Pyrilamine in the horse: detection and pharmacokinetics of pyrilamine and its major urinary metabolite O-desmethylpyrilamine. [PDF]
Journal of Veterinary Pharmacology and Therapeutics, 2009 Pyrilamine is an antihistamine used in human and veterinary medicine. As antihistamines produce central nervous system effects in horses, pyrilamine has the potential to affect the performance of racehorses. In the present study,O‐desmethylpyrilamine (O‐DMP) was observed to be the predominant equine urinary metabolite of pyrilamine.
L. Dirikolu +7 more
semanticscholar +4 more sources
Spectrophotometric Methods for the Assay of Pyrilamine Maleate Using Chromogenic Reagents [PDF]
E-Journal of Chemistry, 2010 Simple, accurate and reproducible UV spectrophotometric methods were established for the assay of pyrilamine maleate (PYRA) based on the formation of oxidative coupling and precipitation, charge transfer complexation products.
V. Annapurna +3 more
doaj +4 more sources
Pyrilamine/Pamabrom/Acetaminophen [PDF]
Definitions, 2020 National Cancer Institute
semanticscholar +3 more sources
The Effects of Pyrilamine on the Selectivity of Phonotaxis
, 2012 Hormones modulate phonotactic behaviors of female crickets (Acheta domesticus). This project seeks to observe the changes in phonotactic behavior when anti-histamine is injected in the prothoracic ganglion.
K. Chung
semanticscholar +4 more sources
Region-independent active CNS net uptake of marketed H+/OC antiporter system substrates. [PDF]
Front Cell NeurosciThe pyrilamine-sensitive proton-coupled organic cation (H+/OC) antiporter system facilitates the active net uptake of several marketed organic cationic drugs across the blood-brain barrier (BBB).
Bällgren F +5 more
europepmc +2 more sources
The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells. [PDF]
Fluids Barriers CNSBackground Triptans are anti-migraine drugs with a potential central site of action. However, it is not known to what extent triptans cross the blood–brain barrier (BBB).
Svane N +8 more
europepmc +2 more sources
Oceanapia magna Sponge Presents Dual Effect on the Gastrointestinal Motility of Rodents: In Vitro and In Vivo Assays. [PDF]
Front Pharmacol, 2020 Oceanapia magna Santos-Neto, Nascimento, Cavalcanti and Pinheiro sponges are distributed across tropical worldwide seas. Some studies of marine products have shown interesting activities in smooth muscle models.
Pereira JC +9 more
europepmc +2 more sources
Comparative analysis of the uptake of the H<sup>+</sup>/OC antiporter substrate oxycodone across and into brain endothelial and parenchymal cells with in vitro-in vivo extrapolation. [PDF]
Fluids Barriers CNSBackground In vitro evaluation of substances utilizing the putative proton‑coupled organic cation (H+/OC) antiporter for active uptake across the blood-brain barrier (BBB) and brain cell membranes requires a thorough understanding of cellular ...
Bällgren F +8 more
europepmc +2 more sources
The Active Glucuronide Metabolite of the Brain Protectant IMM-H004 with Poor Blood-Brain Barrier Permeability Demonstrates a High Partition in the Rat Brain via Multiple Mechanisms. [PDF]
PharmaceuticsBackground: Glucuronidation is an essential metabolic pathway for a variety of drugs. IMM-H004 is a novel neuroprotective agent against ischemic stroke, and its glucuronide metabolite IMM-H004G exhibits similar pharmacological activity.
Jiang J +6 more
europepmc +2 more sources
Disruption of histamine/H1R signaling pathway represses cardiac differentiation and maturation of human induced pluripotent stem cells. [PDF]
Stem Cell Res Ther, 2020 Background The efficiency and quality of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are crucial for regenerative medicine, disease modeling, drug screening, and the study of the development events during cardiac specification.
Zhu X +9 more
europepmc +2 more sources