Recent Progresses in the Catalytic Stereoselective Dearomatization of Pyridines [PDF]
Molecules, 2023 1,2- and 1,4-dihydropyridines and N-substituted 2-pyridones are very important structural motifs due to their synthetic versatility and vast presence in a variety of alkaloids and bioactive molecules.
Lucrezia Margherita Comparini +1 more
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Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106 [PDF]
Marine Drugs, 2014 Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas.
Bin Wu +4 more
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2-Bromopyridines as Versatile Synthons for Heteroarylated 2-Pyridones via Ru(II)-Mediated Domino C–O/C–N/C–C Bond Formation Reactions [PDF]
MoleculesA novel methodology for the synthesis of 2-pyridones bearing a 2-pyridyl group on nitrogen and carbon atoms, starting from 2-bromopyridines, was developed employing a simple Ru(II)–KOPiv–Na2CO3 catalytic system.
Miha Drev +6 more
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Microwave assisted synthesis of 2-pyridone and 2-pyridone based compounds [PDF]
Hemijska Industrija, 2014 2-Pyridones are important heterocyclic compounds that are widely used in medical chemistry, and their various derivatives have significant biological and medical applications.
Mijin Dušan Ž. +3 more
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A Highly Substituted Ring-Fused 2-Pyridone Compound Targeting PrfA and the Efflux Regulator BrtA in Listeria monocytogenes [PDF]
mBio, 2023 Listeria monocytogenes is a facultative Gram-positive bacterium that causes listeriosis, a severe foodborne disease. We previously discovered that ring-fused 2-pyridone compounds can decrease virulence factor expression in Listeria by binding and ...
Hasan Tükenmez +10 more
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Metal-Free Cascade Formation of C–C and C–N Bond for the Construction of 3-Cyano-2-Pyridones with Insecticidal Properties [PDF]
MoleculesA straightforward and efficient methodology has been developed for the synthesis of 3-cyano-2-pyridones via the C–C and C–N bond formation processes. A total of 51 diverse 3-cyano-2-pyridone derivatives were obtained in moderate to excellent yields. This
Yao Tang +5 more
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Photochemical Cycloadditions to 5,6-Dihydro-4-pyridones [PDF]
CHIMIA, 1987 5,6-Dihydro-4-pyridones (3a-3c) undergo photochemical [2 + 2]-cycloaddition with olefins activated by an electron withdrawing group. Alkyl substituted double bonds could only be brought to react in the intramolecular cases 3d and 3e.
Philippe Guerry, Reinhard Neier
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The Biochemical Pathways of Nicotinamide-Derived Pyridones [PDF]
International Journal of Molecular Sciences, 2021 As catabolites of nicotinamide possess physiological relevance, pyridones are often included in metabolomics measurements and associated with pathological outcomes in acute kidney injury (AKI). Pyridones are oxidation products of nicotinamide, its methylated form, and its ribosylated form.
Faisal Hayat +2 more
exaly +6 more sources
Diversity-oriented functionalization of 2-pyridones and uracils
Nature Communications, 2021 Diversity-oriented synthesis of 2-pyridone and uracil derivatives is in urgent need in medicinal chemistry as they are useful pharmacophores. Here the authors show that palladium/norbornene cooperative catalysis enabled dual-functionalization of ...
Hong-gang Cheng +2 more
exaly +2 more sources
A microwave approach to the synthesis of certain 4-substituted phenyl-6-phenyl-3-cyano-2-pyridones [PDF]
Journal of the Serbian Chemical Society, 2014 A study of the synthesis of 4-substituted phenyl-6-phenyl-3-cyano-2-pyridones from 2-cyano-3-phenylsubstituted acrylates and acetophenone is presented. 2-Pyridones were obtained using conventional as well as microwave synthesis using solvent and
Marinković Aleksandar +4 more
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