Results 131 to 140 of about 151,536 (281)

Metabolic Dependency on De Novo Pyrimidine Synthesis Is a Targetable Vulnerability in Platinum-Resistant Ovarian Cancer. [PDF]

Cancer Res
Cardenas H, Wang Y, Zhao G, Hao DX, Isac AM, Hernandez V, Kim U, Qiang W, Zhang HF, Matei D.   +9 more
europepmc   +1 more source

Nucleosides and Nucleotides. 110. [2,3]-Sigmatropic Rearrangement of the Allylic Selenides to Allylic Amines in Sugar Moiety of Pyrimidine Nucleosides: Synthesis of 3'-Amino-2',3'-dideoxy-2'-methylidenecytidine

, 1992
Akira Matsuda, Abdalla Alsyed A. Hassan
openalex   +1 more source

Synthesis and cytotoxic activity of new pyrazolo[1,5-a]pyrimidines and determination of pyrimidine regiospecific ring formation with 2D NMR [PDF]

, 2016
Eman K. A. Abdelall, John N. Philoppes
openalex   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

Design, synthesis and evaluation of new pyrazino[1',2':1,5]pyrrolo[2,3-<i>d</i>]pyrimidines as tacrine-like acetylcholinesterase inhibitors. [PDF]

RSC Adv
Muzychka LV, Muzychka OV, Kobzar OL, Vovk AI, Smolii OB.   +4 more
europepmc   +1 more source

Syntheses of Pyrimidine Derivatives. V

, 1954
Akira Takamizawa
openalex   +2 more sources

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Design, Synthesis, and Antibacterial Evaluation of Pyrido[2,3‑<i>d</i>]Pyrimidine and Pyrido[3,2‑<i>e</i>]Pyrimido[1,2‑<i>c</i>]Pyrimidine Derivatives. [PDF]

ACS Omega
El-Essawy FA, Odah MAA.
europepmc   +1 more source

Small-scale screening program for the identification of cytotoxic Oxazolo[5,4-d]pyrimidine derivatives based on Whole Cell Viability Assay

, 2015
Lawaly Maman Manzo, Yijuan Cheng, Ling Yang, Ji‐Ping Liu, Ya Hui Deng, Li Sun, Yu Liu   +6 more
openalex   +1 more source

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source