Results 121 to 130 of about 153,260 (279)

Underlying Mechanisms of the Treatment Efficacy of (R, S)‐Ketamine for Post‐Traumatic Stress Disorder and Depression: A Review

Medicine Advances, EarlyView.
Research shows that (R, S)‐ketamine and its stereoisomers effectively reduce symptoms of post‐traumatic stress disorder (PTSD) and treatment‐resistant depression, with (R)‐ketamine offering similar benefits with fewer side effects. Evidence highlights specific neural circuits and regions, including the dentate gyrus, prefrontal cortex, vCA3, dorsal ...
Thomas Edward Cutting, Richard Evans Hartman   +1 more
wiley   +1 more source

Pyrimidine Homoribonucleosides: Synthesis, Solution Conformation, and Some Biological Properties [PDF]

, 1987
Piotr Lassota, J. T. Kuśmierek, Ryszard Stolarski, David Shugar   +3 more
openalex   +1 more source

Synthesis and anticancer evaluation of 4’-thio and 4’-sulfinyl pyrimidine nucleoside analogues

, 2021
Mieke Guinan, Ningwu Huang, Chris S. Hawes, Marcelo A. Lima, Gavin J. Miller, Mark E. B. Smith   +5 more
openalex   +1 more source

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

ChemistryOpen, EarlyView.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda, Sami A. Al‐Hussain, Basant Farag, Mohamed El‐Naggar, Magdi E. A. Zaki, Emad S. A. Alhazmi, Adel S. M. Almohammadi, Sobhi M. Gomha   +7 more
wiley   +1 more source

Pyrimidine-containing natural products: occurrences and biological activities. [PDF]

Nat Prod Bioprospect
Yao JN, Zhu Y, Chen HP, Chen Y.
europepmc   +1 more source

Synthesis of Pyrido[2,3‐d]Azolopyrimidinones: Design and Epidermal Growth Factor Receptor‐Targeted Molecular Docking Toward Novel Anticancer Leads

ChemistryOpen, EarlyView.
New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha, Sami A. Al‐Hussain, Basant Farag, AbdElAziz A. Nayl, Wesam Hussein, Abdelwahed R. Sayed, Magdi E. A. Zaki   +6 more
wiley   +1 more source

Correction: Novel pyrimidine-substituted chalcones: In vitro antioxidant properties and cytotoxic effects against human cancer cell lines. [PDF]

PLoS One
Nayak P, Shenoy VS, Upadhye V, Abass KS, Alsaidan OA, Soni M, Hajare ST.   +6 more
europepmc   +1 more source

Synthesis and biological evaluation of some new pyrimidines via a novel chalcone series

, 2008
Amit R. Trivedi, Dipti K. Dodiya, Naresh Ravat, Viresh H. Shah   +3 more
openalex   +2 more sources

Synthesis and biological evaluation of <i>N</i>/<i>O</i>-propargylated diarylpyrimidines as dual inhibitors of acetylcholinesterase and monoamine oxidase. [PDF]

RSC Adv
Kumar N, Jangid K, Kumar V, Dwivedi AR, Kumar V, Devi B, Arora T, Parkash J, Kumar V.   +8 more
europepmc   +1 more source

Synthesen von Heterocyclen, CCVII Mesoionische Pyrimidine und Thiazine / Syntheses of Heterocycles, CCVII Mesoionic Pyrimidines and Thiazines [PDF]

, 1977
Erich Ziegler, W. Steiger, Charilaos Strangas   +2 more
openalex   +1 more source