Results 21 to 30 of about 11,107 (336)

Culturing of Giardia lamblia under microaerobic conditions can impact metronidazole susceptibility by inducing increased expression of antioxidant enzymes [PDF]

International Journal for Parasitology: Drugs and Drug Resistance
The microaerophilic/anaerobic protist Giardia lamblia is a world-wide occurring parasite of the human small intestine. It causes giardiasis which manifests as diarrhoea accompanied by other sequelae.
Kateryna Starynets, Ana Paunkov, Anja Wagner, Klaus Kratochwill, Christian Klotz, David Leitsch   +5 more
doaj   +2 more sources

Association between Moraxella keratitis and advanced glycation end products [PDF]

Scientific Reports
Diabetes mellitus is recognized as a major predisposing factor for Moraxella keratitis. However, how diabetes mellitus contributes to Moraxella keratitis remains unclear.
Hidenori Inoue, Koji Toriyama, Naoko Takahira, Shinobu Murakami, Hitoshi Miyamoto, Takashi Suzuki, Atsushi Shiraishi   +6 more
doaj   +2 more sources

Effect of miR-27b-3p and Nrf2 in human retinal pigment epithelial cell induced by high-glucose [PDF]

International Journal of Ophthalmology, 2023
AIM: To determine whether the microRNA-27b-3p (miR-27b-3p)/NF-E2-related factor 2 (Nrf2) pathway plays a role in human retinal pigment epithelial (hRPE) cell response to high glucose, how miR-27b-3p and Nrf2 expression are regulated, and whether this ...
Qiao-Ling Lai, Ting Xie, Wei-Dong Zheng, Yan Huang   +3 more
doaj   +1 more source

Pyridoxamine reduces methylglyoxal and markers of glycation and endothelial dysfunction, but does not improve insulin sensitivity or vascular function in abdominally obese individuals: A randomized double‐blind placebo‐controlled trial

Diabetes, obesity and metabolism, 2023
To investigate the effects of pyridoxamine (PM), a B6 vitamer and dicarbonyl scavenger, on glycation and a large panel of metabolic and vascular measurements in a randomized double‐blind placebo‐controlled trial in abdominally obese individuals.
M. D. Van den Eynde, A. Houben, J. Scheijen, A. Linkens, P. Niessen, N. Simons, N. Hanssen, Y. Kusters, S. Eussen, T. Miyata, C. Stehouwer, C. Schalkwijk   +11 more
semanticscholar   +1 more source

Pyridoxamine and Aminoguanidine Attenuate the Abnormal Aggregation of β-Tubulin and Suppression of Neurite Outgrowth by Glyceraldehyde-Derived Toxic Advanced Glycation End-Products

Frontiers in Pharmacology, 2022
Diabetes mellitus (DM) has been identified as a risk factor for the onset and progression of Alzheimer’s disease (AD). In our previous study, we demonstrated that glyceraldehyde (GA)-derived toxic advanced glycation end-products (toxic AGEs, TAGE ...
Hayahide Ooi, Ryuto Nasu, A. Furukawa, M. Takeuchi, Y. Koriyama   +4 more
semanticscholar   +1 more source

Pyridoxamine treatment ameliorates large artery stiffening and cerebral artery endothelial dysfunction in old mice

Journal of Cerebral Blood Flow and Metabolism, 2022
Age-related increases in large artery stiffness are associated with cerebrovascular dysfunction and cognitive impairment. Pyridoxamine treatment prevents large artery stiffening with advancing age, but the effects of pyridoxamine treatment on the ...
Emily H. Reeve, Elise K. Kronquist, Julia R Wolf, Byron Lee, Aleena Khurana, Hanson Pham, Abigail E. Cullen, Jessica A. Peterson, Antonio Meza, R. Colton Bramwell, L. Villasana, Daniel R. Machin, Grant D. Henson, Ashley E. Walker   +13 more
semanticscholar   +1 more source

Scientific opinion on the tolerable upper intake level for vitamin B6

EFSA Journal, 2023
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on the tolerable upper intake level (UL) for vitamin B6.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan deHenauw, Karen‐Ildico Hirsch‐Ernst, Helle Katrine Knutsen, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Susan Fairweather‐Tait, Misha Vrolijk, Lucia Fabiani, Ariane Titz, Androniki Naska   +20 more
doaj   +1 more source

Pyridoxamine ameliorates methylglyoxal‐induced macrophage dysfunction to facilitate tissue repair in diabetic wounds

International Wound Journal, 2021
Methylglyoxal (MGO) is a highly reactive dicarbonyl compound formed during hyperglycaemia. MGO combines with proteins to form advanced glycation end products (AGEs), leading to cellular dysfunction and organ damage.
Minfei Jiang, Aobuliaximu Yakupu, H. Guan, Jiaoyun Dong, Yingkai Liu, F. Song, Jiajun Tang, M. Tian, Y. Niu, Shuliang Lu   +9 more
semanticscholar   +1 more source

B6 vitamers as generators and scavengers of reactive oxygen species

Journal of Photochemistry and Photobiology, 2021
B6 vitamers are important natural compounds for human life, principally for amino acid metabolism, and have been reported as potent scavenger molecules of both endogenous and exogenous reactive oxygen species (ROS).
Italo Rodrigo Calori, Luiza Araújo Gusmão, Antonio Claudio Tedesco   +2 more
doaj   +1 more source

Synthesis of B6 vitamin [PDF]

Hemijska Industrija, 2009
The importance of vitamin B6 has been known since its discovery in the 1940's. Chemical tests, elestrometric titration determinations, and absorption spectrum studies showed that this vitamin exists in three major chemical forms: pyridoxine (an alcohol),
Vučijak Nevena Ž., Petrović Slobodan D., Bezbradica Dejan I., Knežević-Jugović Zorica D., Mijin Dušan Ž.   +4 more
doaj   +1 more source