Results 101 to 110 of about 314,968 (285)
Deuteration of Six‐Membered N‐Heteroarenes: Chemistry and Applications
Chemistry – A European Journal, EarlyView.Deuterated six‐membered N‐Heteroarenes (6NHetAr) are finding utility in an increasing repertoire of applications. Our paper comprehensively reviews synthetic approaches that have been reported for the deuteration of 6NHetAr and their fused counterparts while providing an overview of established and emerging applications for these materials.
Liju Raju +4 more
wiley +1 more source
Empirical LCAO parameters for $\pi$ molecular orbitals in planar organic molecules
, 2008 We present a parametrization within a simplified LCAO model (a type of Hueckel model) for the description of $\pi$ molecular orbitals in organic molecules containing $\pi$-bonds between carbon, nitrogen, or oxygen atoms with $sp^2$ hybridization, which ...
Hawke, Laurence +2 more
core +3 more sources
Versatile Palladium‐Catalyzed C‐H Arylation of Fluoroarenes with 2‐Chloropyridine Derivatives
Chemistry – A European Journal, EarlyView.Direct C─H arylation of fluoroarenes with 2‐chloropyridines is enabled by a simple Pd/SPhos system in isopropyl acetate. The method uses inexpensive reactants and shows broad scope and high yields. DFT computations explain reactivity and selectivity.
Federico Belnome +6 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.A novel synthetic route to 2′‐O,4′‐C‐spirocyclopentylene‐bridged nucleic acid (scpBNA2) monomers bearing thymine, guanine, and adenine nucleobases. The strategy integrates 2′,4′‐lactonization, transglycosylation, and intramolecular iodocyclization, thereby bypassing the 2′‐OH inversion step and providing scpBNA2 nucleoside building blocks for antisense
Riku Kumagai +3 more
wiley +1 more source
ChemMedChem, EarlyView.Rifamycin analogues with variably functionalized C‐3 extensions provide new insight into the role of this region for MTb inhibitory activity. In addition to potentially optimizing target engagement, this region can also be used to modulate physicochemical properties, an important consideration for optimizing antimycobacterial activity.
Clinton G. L. Veale +4 more
wiley +1 more source
ChemPhysChem, EarlyView.Reaction networks yielding spontaneous mirror‐symmetry breaking (SMSB) are revisited. All include a first‐order enantioselective autocatalysis, which, on its own, is unable to lead to SMSB. The coupling with the so‐called ancillary reactions (racemization, mutual inhibition, etc.) makes the racemic state unstable.
Josep M. Ribó +2 more
wiley +1 more source
Probing the excited state relaxation dynamics of pyrimidine nucleosides in chloroform solution [PDF]
, 2016 Katharina Röttger +7 more
openalex +1 more source
Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives
ChemPlusChem, EarlyView.Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley +1 more source
Cross-section calculations for positron scattering from pyrimidine over an energy range from 0.1 to 10000 eV [PDF]
, 2013 Ana García +7 more
openalex +1 more source