Results 121 to 130 of about 314,968 (285)
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
Ethyl 2-(4-carboxybenzylidene)-7-methyl-3-oxo-5-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate–N,N-dimethylformamide (1/1) [PDF]
, 2012 Noor Afshan Banu, V. Bheema Raju
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Food Frontiers, EarlyView.We investigated microbial community structure of selenium sand melon (SSJ) inNingxia. We found that UV‐C had significant inactivation effect on many microorganisms in SSJ. The SWeibull2 model was the best fit to the fungal inactivation curve by fitting a variety of models.
Meng‐Yao Fan +9 more
wiley +1 more source
Chromatographic studies of nucleic acids. 1. A technique for the identification and estimation of purine and pyrimidine bases, nucleosides and related substances [PDF]
, 1949 Roy Markham, Johan Smith
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Cell‐Penetrating Poly(disulfide)s
Helvetica Chimica Acta, EarlyView.The first 10 years of cell‐penetrating poly(disulfide)s (CPDs) are reviewed comprehensively. CPDs are prepared by ring‐opening polymerization of cyclic disulfides. The many sidechain structures and diverse biological applications realized so far beyond the original arginines identify CPDs as the most popular current delivery system that operates with ...
Michael Cognet +10 more
wiley +1 more source
Synthesis and biological evaluation of dehydroabietic acid-pyrimidine hybrids as antitumor agents
, 2020 Lin Huang +8 more
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Helvetica Chimica Acta, EarlyView.Chemical evolution of alkaloids inspired the synthesis of a monoterpene alkaloid‐inspired pseudo‐natural product compound collection and revealed a novel de novo pyrimidine biosynthesis inhibitor chemotype. ABSTRACT In pseudo‐natural product (PNP) design, natural product fragments are combined in arrangements not found in nature to afford novel ...
Animesh Biswas +9 more
wiley +1 more source
Synthesis of 3,6-diarylpyrazolo[1,5-a]pyrimidines [PDF]
, 2013 Liu Ju +5 more
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DNA methyltransferase inhibitors in hematological malignancies and solid tumors
International Journal of Cancer, EarlyView.Abstract Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5‐position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor ...
Valentin Wenger +3 more
wiley +1 more source