the tetranuclear ...
Alonso, Pablo J., Benedí, Oscar, Fabra-Caro, María J., Lahoz, Fernando J., Oro, Luis A., Pérez-Torrente, Jesús J.   +5 more
core   +2 more sources

1-[(2-Chloro-7,8-dimethylquinolin-3-yl)methyl]pyridin-2(1H)-one

Acta Crystallographica Section E, 2010
In the title compound, C17H15ClN2O, the quinoline ring system is nearly planar, with a maximum deviation from the mean plane of 0.074 (2) Å, and makes a dihedral angle of 81.03 (7)° with the pyridone ring ...
F. Nawaz Khan, S. Mohana Roopan, Venkatesha R. Hathwar, Mehmet Akkurt   +3 more
doaj   +1 more source