Results 11 to 20 of about 5,110,049 (220)

Urinary excretion of tryptophan, lysine, trimethyllysine, sarcosine, choline and 4-pyridoxic acid in urolithiasis

Experimental and Сlinical Urology, 2022
Introduction. The role of the organic matrix in urinary stones genesis in urolithiasis patients is still unclear. The presence of a large amount of protein in the urinary stones matrix suggests the participation of the protein matrix in lithogenesis ...
С.А. Голованов, V.N. Sinyukhin, Vadim N. Tashlitsky, А.В. Сивков, M.Yu. Prosyannikov, N.V. Anokhin, D.A. Voytko, V.V. Drozhzheva, D.A. Eremeeva, О.И. Аполихин, А. Д. Каприн, A.D. Kaprin   +11 more
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Development of 4‐Pyridoxic Acid PBPK Model to Support Biomarker‐Informed Evaluation of OAT1/3 Inhibition and Effect of Chronic Kidney Disease [PDF]

Clinical pharmacology and therapy, 2023
Monitoring endogenous biomarkers is increasingly used to evaluate transporter‐mediated drug–drug interactions (DDIs) in early drug development and may be applied to elucidate changes in transporter activity in disease.
Shawn Pei Feng Tan, Marie‐Emilie Willemin, Jan Snoeys, Hong Shen, Amin Rostami‐Hodjegan, Daniel Scotcher, Aleksandra Galetin   +6 more
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Luminescence spectroscopy of pyridoxic acid and pyridoxic acid bound to proteins [PDF]

European Journal of Biochemistry, 1994
Luminescence techniques, i.e. fluorescence and phosphorescence, have been employed to study pyridoxic acid bound to proteins through a stable amide linkage. Proteins tagged with 4‐pyridoxic acid display the following fluorescence properties: (a) emission and excitation spectra centered at around 430 and 320 nm, respectively; (b) fluorescence quantum ...
Oh‐Shin KWON, Manuel Blázquez, Jorge E. Churchich   +2 more
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Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects [PDF]

Journal of Pharmacology and Experimental Therapeutics, 2018
Plasma pyridoxic acid (PDA) and homovanillic acid (HVA) were recently identified as novel endogenous biomarkers of organic anion transporter (OAT) 1/3 function in monkeys.
Hong Shen, Vinay K. Holenarsipur, T. Thanga Mariappan, Dieter M. Drexler, Joseph L. Cantone, K Prabhakar, Shashyendra Singh Gautam, Yueping Zhang, Jinping Gan, Petia Shipkova, Punit Marathe, W. Griffith Humphreys   +11 more
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Elevated plasma 4-pyridoxic acid in renal insufficiency [PDF]

The American Journal of Clinical Nutrition, 2002
Renal insufficiency is associated with altered vitamin B-6 metabolism. We have observed high concentrations of 4-pyridoxic acid, the major catabolite of vitamin B-6 metabolism, in plasma during renal insufficiency.The objective was to evaluate the renal handling of 4-pyridoxic acid and the effects of renal dysfunction on vitamin B-6 metabolism.We ...
Stephen P, Coburn, Robert D, Reynolds, J Dennis, Mahuren, Wayne E, Schaltenbrand, Yao, Wang, Karen L, Ericson, Michael P, Whyte, Yvonne M, Zubovic, Paula J, Ziegler, David L, Costill, William J, Fink, David R, Pearson, Thomas A, Pauly, K George, Thampy, Jacobo, Wortsman   +14 more
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Integrated Analysis of Proteomics and Metabolomics for Heat Stress in Chinese Holstein Cows [PDF]

Animals
Heat stress (HS) severely significantly reduces milk yield and causes substantial economic losses of dairy cows. TMT-based proteomes and an untargeted metabolomics approach were used to conduct the proteomics and metabolomics in heat-stressed (HS, n = 6)
Xiao Wang, Yinglin Yuan, Fen Pei, Jian Yang, Chenchen Wang, Peng Bao, Xiuxin Zhao, Huiming Liu, Hongding Gao, Minghai Hou, Yundong Gao, Jianbin Li, Dan Hao, Rongling Li   +13 more
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High-throughput untargeted metabolomic profiling of urinary biomarkers in acute myocarditis patients: a cross-sectional study [PDF]

Scientific Reports
Acute myocarditis, characterized by inflammatory myocardial injury, significantly risks heart failure and sudden death. Despite its severity, specific biomarkers are lacking.
Cui-mei Zhao, Xiu-zhen Long, Ke-yi Wang, Shao-xin Tian, Ying-ran Li, Wen-yuan Zhang   +5 more
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Association between vitamin B6 status and eczema in children and adolescents: results from the NHANES database [PDF]

Frontiers in Pediatrics
AimThere are few studies investigating the relationship between vitamin B6 status and the odds of eczema in children and adolescents. Hereby, this study aims to explore the association between vitamin B6 status and eczema in children and adolescents ...
Guimei Du, Xinghui Li
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EFFECT OF DIETARY PROTEIN LEVEL ON PYRIDO-XAL CONTENT IN TISSUES AND EXCRETION OF PYRIDOXIC ACID INTO UPINE IN NORMAL OR PYRIDOXINE-DEFICIENT RAT

Journal of Nutritional Science and Vitaminology, 1973
Rats were fed diets containing different levels of protein with or without pyridoxine. The growth of rats receiving the high-protein diet without pyridoxine was severely retarded.
Reiko Itoh, Mitsuko Okada
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Contents of All Forms of Vitamin B6, Pyridoxine-^|^beta;-Glucoside and 4-Pyridoxic Acid in Mature Milk of Japanese Women According to 4-Pyridoxolactone-Conversion High Performance Liquid Chromatography

Journal of Nutritional Science and Vitaminology, 2013
The contents of six vitamin B6 forms, pyridoxine-β-glucoside, and 4-pyridoxic acid in mature milk of 20 Japanese lactating women consuming ordinary Japanese foods were determined by a 4-pyridoxolactone-conversion HPLC method.
Toshiharu Yagi, Saya IWAMOTO, Rie MIZUSEKI, Michi Furuya, Kazuko Nakayama   +4 more
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