Results 121 to 130 of about 121,011 (315)

Feasibility and population exposure of 5‐fluorouracil using therapeutic drug monitoring (PREDICT‐5FU): A multicentre clinical trial

British Journal of Clinical Pharmacology, EarlyView.
Aim PREDICT‐5FU aimed to document 5‐fluorouracil (5FU) exposure in a cancer population and to evaluate the feasibility of 5FU and capecitabine therapeutic drug monitoring (TDM) in patients receiving standard doses and schedules. Methods Multicentre, prospective, observational single‐arm study.
Sarah Glewis, Michael Michael, Howard Gurney, Ian Olver, Nicholas Zdenkowski, Stephen Ackland, Craig Kukard, Madawa Jayawardana, S. Sandun M. Silva, Marliese Alexander, Jeanne Tie, Peter Galettis, Jennifer H. Martin   +12 more
wiley   +1 more source

RESEARCHES ON PYRIMIDINES: SYNTHESIS OF URACIL-4-ACETIC ACID. [PDF]

, 1908
Henry L. Wheeler, Leonard M. Liddle
openalex   +1 more source

Study on combination therapy for lung cancer through pemetrexed‐loaded mesoporous polydopamine nanoparticles

Journal of Biomedical Materials Research Part A, Volume 111, Issue 2, Page 158-169, February 2023., 2023
Abstract Lung cancer is one of the most commonly diagnosed cancers, and surgical resection is the optimal choice for the primary lung tumor. But for the secondary lung cancer, chemotherapy and combined radiotherapy still are the main strategies. To realize the combined treatment for non‐small cell lung cancer (NSCLC), in this work, a nanoplatform based
Jian Xu, Wei Xu, Zhiqiang Wang, Yuequan Jiang   +3 more
wiley   +1 more source

PYRIMIDINE NUCLEOSIDES AS PRECURSORS OF PYRIMIDINES IN POLYNUCLEOTIDES [PDF]

Journal of Biological Chemistry, 1950
E. Hammarsten, E. Hammarsten, Peter Reichard, Peter Reichard, E. Saluste, E. Saluste   +5 more
openaire   +1 more source

Synthesis and Metal‐Ion Binding Properties of Duplexes Containing Thymine Analogs with 1,2‐Diamine Groups

ChemBioChem, EarlyView.
The findings of thermal denaturation experiments indicate that duplexes containing thymine analogues with 1,2‐ethylenediamine side chains show stabilizing effects with six metal ions (e.g., Cu(II), Ni(II), Zn(II), Co(II), Cd(II)). The 1,2‐diamine side chain demonstrated to be useful as a new metal‐ion binding site. Thymidine analogue with a 1,2‐diamino
Takahiro Atsugi, Shoji Fujiwara, Jiro Kondo, Akira Ono   +3 more
wiley   +1 more source

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, EarlyView.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

An Indole Dearomatization Strategy for the Synthesis of Pseudo‐Natural Products

ChemBioChem, Accepted Article.
The indole moiety is a privileged fragment that frequently populates existing bioactive compound collections. We describe the development of an indole‐dearomatization sequence and its application for library expansion of a collection of indole‐containing pseudo‐NPs.
Joseph G.F. Hoock, Annina Burhop, Luca C. Greiner, Beate Schölermann, Celine Da Cruz Lopes Guita, Jie Liu, Sukdev Bag, Axel Pahl, Sonja Sievers, Rebecca Scheel, Carsten Strohmann, Slava Ziegler, Michael Grigalunas, Herbert Waldmann   +13 more
wiley   +1 more source

Studies on Pyrimidine Derivatives. VII. Synthesis of Thiazolo [5, 4-d] pyrimidines and Related Compounds. (7)

, 1958
Shoji Inoue
openalex   +2 more sources

Zur Kenntniss der Pyrimidine [PDF]

, 1897
Siegfried Ruhemann, A. S. Hemmy
openalex   +1 more source

Photo‐Promoted Nitrogen‐Centered Radical Mediated Intermolecular Aminative Carbonylation of Tertiary Allyl Alcohols to Access β‐Amino Ketones through (Hetero)Aryl Migration

ChemistryEurope, EarlyView.
A photocatalyzed aminative carbonylation of unactivated alkenes mediated by nitrogen radicals has been developed. Various β‐aminoketones were produced effectively from allyl alcohols containing different aromatic heterocycles. Abstract Carbon monoxide, as a crucial C1 synthon, has been widely used in the difunctionalization of alkenes.
Ming Hou, Yuanrui Wang, Hefei Yang, Jiajun Zhang, Xiao‐Feng Wu   +4 more
wiley   +1 more source