Reactions of 2-methylchromones with cyanoacetamides and ethyl cyanoacetate. synthesis of 6-(2-hydroxyaryl)-4-methyl-2-oxo-1,2-dihydropyridine-3- carbonitriles and 7-hydroxy-6-imino-9-methyl-6h-benzo[c]chromene-8-carbonitriles [PDF]
, 2013 Although 2-methylchromones react with cyanoacetamide and N-methyl cyanoacetamide in the presence of sodium ethoxide in refluxing ethanol to produce 6-(2-hydroxyaryl)-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitriles, their reactions with ethyl ...
Al Naimi +23 more
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Molecules, 2023 This work describes the synthesis of 3-hydroxy-3,4-dihydropyrido[2,1-c][1,4]oxazine-1,8-diones, their tautomerism, and reactivity towards binucleophiles. These molecules are novel and convenient building-blocks for the direct construction of biologically
Viktoria V. Viktorova +3 more
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Acta Crystallographica Section E Structure Reports Online, 2011 The crystal structure of the title compound, C(6)H(7)NO, is stabilized by inter-molecular N-H⋯O hydrogen bonds, resulting in inversion dimers. The structure is further consolidated by weak C-H⋯O hydrogen bonds.
Shulin Mao, Luo Yanghui, Pan Meiling
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2-Pyridone: monoclinic polymorph [PDF]
Acta Crystallographica Section E Structure Reports Online, 2009 تتكون الوحدة غير المتماثلة في مركب العنوان، C(5)H(5)NO، من جزيئتين مستقلتين ولكن متطابقتين تقريبًا من 2 -بيريدون، وتمثل شكلًا متعددًا أحادي الميل من شكل أورثو- روم- بيك (P2 (1)2(1)2(1)) [Penfold (1953▶). أكتا كريست .6، 591-600 ؛ أومس وآخرون. (1984▶). Z. Kristallogr.169، 185-200 ؛ Yang & Craven (1998▶). أكتا كريست. B54، 912-920]. ترتبط الحبيبات الجزيئية
Hadi D. Arman +2 more
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13C- and 1H-NMR substituent-induced chemical shifts in N(1)-(4-substituted phenyl)-3-cyano-4,6-dimethyl-2-pyridones [PDF]
Journal of the Serbian Chemical Society, 2008 The 13C- and 1H-NMR chemical shifts of thirteen N(1)-(4-substituted phenyl)-3-cyano-4,6-dimethyl-2-pyridones were measured in deuterated dimethyl sulfoxide (DMSO-d6). The correlation analysis for the substituent-induced chemical shifts (SCS) with sigmap,
BRATISLAV Z. JOVANOVIC +4 more
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A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis. [PDF]
, 2014 UnlabelledIn a screen for compounds that inhibit infectivity of the obligate intracellular pathogen Chlamydia trachomatis, we identified the 2-pyridone amide KSK120.
Almqvist, Fredrik +12 more
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A novel non-peptidic agonist of the ghrelin receptor with orexigenic activity in vivo [PDF]
, 2016 Loss of appetite in the medically ill and ageing populations is a major health problem and a significant symptom in cachexia syndromes, which is the loss of muscle and fat mass. Ghrelin is a gut-derived hormone which can stimulate appetite.
Clarke, Sarah L. +7 more
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Organic Letters, 2021 A rhodium-catalyzed C4-selective C-H alkenylation of 3-carboxy-2-pyridones with styrenes has been developed. The carboxylic group at the C3 position works as the traceless directing group, and the corresponding C4-alkenylated 2-pyridones are obtained ...
Sunit Hazra, K. Hirano, M. Miura
semanticscholar +1 more source
Efficient synthesis of novel thieno[3,2-b]-, [2,3-c]- and [3,2-c]pyridones by Sonogashira coupling of bromothiophenes with terminal alkynes and subsequent intramolecular C-N bond-forming reaction [PDF]
, 2013 The coupling of bromothiophenes with terminal alkynes using triethylamine or diisopropyl amine under Sonogashira conditions (PdCl2(PPh 3)2, CuI) followed by subsequent addition of amines or ammonium to the intermediate thienyl acetylenes represents a ...
Abbasi, M. S. A. +7 more
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3-Cyano-4,6-dimethyl-2-pyridone (Guareschi pyridone)
Acta Crystallographica Section E Structure Reports Online, 2004 In the crystal structure of the title compound, C8H8N2O, the molecules form centrosymmetric dimers via N—H⋯O hydrogen bonds.
Victor B. Rybakov +3 more
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