Molecules, 2012 Pirfenidone, a pyridone compound, is an effective and novel antifibrotic agent. In this article, we describe the design, synthesis and activity evaluation of novel antifibrotic agents, 1-(substituted aryl)-5-trifluoromethyl-2(1H) pyridones modified with ...
Lijian Tao +9 more
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New functionalisation chemistry of 2- and 4-pyridones and related heterocycles [PDF]
, 2016 New methodology for the synthesis of several 4H-pyrido[1,2-a]pyrimidin-4-ones has been developed from commercially available 2-aminopyridines and β-oxo esters catalysed by Montmorillonite under solvent-free conditions in good yields. This methodology was
Beatriz Fernandez (5781758)
core
Addition of dianions of carboxylic acids to imines. Influence of the acid in the outcome of the reaction [PDF]
, 2009 The addition of different carboxylic acids dianions to N-benzylidenebenzeneamine have been studied. The outcome of the reaction depends on the acid. Saturated ones lead to β-aminoacids with good yields and syn-selectivity whereas α,β-unsaturated ones ...
Gil Grau, Salvador +2 more
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Synthesis and Cyclizations of N-(2,3-, 3,4- and 3,5-Dimethylphenyl)-β-alanines
Molecules, 2005 A series of 1-aryl substituted dihydro-, 5-methyldihydro- and 6-methyl-dihydro-2,4(1H,3H)pyrimidinediones and their 2-thio analogues were obtained byreaction of the corresponding β-alanines or α-methyl- and β-methyl-β-alanines with ureaor ...
Gema Mikulskiene +2 more
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Structural and functional characterization of Pseudomonas aeruginosa CupB chaperones [PDF]
, 2010 Pseudomonas aeruginosa, an important human pathogen, is estimated to be responsible for,10% of nosocomial infections worldwide. The pathogenesis of P. aeruginosa starts from its colonization in the damaged tissue or medical devices (e. g.
A Filloux +40 more
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Synthesis of 5-(substituted phenylazo)-6-hydroxy-4-methyl-3-cyano-2-pyridones from ethyl 3-oxo-2-(substituted phenylazo)butanoates, Short communication [PDF]
Journal of the Serbian Chemical Society, 2011 A new procedure for the synthesis of known azo pyridone dyes is presented. A series of 5-(substituted arylazo)-6-hydroxy-4-methyl-3-cyano-2-pyridones were prepared from ethyl 3-oxo-2-(substituted phenylazo)butanoates and cyanoacetamide in acetone using ...
GORDANA UŠĆUMLIĆ +3 more
doaj
Molecules, 2004 The reaction of 4-hydroxycoumarin (1) with some primary amines 2a-h and morpholine (2i) under microwave irradiation occurred without opening of the lactone ring to give N-substituted 4-aminocoumarins 3a-i in excellent yields.
Ivo C. Ivanov, Edmont V. Stoyanov
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Triacetic acid lactone as a common intermediate for the synthesis of 4-hydroxy-2-pyridones and 4-amino-2-pyrones [PDF]
, 2015 At ambient temperature, triacetic acid lactone reacts with amines to produce 4-amino-2-pyrones.
Bottoms, Jashaun +3 more
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THE PROPERTIES OF n‐PROPYL 3:5‐DI‐IODO‐4‐PYRIDONE‐N‐ACETATE (PROPYLIODONE) [PDF]
, 1953 E. G. TOMICH, B. BASIL, Benjamin Davis
openalex +1 more source
Dakin-West Trick in the Design of Novel 2-Alkyl(aralkyl) Derivatives of Oxazolo[3,2-a]pyridines
Molecules, 2005 A series of previously unavailable derivatives of 2-alkyl- and 2-benzylderivatives of oxazolo[3,2-a]pyridines III were obtained via tandem ring opening and ring closure from stable mesoionic 3-acyloxazolo[3,2-a]pyridinium-2-olates I.
Eugene V. Babaev +2 more
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