Results 61 to 70 of about 3,638 (238)
Brazilian Journal of Medical and Biological Research, 1997 The possible role of histamine receptors in the hippocampal formation on the exploratory motivation and emotionality of the rat was studied. An elevated asymmetric plus-maze composed of 4 different arms (no walls, single high wall, high and low walls and
M.B. Ruarte, A.G. Orofino, E.O. Alvarez
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Species-specific pharmacology of maximakinin, an amphibian homologue of bradykinin: putative prodrug activity at the human B2 receptor and peptidase resistance in rats [PDF]
PeerJ, 2017 Maximakinin (MK), an amphibian peptide possessing the C-terminal sequence of bradykinin (BK), is a BK B2 receptor (B2R) agonist eliciting prolonged signaling.
Xavier Charest-Morin +3 more
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JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 7, Issue 12, Page 1207-1227, December 2024.Abstract Cognitive impairment affects around 19% of community‐dwelling older adults in the United States. Pharmacists can play a significant role in identifying and deprescribing cognitive‐impairing medications through cognitive‐focused medication reviews or as part of comprehensive medication management.
Jacob Stanton +4 more
wiley +1 more source
The role of GABA-B in sensorigating processing disorders in rat models, an autoradiographic study [PDF]
, 2019 INTRODUCTION: The process of sensorimotor gating is a neurological phenomenon referring to the brain’s ability to process and filter out stimuli in order to prevent an overflow of information.
Zhuang, Alex
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Journal of Molecular Recognition, Volume 37, Issue 5, September 2024.Abstract Doxepin is an antihistamine and tricyclic antidepressant that binds to the histamine H1 receptor (H1R) with high affinity. Doxepin is an 85:15 mixture of the E‐ and Z‐isomers. The Z‐isomer is well known to be more effective than the E‐isomer, whereas based on the crystal structure of the H1R/doxepin complex, the hydroxyl group of Thr1123.37 is
Hiroto Kaneko +5 more
wiley +1 more source
Indomethacin-antihistamine combination for gastric ulceration control [PDF]
, 1981 An anti-inflammatory and analgesic composition containing indomethacin and an H sub 1 or an H sub 2 histamine receptor antagonist in an amount sufficient to reduce gastric distress caused by the indomethacin is described.
Brown, P. A., Danellis, J. V.
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Inonotus obliquus attenuates histamine-induced microvascular inflammation.
PLoS ONE, 2019 Cell-to-cell communication is a key element of microvascular blood flow control, including rapidly carrying signals through the vascular endothelium in response to local stimuli.
Sumreen Javed +8 more
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British Journal of Clinical Pharmacology, Volume 90, Issue 9, Page 2236-2255, September 2024.Aims This study evaluated the use of machine learning to leverage drug absorption, distribution, metabolism and excretion (ADME) data together with physicochemical and pharmacological data to develop a novel anticholinergic burden scale and compare its performance to previously published scales.
Geofrey Oteng Phutietsile +2 more
wiley +1 more source
Indometh acin-antihistamine combination for gastric ulceration control [PDF]
, 1980 An anti-inflammatory and analgesic composition containing indomethacin and an H2 histamine receptor antagonist in an amount sufficient to reduce gastric distress caused by the indomethacin was developed.
Brown, P. A., Vernikos, J.
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Advanced Science, Volume 11, Issue 15, April 17, 2024.The potassium channel Slack is highly expressed in sensory neurons that sense itch. In this study, several new compounds that activate Slack are developed. It is found that the lead molecule, compound 6, effectively inhibits scratching elicited by multiple pruritogens in mice establishing Slack activation as a novel pharmacological strategy for the ...
Annika Balzulat +20 more
wiley +1 more source