Results 101 to 110 of about 151,536 (281)

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Structure-activity consideration of novel anticancer platinum pyrimidine "greens".

, 1987
Takehiko Shimura, Takenori Tomohiro, Kiyoshi Maruno, Yasuo Fujimoto, Yohmei Okuno   +4 more
openalex   +2 more sources

Underlying Mechanisms of the Treatment Efficacy of (R, S)‐Ketamine for Post‐Traumatic Stress Disorder and Depression: A Review

Medicine Advances, EarlyView.
Research shows that (R, S)‐ketamine and its stereoisomers effectively reduce symptoms of post‐traumatic stress disorder (PTSD) and treatment‐resistant depression, with (R)‐ketamine offering similar benefits with fewer side effects. Evidence highlights specific neural circuits and regions, including the dentate gyrus, prefrontal cortex, vCA3, dorsal ...
Thomas Edward Cutting, Richard Evans Hartman   +1 more
wiley   +1 more source

RESEARCHES ON PYRIMIDINES: PYRIMIDINE-NUCLEOSIDES

Journal of Biological Chemistry, 1913
Treat B. Johnson, Lewis H. Chernoff
openaire   +1 more source

Synthesis of 4'-Phenylated Pyrimidine C-Nucleosides

, 1980
Ryōji Noyori, T. Sato, Manabu Watanabe, Ryōji Noyori   +3 more
openalex   +1 more source

Novel pyrimidine-bichalcophene derivatives as corrosion inhibitors for copper in 1 M nitric acid solution

, 2021
Mai A. Khaled, Mohamed A. Ismail, Ahmed El-Hossiany, A. S. Fouda   +3 more
openalex   +2 more sources

NMR‐Based Structural Analysis of Highly Substituted Pyridines From Kondrat'eva Aza‐Diels–Alder Cycloadditions

Magnetic Resonance in Chemistry, EarlyView.
We report the results from a kinetic and mechanistic investigation of an inverse‐electron‐demand Diels–Alder (IEDDA) cycloaddition involving an oxazole‐type diene synthesized via an Ugi–Zhu multicomponent reaction (UZ‐3CR). ABSTRACT Pyridines are a crucial class of heterocycles with widespread applications in natural products, pharmaceuticals, and ...
Galdina V. Suárez‐Moreno, Francisco Méndez, Atilano Gutierrez‐Carrillo, Mónica A. Rincón‐Guevara, Yoarhy A. Amador‐Sánchez, Alejandro Islas‐Jácome, Eduardo González‐Zamora   +6 more
wiley   +1 more source

Infrared study of some 2-substituted-6-hydroxy-4-pyrimidine carboxylic acids: Correlation with MO-calculations

, 2000
Ljubinka J. Bogunovic, U.B. Mioč, Bratislav Jovanović, Ivan O. Juranić   +3 more
openalex   +2 more sources

STUDIES ON ANALOGS OF PURINES AND PYRIMIDINES [PDF]

, 1950
George H. Hitchings, Gertrude B. Elion, Elvira A. Falco, Peter B. Russell, Henry Vanderwerff   +4 more
openalex   +1 more source

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

ChemistryOpen, EarlyView.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda, Sami A. Al‐Hussain, Basant Farag, Mohamed El‐Naggar, Magdi E. A. Zaki, Emad S. A. Alhazmi, Adel S. M. Almohammadi, Sobhi M. Gomha   +7 more
wiley   +1 more source