Results 11 to 20 of about 3,638 (238)
Design, Synthesis, and Blood–Brain Barrier Transport Study of Pyrilamine Derivatives as Histone Deacetylase Inhibitors [PDF]
ACS Medicinal Chemistry Letters, 2018 We designed and synthesized a pyrilamine derivative 1 as a selective class I HDAC inhibitor that targets pyrilamine-sensitive proton-coupled organic cation antiporter (PYSOCA) at the blood-brain barrier (BBB).
Yoshiharu Deguchi +2 more
exaly +3 more sources
The Effects of Pyrilamine on the Selectivity of Phonotaxis
, 2023 Hormones modulate phonotactic behaviors of female crickets (Acheta domesticus). This project seeks to observe the changes in phonotactic behavior when anti-histamine is injected in the prothoracic ganglion. The anti-histamine used, pyrilamine, resulted in older, unselective females becoming more selective to the male calling songs.
Kristin Chung
semanticscholar +4 more sources
Journal of the Mexican Chemical Society, 2017 A simple, specific and accurate stability indicating RPHPLC method was developed for the determination of acetaminophen, pamabrom and pyrilamine maleate simultaneously in pharmaceutical dosage forms.
Muhammad Ashfaq
exaly +4 more sources
The evidence for histamine H3 receptor-mediated endothelium-dependent relaxation in isolated rat aorta [PDF]
Mediators of Inflammation, 1995 The presence of histamine H3 receptors was evaluated on the rat aorta endothelium. In the presence of pyrilamine (1 nM, 7 nM, 10 nM) or thioperamide (1 nM, 10 nM, 30 nM) the concentration–response curve for histamine-induced (0.1 nM − 0.01 mM ...
D. M. Djuric, I. Z. Andjelkovic
doaj +4 more sources
The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells. [PDF]
Fluids Barriers CNSBackground Triptans are anti-migraine drugs with a potential central site of action. However, it is not known to what extent triptans cross the blood–brain barrier (BBB).
Svane N +8 more
europepmc +2 more sources
Subchronic Studies of Pyrilamine in B6C3F1 Mice [PDF]
Journal of the American College of Toxicology, 1993 The purpose of this study was to determine the effects of subchronic exposure to the antihistamine pyrilamine maleate and to establish dosage levels to use in a 2-year chronic study. A 14-day repeated-dose study in male and female B6C3F1 mice at dietary levels of pyrilamine (as the free base) of 0, 196, 392, 783, 1563, or 3122 ppm revealed no ...
Robert L. Morrissey +3 more
openaire +3 more sources
Typical and Atypical Antipsychotic Drugs Increase Extracellular Histamine Levels in the Rat Medial Prefrontal Cortex: Contribution of Histamine H1 Receptor Blockade [PDF]
Frontiers in Psychiatry, 2012 Atypical antipsychotics such as clozapine and olanzapine have been shown to enhance histamine turnover and this effect has been hypothesized to contribute to their improved therapeutic profile compared to typical antipsychotics.
Kjell A Svensson
doaj +4 more sources