Results 141 to 150 of about 314,968 (285)

Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications

Medicinal Research Reviews, EarlyView.
ABSTRACT Targeted radioligand therapy has emerged as a promising treatment option for eradicating advanced cancer forms. α‐Emitters are considered particularly promising as they can obliterate (micro)‐metastases. The α‐emitter astatine‐211 (211At) has experienced increased interest due to its favorable decay properties.
Marius Müller, Nadia Bom Pedersen, Vladimir Shalgunov, Andreas Ingemann Jensen, Umberto Maria Battisti, Matthias Manfred Herth   +5 more
wiley   +1 more source

Sex‐Specific Lasting Metabolome Effects of Adverse Gestational Conditions and Prevention by Myo‐Inositol Supplementation During Suckling

Molecular Nutrition &Food Research, EarlyView.
This graphical abstract illustrates the effects of myo‐inositol supplementation during suckling in reducing long‐term metabolic impacts from mild gestational calorie restriction (GCR). Using a metabolomics approach, 164 metabolites were identified, with greater metabolic alterations in males.
Rocío A. Martín‐Chamorro, Jean‐Charles Martin, Pedro Castillo, Mariona Palou, Andreu Palou, Ana María Rodríguez, Catalina Picó   +6 more
wiley   +1 more source

Pyrimidine Salvage: Physiological Functions and Interaction with Chloroplast Biogenesis [PDF]

, 2019
Lisa Ohler, Sandra Niopek-Witz, Samuel Mainguet, Torsten Moehlmann   +3 more
openalex   +1 more source

Novel Ferrocenyl-substituted Organometallics with Pyrimidine Moiety as Potent Antiprotozoal Agents: Synthesis, Characterization and in Silico Evaluation

, 2023
Humaira Parveen, Mohmmad Younus Wani, Fatimah A. Alotaibi, Sayeed Mukhtar, Uzma Faridi   +4 more
openalex   +1 more source

Design, Synthesis, Bioevaluation, and Bioinformatics Study of 5‐Benzylidene Hydantoin Derivatives as Novel Tyrosine Kinase Inhibitors

ChemistryOpen, EarlyView.
A series of 5‐benzylidene hydantoin derivatives is synthesized and evaluated against eight receptor tyrosine kinases (RTKs). Several compounds show selective and moderate inhibition of human epidermal growth factor receptor 2 (HER2). Molecular docking reveals key interactions with the HER2 active site, highlighting the potential of 5‐benzylidene ...
Muhammad Naufal, Elvira Hermawati, Ade Danova, Ika Wiani Hidayat, Jamaludin Al‐Anshori   +4 more
wiley   +1 more source

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

ChemistryOpen, EarlyView.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda, Sami A. Al‐Hussain, Basant Farag, Mohamed El‐Naggar, Magdi E. A. Zaki, Emad S. A. Alhazmi, Adel S. M. Almohammadi, Sobhi M. Gomha   +7 more
wiley   +1 more source

Insights on Regioselective Synthesis of Fused Thiazoles: Density Functional Theory Calculations, Local Reactivity Indices, and Molecular Electrostatic Potential Analysis

ChemistryOpen, EarlyView.
A regioselective synthesis of fused thiazoles was achieved via aza‐Michael cyclization of thiazolidinone derivatives with hydrazines or heteroaryl amines. Density functional theory, local reactivity indices, and molecular electrostatic potential mapping are used to explain selectivity.
Ghaferah H. Al‐Hazmi, Jehan Y. Al‐Humaidi, Sayed M. Riyadh, Mohamed S. M. Ahmed, Magdi E. A. Zaki, Awatif H. Alruwaili, Khaled A. Alanazi, Rajeh H. Almutairi, Sobhi M. Gomha   +8 more
wiley   +1 more source

Response of <i>Escherichia coli</i> chemotaxis pathway to pyrimidine deoxyribonucleosides. [PDF]

Microbiol Spectr
Shah M, Xu W, Sourjik V.
europepmc   +1 more source

O03: Exploiting narrow therapeutic windows: Utility of the urine purines and pyrimidines test for molybdenum cofactor deficiency A patients*

, 2023
Dayebgadoh Gerald, Silvia Tortorelli, Amy White, Dawn Peck, Gisele Pino, April Studinski, Jason Eckerman, Bimal P. Chaudhari, Betsy Schmalz, Lance H. Rodan, Angela Sun, Emily Shelkowitz, Matthew Schultz, Devin Oglesbee, Dimitar Gavrilov, Patricia Hall, Dietrich Matern, Silvia Tortorelli   +17 more
openalex   +1 more source

A Robust Nanocatalyst Incorporating Multi‐Walled Carbon Nanotubes Infused with Magnetic Nanoparticles and Biguanide–Silver Nanoparticles for Multicomponent Synthesis of Benzopyrano‐Pyrimidines

ChemistryOpen, EarlyView.
A highly efficient and environmentally friendly synthetic method has been developed for the preparation of benzopyrano‐pyrimidines using MWCNTs/MNPs‐Biguanide‐Ag NPs as a heterogeneous nanocatalyst in choline chloride–urea (ChCl–Urea) deep eutectic solvent.
Anwer Ali Mueen, Suranjana V. Mayani, Suhas Ballal, Shaker Al‐Hasnaawei, Abhayveer Singh, Kattela Chennakesavulu, Kamal Kant Joshi, Reza Mohammadi   +7 more
wiley   +1 more source