Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106 [PDF]
Marine Drugs, 2014 Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas.
Bin Wu +4 more
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mBio, 2021 Diverse 2-pyridone alkaloids have been identified with an array of biological and pharmaceutical activities, including the development of drugs. However, the biosynthetic regulation and chemical ecology of 2-pyridones remain largely elusive.
Bo Chen +4 more
doaj +1 more source
Molecules, 2023 This work describes the synthesis of 3-hydroxy-3,4-dihydropyrido[2,1-c][1,4]oxazine-1,8-diones, their tautomerism, and reactivity towards binucleophiles. These molecules are novel and convenient building-blocks for the direct construction of biologically
Viktoria V. Viktorova +3 more
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Reactions of 2-methylchromones with cyanoacetamides and ethyl cyanoacetate. synthesis of 6-(2-hydroxyaryl)-4-methyl-2-oxo-1,2-dihydropyridine-3- carbonitriles and 7-hydroxy-6-imino-9-methyl-6h-benzo[c]chromene-8-carbonitriles [PDF]
, 2013 Although 2-methylchromones react with cyanoacetamide and N-methyl cyanoacetamide in the presence of sodium ethoxide in refluxing ethanol to produce 6-(2-hydroxyaryl)-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitriles, their reactions with ethyl ...
Al Naimi +23 more
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Acta Crystallographica Section E Structure Reports Online, 2011 The crystal structure of the title compound, C(6)H(7)NO, is stabilized by inter-molecular N-H⋯O hydrogen bonds, resulting in inversion dimers. The structure is further consolidated by weak C-H⋯O hydrogen bonds.
Shulin Mao, Luo Yanghui, Pan Meiling
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2-Pyridone: monoclinic polymorph [PDF]
Acta Crystallographica Section E Structure Reports Online, 2009 تتكون الوحدة غير المتماثلة في مركب العنوان، C(5)H(5)NO، من جزيئتين مستقلتين ولكن متطابقتين تقريبًا من 2 -بيريدون، وتمثل شكلًا متعددًا أحادي الميل من شكل أورثو- روم- بيك (P2 (1)2(1)2(1)) [Penfold (1953▶). أكتا كريست .6، 591-600 ؛ أومس وآخرون. (1984▶). Z. Kristallogr.169، 185-200 ؛ Yang & Craven (1998▶). أكتا كريست. B54، 912-920]. ترتبط الحبيبات الجزيئية
Hadi D. Arman +2 more
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13C- and 1H-NMR substituent-induced chemical shifts in N(1)-(4-substituted phenyl)-3-cyano-4,6-dimethyl-2-pyridones [PDF]
Journal of the Serbian Chemical Society, 2008 The 13C- and 1H-NMR chemical shifts of thirteen N(1)-(4-substituted phenyl)-3-cyano-4,6-dimethyl-2-pyridones were measured in deuterated dimethyl sulfoxide (DMSO-d6). The correlation analysis for the substituent-induced chemical shifts (SCS) with sigmap,
BRATISLAV Z. JOVANOVIC +4 more
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A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis. [PDF]
, 2014 UnlabelledIn a screen for compounds that inhibit infectivity of the obligate intracellular pathogen Chlamydia trachomatis, we identified the 2-pyridone amide KSK120.
Almqvist, Fredrik +12 more
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A novel non-peptidic agonist of the ghrelin receptor with orexigenic activity in vivo [PDF]
, 2016 Loss of appetite in the medically ill and ageing populations is a major health problem and a significant symptom in cachexia syndromes, which is the loss of muscle and fat mass. Ghrelin is a gut-derived hormone which can stimulate appetite.
Clarke, Sarah L. +7 more
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Quinolones modulate ghrelin receptor signaling: potential for a novel small molecule scaffold in the treatment of cachexia [PDF]
, 2018 Cachexia is a metabolic wasting disorder characterized by progressive weight loss, muscle atrophy, fatigue, weakness, and appetite loss. Cachexia is associated with almost all major chronic illnesses including cancer, heart failure, obstructive ...
Cano, Rafael +8 more
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