Results 121 to 130 of about 319,341 (367)
Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2
Nature, 2022 D. Schultz +21 more
semanticscholar +1 more source
Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides
Nature Communications, 2017 Understanding prebiotic nucleotide synthesis is a long standing challenge thought to be essential to elucidating the origins of life on Earth. Recently, remarkable progress has been made, but to date all proposed syntheses account separately for the ...
Shaun Stairs +5 more
semanticscholar +1 more source
On the Origin of Substrate Specificity of Enzymes from the Amidohydrolase Superfamily
Angewandte Chemie International Edition, EarlyView.Comprehensive analyses of two enzyme classes from the amidohydrolase superfamily (AHS) revealed that catalysis proceeds either via 1,4 or 1,6 nucleophilic conjugate addition and that this property defines substrate specificity. Moreover, although all substrates and products are entirely achiral, this mechanistic difference results in an inverted ...
Lukas Drexler +3 more
wiley +1 more source
Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2019 In this study, novel pyrazole, imidazole, pyrimidine derivatives bearing imidazo[4,5-b]indol moiety were successfully synthesized and their chemical structures were identified and confirmed by different spectral techniques.
Nadia Ali Ahmed Elkanzi +2 more
doaj +1 more source
Asia-Pacific Journal of Chemical Engineering, EarlyView.ABSTRACT To address the persistent exceedance of hydrogen sulfide (H2S) concentrations and the limited effectiveness of existing treatments in the Sickle Bay oil production area, this study deeply analyzes the mechanism of H2S generation in the Sickle Bay oil production area and proposes targeted prevention and control strategies. The results show that
Bo Lei +7 more
wiley +1 more source
A tale of three kingdoms: Members of the Phylum Nematoda independently acquired the detoxifying enzyme cyanase through horizontal gene transfer from plants and bacteria [PDF]
, 2018 Horizontal gene transfer (HGT) has played an important role in the evolution of nematodes. Among candidate genes, cyanase, which is typically found only in plants, bacteria and fungi, is present in more than 35 members of the Phylum Nematoda, but absent ...
Hoberg, E. P +5 more
core +2 more sources
Empirical LCAO parameters for $\pi$ molecular orbitals in planar organic molecules
, 2008 We present a parametrization within a simplified LCAO model (a type of Hueckel model) for the description of $\pi$ molecular orbitals in organic molecules containing $\pi$-bonds between carbon, nitrogen, or oxygen atoms with $sp^2$ hybridization, which ...
Hawke, Laurence +2 more
core +3 more sources
Arthritis &Rheumatology, EarlyView.Objective Patients with systemic lupus erythematosus (SLE) experience photosensitivity, with exposure to UVB light driving lupus flares and triggering symptoms like joint pain, fatigue, and cutaneous lesions. Although the mechanism(s) linking UVB exposure to systemic effects are unclear, type I interferons (IFNs) are known to play a role.
Gantsetseg Tumurkhuu +17 more
wiley +1 more source
Журнал органічної та фармацевтичної хімії, 2019 Aim. To study profoundly the antimicrobial activity of the derivatives of 6-(1,2,4-oxadizol-3-yl)- and 6-(2-aminothiazol-4-yl)thieno[2,3-d]pyrimidin-4-ones by the double dilution method. Results and discussion. For the derivatives of 6-heterylthieno[2,3-
Sergiy V. Vlasov +3 more
doaj +1 more source
2′-Fluoro-Pyrimidine-Modified RNA Aptamers Specific for Lipopolysaccharide Binding Protein (LBP) [PDF]
, 2018 Jasmin Aldag +2 more
openalex +1 more source