Results 11 to 20 of about 3,728 (241)
Medwave, 2016 INTRODUCTION Dysmenorrhea is caused by the discharge of prostaglandins into the uterine tissue; therefore, non-steroidal anti-inflammatory drugs (NSAIDs) are the established initial therapy for dysmenorrhea.
M. Ortiz +4 more
semanticscholar +2 more sources
ACS Medicinal Chemistry Letters, 2018 We designed and synthesized a pyrilamine derivative 1 as a selective class I HDAC inhibitor that targets pyrilamine-sensitive proton-coupled organic cation antiporter (PYSOCA) at the blood-brain barrier (BBB).
Seiya Hiranaka +9 more
semanticscholar +2 more sources
Comparison of Pulmonary Accumulation of Pyrilamine and Pyrilamine N-oxide
Japanese Journal of Pharmacology, 1985 Our previous studies have indicated that a phenothiazine drug, chlorpromazine, and a tricyclic antidepressant, imipramine, are metabolized by the isolated perfused rat lungs via N-oxidation from whence their N-oxides are released into the circulation. This work was undertaken to compare the pulmonary accumulation of another pneumophilic tertiary amine ...
Y, Ohmiya, S, Fujisawa, K, Nakai
openaire +4 more sources
Pyrilamine and O-Desmethylpyrilamine Detection in Equine Serum and Urine [PDF]
Journal of Analytical Toxicology, 2008 Pyrilamine (mepyramine) is an H1-receptor antagonist used in human and veterinary medicine. It has the potential to produce central nervous system effects in horses and therefore may have some impact on an outcome of a horse race. A single oral dose of pyrilamine (300 mg/horse) was given to three animals.
Marc, Benoit +12 more
openaire +3 more sources
, 2017 A simple, specific and accurate stability indicating RPHPLC method was developed for the determination of acetaminophen, pamabrom and pyrilamine maleate simultaneously in pharmaceutical dosage forms.
Atif Saleem +5 more
semanticscholar +3 more sources
Subchronic Studies of Pyrilamine in B6C3F1 Mice [PDF]
Journal of the American College of Toxicology, 1993 The purpose of this study was to determine the effects of subchronic exposure to the antihistamine pyrilamine maleate and to establish dosage levels to use in a 2-year chronic study. A 14-day repeated-dose study in male and female B6C3F1 mice at dietary levels of pyrilamine (as the free base) of 0, 196, 392, 783, 1563, or 3122 ppm revealed no ...
David L. Greenman +3 more
openaire +2 more sources
Combination Therapies of the Neurotransmitter-Targeting Drugs Dextromethorphan, Pyrilamine and Lorcaserin in a Rat Model of Nicotine Addiction [PDF]
, 2014 Given the current epidemic of nicotine dependence, the study of interactions between neurotransmitter receptor-targeting molecules to discover possible new forms of smoking cessation treatment is of great importance.
Scott Alan Briggs
openalex +3 more sources
Effects of the histamine H1 receptor blocker, pyrilamine, on spontaneous locomotor activity of rats with long‐term portacaval anastomosis [PDF]
Hepatology, 2000 V. Lozeva +7 more
semanticscholar +2 more sources
Pharmacology of [3H]‐pyrilamine binding and of the histamine‐induced inositol phosphates generation, intracellular Ca2+‐mobilization and cytokine release from human corneal epithelial cells [PDF]
British Journal of Pharmacology, 1998 N. Sharif +3 more
semanticscholar +2 more sources