Results 1 to 10 of about 3,638 (238)

Pyrilamine in the horse: detection and pharmacokinetics of pyrilamine and its major urinary metaboliteO‐desmethylpyrilamine [PDF]

Journal of Veterinary Pharmacology and Therapeutics, 2009
Pyrilamine is an antihistamine used in human and veterinary medicine. As antihistamines produce central nervous system effects in horses, pyrilamine has the potential to affect the performance of racehorses. In the present study,O‐desmethylpyrilamine (O‐DMP) was observed to be the predominant equine urinary metabolite of pyrilamine.
Levent Dirikolu, W. E. Woods, W. Karpiesiuk, Thomas Tobin, M. Fisher, J. D. Harkins, Richard S. Gates, Andreas F. Lehner   +7 more
semanticscholar   +5 more sources

Spectrophotometric Methods for the Assay of Pyrilamine Maleate Using Chromogenic Reagents [PDF]

Journal of Chemistry, 2010
Simple, accurate and reproducible UV spectrophotometric methods were established for the assay of pyrilamine maleate (PYRA) based on the formation of oxidative coupling and precipitation, charge transfer complexation products. Method A includes the oxidative coupling reaction of PYRA with 3‐methyl‐2‐benzathiazolinone hydrazone (MBTH) in presence of Ce ...
G. Jyothi, B. B. V. Sailaja, V. Annapurna, V. Nagalakshmi   +3 more
doaj   +5 more sources

Naproxen, paracetamol and pamabrom versus paracetamol, pyrilamine and pamabrom in primary dysmenorrhea: a randomized, double-blind clinical trial

Medwave, 2016
Resumen INTRODUCCIÓN La dismenorrea primaria es causada por la descarga de las prostaglandinas en el tejido uterino. Por lo tanto, los fármacos antiinflamatorios no esteroideos son la terapia inicial para la dismenorrea.
Mario I. Ortiz, Gabriela Murguía-Cánovas, Laura C. Vargas-López   +2 more
doaj   +3 more sources

Comparison of Pulmonary Accumulation of Pyrilamine and Pyrilamine N-oxide

Japanese Journal of Pharmacology, 1985
Our previous studies have indicated that a phenothiazine drug, chlorpromazine, and a tricyclic antidepressant, imipramine, are metabolized by the isolated perfused rat lungs via N-oxidation from whence their N-oxides are released into the circulation. This work was undertaken to compare the pulmonary accumulation of another pneumophilic tertiary amine ...
Kengo Nakai, Susumu Fujisawa, Yoshio Ohmiya   +2 more
openaire   +5 more sources

Region-independent active CNS net uptake of marketed H⁺/OC antiporter system substrates. [PDF]

Front Cell Neurosci
The pyrilamine-sensitive proton-coupled organic cation (H+/OC) antiporter system facilitates the active net uptake of several marketed organic cationic drugs across the blood-brain barrier (BBB).
Bällgren F, Hu Y, Li S, van de Beek L, Hammarlund-Udenaes M, Loryan I.   +5 more
europepmc   +2 more sources

Pyrilamine and O-Desmethylpyrilamine Detection in Equine Serum and Urine [PDF]

Journal of Analytical Toxicology, 2008
Pyrilamine (mepyramine) is an H1-receptor antagonist used in human and veterinary medicine. It has the potential to produce central nervous system effects in horses and therefore may have some impact on an outcome of a horse race. A single oral dose of pyrilamine (300 mg/horse) was given to three animals.
Marc Benoit, Adam Negrusz, Salvador Flores, Laura Hurt, Joseph A. Lokanc, David Mayer, Donna Pilipiak, Lisa Taddei, Kelly Lingen, Dawn Folker-Calderon, Katherine Lingner, Brendan Heffron, Esau Cardenas   +12 more
openaire   +4 more sources

Effects of membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver of drugs: A microdialysis study in rats. [PDF]

Pharmacol Res Perspect, 2021
Unbound concentrations of of 14 commercial drugs in rat liver, muscle, and blood Abstract The unbound concentrations of 14 commercial drugs, including five non‐efflux/uptake transporter substrates—Class I, five efflux transporter substrates—class II and four influx transporter substrates—Class III, were simultaneously measured in rat liver, muscle, and
Wang S, Chen C, Guan C, Qiu L, Zhang L, Zhang S, Zhou H, Du H, Li C, Wu Y, Chang H, Wang T.   +11 more
europepmc   +2 more sources

Positive chronotropic action of HCN channel antagonism in human collecting lymphatic vessels. [PDF]

Physiol Rep, 2022
Hyperpolarisation‐activated cyclic‐nucleotide gated (HCN) channels primarily determine sinoatrial pacemaking. In human lymphatic vessels HCN channel proteins are also expressed but have a negligible functional role in ex vivo phasic activity when investigated using the HCN inhibitors ivabradine, ZD7288 and caesium.
Majgaard J, Skov FG, Kim S, Hjortdal VE, Boedtkjer DMB.   +4 more
europepmc   +2 more sources

Subchronic Studies of Pyrilamine in Fischer 344 Rats [PDF]

Journal of the American College of Toxicology, 1993
This study was designed to determine the subchronic effects of the antihistamine, pyrilamine maleate, and to establish dose levels for a 2-year chronic study. Six male and six female F344 rats received dietary pyrilamine concentrations of 0, 392, 783, 1563, 3122, or 6276 ppm (as the free base) for 14 days.
Robert L. Morrissey, William T. Allaben, David W. Gaylor, David L. Greenman   +3 more
openaire   +3 more sources

Chronic Toxicity/Carcinogenicity Study of Pyrilamine in B6C3F1 Mice [PDF]

Journal of the American College of Toxicology, 1995
The chronic toxicity and carcinogenicity of pyrilamine maleate were evaluated in B6C3F1 mice by feeding for up to 2 years to groups of 60 male or female mice at dietary levels of 0,150, 750, or 1,500 ppm (as the free base). Up to 12 mice per sex and dose group were killed after 65 weeks for clinical chemistry, hematology, and histopathologic ...
Robert Dahlgren, David L. Greenman, Gerald M. Cronin, William T. Allaben, Richard R. Allen   +4 more
openaire   +3 more sources