Results 101 to 110 of about 319,341 (367)

Disruption of nucleotide biosynthesis reprograms mitochondrial metabolism to inhibit adipogenesis

Journal of Lipid Research
A key organismal response to overnutrition involves the development of new adipocytes through the process of adipogenesis. Preadipocytes sense changes in the systemic nutrient status and metabolites can directly modulate adipogenesis.
Julia A. Pinette, Jacob W. Myers, Woo Yong Park, Heather G. Bryant, Alex M. Eddie, Genesis A. Wilson, Claudia Montufar, Zayedali Shaikh, Zer Vue, Elizabeth R. Nunn, Ryoichi Bessho, Matthew A. Cottam, Volker H. Haase, Antentor O. Hinton, Jessica B. Spinelli, Jean-Philippe Cartailler, Elma Zaganjor   +16 more
doaj   +1 more source

Intermediate metabolites of the pyrimidine metabolism pathway extend the lifespan of C. elegans through regulating reproductive signals

Aging, 2019
The pyrimidine metabolism pathway has important biological functions; it not only maintains appropriate pyrimidine pools but also produces bioactive intermediate metabolites.
Qin-Li Wan, Xiao Meng, Xiaodie Fu, Bohui Chen, Jing Yang, Hengwen Yang, Qinghua Zhou   +6 more
semanticscholar   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

Photoreactivation of Lethal Damage Induced in Hamster X Xenopus Hybrid Cells and Their Parentals by UV Light [PDF]

, 1987
A85 Xenopus cells that exhibited a high level of photoreactivation (PR) and V79B2 hamster cells that exhibited little PR were fused to produce the V79B2 x A85 cell line — a hybrid line which possessed a relatively stable karyotype, with most cells ...
Bohlender, David, Cruz, Emir, Griggs, H. Gaston, Williams, Stuart   +3 more
core   +2 more sources

Crystalizing the genetic code

, 2000
New developments are presented in the framework of the model introduced by the authors in refs. [1,2] and in which nucleotides as well as codons are classified in crystal bases of the quantum group U_q(sl(2)+sl(2)) in the limit q -> 0.
Frappat, L., Sciarrino, A., Sorba, P.
core   +2 more sources

His+ reversions Caused in Salmonella typhimurium by different types of ionizing radiation [PDF]

, 1988
The yield of his+ reversions in the Ames Salmonella tester strain TA2638 has been determined for 60Co γ rays, 140 kV X rays, 5.4 keV characteristic X rays, 2.2 MeV protons, 3.1 MeV α particles, and 18 MeV/U Fe ions.
Fitzek, M., Kellerer, Albrecht M., Roos, H., Thomas, W.-H.   +3 more
core   +1 more source

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

Advanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li, Jing Zhang, Lori Bulwith, Lee Niswander   +3 more
wiley   +1 more source

1-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

IUCrData, 2018
The title molecule, C6H6N4O, is essentially planar [dihedral angle between the rings = 0.46 (9)°]. The crystal structure consists of sheets of molecules lying parallel to (\overline{1}11) formed by a combination of N—H...O, C—H...O and C—H...H hydrogen ...
Mohamed El Hafi, Sanae Lahmidi, Mohammed Boulhaoua, Youssef Ramli, El Mokhtar Essassi, Joel T. Mague   +5 more
doaj   +1 more source

Genomic organization of nucleolin gene in carp fish: Evidence for several genes [PDF]

, 2006
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000200017&lng=es&nrm=isoThe protein nucleolin, functionally involved in the main steps of ribosome biogenesis, is codified by a single copy gene in mammals.
Alvarez, Marco, Molina, Alfredo, Navarro, Cristina, Quezada, Claudia, San Martín, Rody, Vera, Ines   +5 more
core   +2 more sources

Brain pyrimidine nucleotide synthesis and Alzheimer disease

Aging, 2019
Many patients suffering late-onset Alzheimer disease show a deficit in respiratory complex IV activity. The de novo pyrimidine biosynthesis pathway connects with the mitochondrial respiratory chain upstream from respiratory complex IV.
Alba Pesini, E. Iglesias, M. Bayona-Bafaluy, Nuria Garrido-Pérez, Patricia Meade, Paula Gaudó, Irene Jiménez-Salvador, P. Andrés‐Benito, J. Montoya, I. Ferrer, P. Pesini, E. Ruiz‐Pesini   +11 more
semanticscholar   +1 more source