Results 1 to 10 of about 2,422 (193)
Spectrophotometric Methods for the Assay of Pyrilamine Maleate Using Chromogenic Reagents [PDF]
E-Journal of Chemistry, 2010 Simple, accurate and reproducible UV spectrophotometric methods were established for the assay of pyrilamine maleate (PYRA) based on the formation of oxidative coupling and precipitation, charge transfer complexation products.
V. Annapurna +3 more
doaj +2 more sources
Positive chronotropic action of HCN channel antagonism in human collecting lymphatic vessels [PDF]
Physiological Reports, Volume 10, Issue 16, August 2022., 2022 Hyperpolarisation‐activated cyclic‐nucleotide gated (HCN) channels primarily determine sinoatrial pacemaking. In human lymphatic vessels HCN channel proteins are also expressed but have a negligible functional role in ex vivo phasic activity when investigated using the HCN inhibitors ivabradine, ZD7288 and caesium.
Jens Majgaard +4 more
wiley +2 more sources
The role of endocardial endothelium in the effect of histamine on myocardial contractions of histamine H1 and H2 receptor blockade [PDF]
Praxis Medica, 2016 Endocardial endothelium (EE) is a barrier which controls the passage of macromolecules and fluids between the blood and the adjacent miocardial interstitium. At the same time it is the place of synthesis of numerous endothelial mediators. Histamine as an
Smiljić Sonja +4 more
doaj +1 more source
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
British Journal of Pharmacology, Volume 180, Issue S2, Page S23-S144, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander +165 more
wiley +1 more source
Improved PIEZO1 agonism through 4‐benzoic acid modification of Yoda1
British Journal of Pharmacology, Volume 180, Issue 16, Page 2039-2063, August 2023., 2023 Background and Purpose The protein PIEZO1 forms mechanically activated, calcium‐permeable, non‐selective cation channels in numerous cell types from several species. Options for pharmacological modulation are limited and so we modified a small‐molecule agonist at PIEZO1 channels (Yoda1) to increase the ability to modulate these channels.
Gregory Parsonage +18 more
wiley +1 more source
Neurogastroenterology &Motility, Volume 35, Issue 7, July 2023., 2023 Low molecular extracts from birch, ragweed, and hazel pollen strongly excite enteric and DRG neurons. Nerve activation was mediated by histamine in birch and ragweed, but not in hazel pollen extracts. Abstract Background Non‐allergenic, low molecular weight components of pollen grains are suspected to trigger changes in gut functions, sometimes leading
Sabine Buhner +7 more
wiley +1 more source
The transport function of the human lymphatic system—A systematic review
Physiological Reports, Volume 11, Issue 11, June 2023., 2023 Abstract Physiological properties and function of the lymphatic system is still somewhat of a mystery. We report the current knowledge about human lymphatic vessel contractility and capability of adaptation. A literature search in PubMed identified studies published January 2000–September 2022.
Lene Thorup +4 more
wiley +1 more source
Journal of Cell Communication and Signaling, Volume 17, Issue 1, Page 151-165, March 2023., 2023 Graphical abstract Xing et al. (2022) investigated the critical role of MIG6 in vascular permeability. MIG6 deficiency promotes VEGFA‐induced vascular permeability via activation of PLCγ1‐Ca2+‐eNOS signaling and perturbation of the balance in RAC1/RHOA activation, resulting in endothelial barrier disruption.
Liying Xing +12 more
wiley +1 more source
Revista Brasileira de Anestesiologia, 2009 JUSTIFICATIVA E OBJETIVOS: Os receptores de histamina mediam vias nociceptivas principalmente no sistema nervoso central. Alguns estudos mostraram efeito analgésico de antagonistas de receptor de histamina no sistema nervoso periférico. Não está claro se
Hazem Adel Ashmawi +3 more
doaj +1 more source
Bioactive Compounds in Ficus Fruits, Their Bioactivities, and Associated Health Benefits: A Review
Journal of Food Quality, Volume 2022, Issue 1, 2022., 2022 Bioactive compounds are secondary metabolites synthesized by plants for maintaining homeostasis; however, they also modulate metabolic processes and demonstrate valuable effects in the human body. The fig was cherished as food and for its pharmaceutical properties.
Ankita Walia +7 more
wiley +1 more source