Oceanapia magna Sponge Presents Dual Effect on the Gastrointestinal Motility of Rodents: In Vitro and In Vivo Assays. [PDF]
Front Pharmacol, 2020 Oceanapia magna Santos-Neto, Nascimento, Cavalcanti and Pinheiro sponges are distributed across tropical worldwide seas. Some studies of marine products have shown interesting activities in smooth muscle models.
Pereira JC +9 more
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The Active Glucuronide Metabolite of the Brain Protectant IMM-H004 with Poor Blood-Brain Barrier Permeability Demonstrates a High Partition in the Rat Brain via Multiple Mechanisms. [PDF]
PharmaceuticsBackground: Glucuronidation is an essential metabolic pathway for a variety of drugs. IMM-H004 is a novel neuroprotective agent against ischemic stroke, and its glucuronide metabolite IMM-H004G exhibits similar pharmacological activity.
Jiang J +6 more
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Salvia fruticosa Induces Vasorelaxation In Rat Isolated Thoracic Aorta: Role of the PI3K/Akt/eNOS/NO/cGMP Signaling Pathway [PDF]
Scientific Reports, 2017 Salvia fruticosa (SF) Mill. is traditionally used for its antihypertensive actions. However, little is known about its pharmacologic and molecular mechanisms of action.
M. Akhtar Anwar +5 more
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Endothelium-dependent relaxation of rat aorta to a histamine H3 agonist is reduced by inhibitors of nitric oxide synthase, guanylate cyclase and Na+,K+-ATPase [PDF]
Mediators of Inflammation, 1996 The possible involvement of different effector systems (nitric oxide synthase, guanylate cyclase, β-adrenergic and muscarinic cholinergic receptors, cyclooxygenase and lipoxygenase, and Na+,K+-ATPase) was evaluated in a histamine H3 receptor agonist ...
D. M. Djuric +2 more
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Marjoram Relaxes Rat Thoracic Aorta Via a PI3-K/eNOS/cGMP Pathway [PDF]
Biomolecules, 2019 Despite pharmacotherapeutic advances, cardiovascular disease (CVD) remains the primary cause of global mortality. Alternative approaches, such as herbal medicine, continue to be sought to reduce this burden.
Adnan Badran +7 more
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Frontiers in Pharmacology, 2017 The involvement of histamine H3 receptors (H3Rs) in memory is well known, and the potential of H3R antagonists in therapeutic management of neuropsychiatric diseases, e.g., Alzheimer disease (AD) is well established.
Dorota ŁAżewska +2 more
exaly +3 more sources
Synergistic interaction between diclofenac and pyrilamine on nociception, inflammation, and gastric damage in rats [PDF]
Canadian Journal of Physiology and Pharmacology, 2016 Experiments using nonsteroidal anti-inflammatory drugs (NSAIDs) alone have produced limited antinociceptive effects in animal models. For this reason, the number of studies involving the administration of NSAIDs along with an adjuvant drug harboring ...
Mario I. Ortíz
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Effects of the histamine H1receptor blocker, pyrilamine, on spontaneous locomotor activity of rats with long-term portacaval anastomosis [PDF]
Hepatology, 2000 V. Lozeva +7 more
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Pharmacology of [3H]‐pyrilamine binding and of the histamine‐induced inositol phosphates generation, intracellular Ca2+‐mobilization and cytokine release from human corneal epithelial cells [PDF]
British Journal of Pharmacology, 1998 Najam A. Sharif +3 more
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Drug Metabolism And Disposition, 2023 Our recent study has revealed that SLC49A4, known as disrupted in renal carcinoma 2, is an H+-coupled lysosomal exporter for pyridoxine (vitamin B6), a cationic compound.
Shogo Akino +4 more
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