Results 31 to 40 of about 3,728 (241)

Bioactive Compounds in Ficus Fruits, Their Bioactivities, and Associated Health Benefits: A Review

Journal of Food Quality, Volume 2022, Issue 1, 2022., 2022
Bioactive compounds are secondary metabolites synthesized by plants for maintaining homeostasis; however, they also modulate metabolic processes and demonstrate valuable effects in the human body. The fig was cherished as food and for its pharmaceutical properties.
Ankita Walia, Naveen Kumar, Rajat Singh, Harish Kumar, Vikas Kumar, Ravinder Kaushik, Avvaru Praveen Kumar, Milan Stankovic   +7 more
wiley   +1 more source

Efeito analgésico de antagonistas do receptor da histamina H1 em modelo de dor provocada por formalina em ratos Efecto analgésico de antagonistas del receptor de la histamina H1 en un modelo de dolor provocado por formalina en ratones Analgesic effects of H1 receptor antagonists in the rat model of formalin-induced pain

Revista Brasileira de Anestesiologia, 2009
JUSTIFICATIVA E OBJETIVOS: Os receptores de histamina mediam vias nociceptivas principalmente no sistema nervoso central. Alguns estudos mostraram efeito analgésico de antagonistas de receptor de histamina no sistema nervoso periférico. Não está claro se
Hazem Adel Ashmawi, Leandro Mamede Braun, Angela Maria Sousa, Irimar de Paula Posso   +3 more
doaj   +1 more source

The widely used antihistamine mepyramine causes topical pain relief through direct blockade of nociceptor sodium channels

The FASEB Journal, Volume 35, Issue 12, December 2021., 2021
Abstract Mepyramine, a first‐generation antihistamine targeting the histamine H(1) receptor, was extensively prescribed to patients suffering from allergic reactions and urticaria. Serious adverse effects, especially in case of overdose, were frequently reported, including drowsiness, impaired thinking, convulsion, and coma.
Jizhe Hao, Lucie Brosse, Caroline Bonnet, Myriam Ducrocq, Françoise Padilla, Virginie Penalba, Angélique Desplat, Jérôme Ruel, Patrick Delmas   +8 more
wiley   +1 more source

Ameliorative Effect of a Hippocampal Metabotropic Glutamate– Receptor Agonist on Histamine H1 Receptor Antagonist–Induced Memory Deficit in Rats

Journal of Pharmacological Sciences, 2010
This study was performed to investigate the ameliorative effects of metabotropic glutamate (mGlu)-receptor agonists on histamine H1 receptor antagonist–induced spatial memory deficit and the decrease in hippocampal theta activity in rats. Intraperitoneal
Takayoshi Masuoka, Azusa Mikami, Chiaki Kamei   +2 more
doaj   +1 more source

Blocking Histamine H1 Improves Learning and Mnemonic Dysfunction in Mice With Social Isolation Plus Repeated Methamphetamine Injection

Journal of Pharmacological Sciences, 2008
The aim of this study was to investigate the effects of histamine H1 and H3 antagonists on learning and mnemonic dysfunction in mice. Two H1 antagonists, pyrilamine and clozapine, and the prototypic H3 antagonist thioperamide were used to study the role ...
Feiyong Jia, Jalal Izadi Mobarakeh, Hongmei Dai, Motohisa Kato, Ajing Xu, Tomohiro Okuda, Eiko Sakurai, Nobuyuki Okamura, Kazuhiro Takahashi, Kazuhiko Yanai   +9 more
doaj   +1 more source

Histamine inhibits adrenocortical cell proliferation but does not affect steroidogenesis. [PDF]

, 2014
Histamine (HA) is a neurotransmitter synthesized in most mammalian tissues exclusively by histidine decarboxylase enzyme. Among the plethora of actions mediated by HA, the modulatory effects on steroidogenesis and proliferation in Leydig cells (LCs) have
Mondillo, Carolina, Monzón, Casandra Margarita, Pagotto, Romina María del Luján, Pereyra, Elba Nora, Pignataro, Omar Pedro   +4 more
core   +2 more sources

Prokinetic and laxative effects of the crude methanolic extract of Viola betonicifolia whole plant in rodents [PDF]

, 2013
Background: The present study was aimed to provide ethnopharmacological basis for the medicinal use of Viola betonicifolia whole plant in indigestion and constipation.
Gilani, Anwar, Khan, Haroon, Muhammad, Naveed, Rehman,, Najeeb, Saeed, Muhammad   +4 more
core   +2 more sources

Cytokine responses of intraepithelial lymphocytes are regulated by histamine H2 receptor [PDF]

, 2009
Backgrounds. Histamine participates in the immune regulation of several gastrointestinal diseases. However, the effect of histamine on intestinal intraepithelial lymphocytes (IELs), the front line of intestinal mucosal immune system, is not well ...
A Di Sabatino, A Hayday, A Mazzoni, Akira Hishida, B Lagier, C Lundqvist, CA Akdis, CA Akdis, CC Fox, D Montufar-Solis, E Bolton, E Masini, G Barbara, G Caron, G Monteleone, H Cheroutre, H Cheroutre, H Kiyono, HD Lim, HK Takahashi, IJ Elenkov, K Hoshino, K Takahashi, K Tomita, Kosuke Takagaki, L Knutson, L Lefrancois, LB Hough, LB Svendsen, LE Sander, M Jutel, M Kawaguchi, M Watanabe, Mutsuhiro Ikuma, N Osna, N Osna, P Parronchi, R Boismenu, R Leurs, RL Mosley, S Bischoff, S Kapoor, S Matsumoto, S Takamatsu, S Winterkamp, Satoshi Osawa, T Morichika, T Taguchi, T Taguchi, TA Barrett, Takahisa Furuta, Takanori Yamada, WJ Adams, WJ Adams, Y Horio, Y Sonobe, Yasuhiro Takayanagi, Yasushi Hamaya, Yoshiaki Horio   +58 more
core   +1 more source

The evidence for histamine H3 receptor-mediated endothelium-dependent relaxation in isolated rat aorta

Mediators of Inflammation, 1995
The presence of histamine H3 receptors was evaluated on the rat aorta endothelium. In the presence of pyrilamine (1 nM, 7 nM, 10 nM) or thioperamide (1 nM, 10 nM, 30 nM) the concentration–response curve for histamine-induced (0.1 nM − 0.01 mM ...
D. M. Djuric, I. Z. Andjelkovic
doaj   +1 more source

Uptake Study in Lysosome-Enriched Fraction: Critical Involvement of Lysosomal Trapping in Quinacrine Uptake but Not Fluorescence-Labeled Verapamil Transport at Blood-Retinal Barrier

Pharmaceutics, 2020
Lysosomal trapping at the blood–retinal barrier (BRB) was investigated through quinacrine and fluorescence-labeled verapamil (EFV) uptake. Quinacrine uptake by conditionally immortalized rat retinal capillary endothelial (TR-iBRB2) cells suggested ...
Yoshiyuki Kubo, Miki Yamada, Saki Konakawa, Shin-ichi Akanuma, Ken-ichi Hosoya   +4 more
doaj   +1 more source