Results 141 to 150 of about 151,536 (281)

Combining drugs that bypass p53 to treat TP53-mutated leukemias. [PDF]

Blood Adv
Biswas S, Zahran ZAM, Gu X, Cardone L, Marti R, Mouannes N, Stich M, Jain A, Fedorov K, Tomlinson B, Goldfinger M, Verma A, Saunthararajah Y.   +12 more
europepmc   +1 more source

Residue of pyrimidine fungicides in fruits and vegetables (2012–2013) [PDF]

, 2014
Magdalena Słowik‐Borowiec, Anna Kurdziel, Aneta Matyaszek, Magdalena Podbielska, J. Rupar, Ewa Szpyrka   +5 more
openalex   +1 more source

Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3-d]pyrimidine RET Inhibitors

, 2021
Casey J. N. Mathison, Yang Yang, John T. Nelson, Zhihong Huang, Jiqing Jiang, D. CHIANELLI, Paul V. Rucker, Jason Roland, Yun Feng Xie, Robert Epple, Badry Bursulaya, Christian Lee, Mu-Yun Gao, Jennifer Shaffer, Sergio Briones, Yelena Sarkisova, Anna Galkin, Lintong Li, Nanxin Li, Chun Li, Su Hua, Shailaja Kasibhatla, Jacqueline Kinyamu-Akunda, Rie Kikkawa, Valentina Molteni, John E. Tellew   +25 more
openalex   +2 more sources

FB23‐2 and Cisplatin Synergize to Inhibit Head and Neck Squamous Cell Carcinoma by Targeting the XPF/ERCC1 Complex

Cancer Science, EarlyView.
FB23‐2 potentiates cisplatin's antitumor efficacy in head and neck squamous cell carcinoma by disrupting XPF/ERCC1 complex assembly and nuclear translocation, thereby suppressing DNA damage repair machinery and amplifying platinum‐induced tumor cell death.
Yaoqi Jiang, Hongshi Cai, Yue Zhu, Jianfeng Liang, Hongyu Li, Fan Song, Ziyi Wang, Jinsong Hou   +7 more
wiley   +1 more source

Disclosing New Insights on Pyrazolo[3,4-<i>d</i>] Pyrimidine Tethered Diverse Amino Acid Candidates as Potential DHFR Inhibitors and Anti-Virulence Agents. [PDF]

J Microbiol Biotechnol
Ibrahim TS, Salem IM, Alhakamy NA, Al-Mahmoudy AMM, Hegazy WAH.   +4 more
europepmc   +1 more source

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, EarlyView.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

Novel pyrimido[1,2-<i>a</i>]imidazole derivatives as potent Pks13-TE inhibitors: structure-based virtual screening and rational design. [PDF]

RSC Med Chem
Li X, Liu Y, Shao W, Jiang D, Huang X, Rao Z, Peng W, Fang Y.   +7 more
europepmc   +1 more source

Synthesis and Initial SAR Studies of 3,6-Disubstituted Pyrazolo[1,5-a]pyrimidines: A New Class of KDR Kinase Inhibitors

, 2002
Mark E. Fraley, William F. Hoffman, Robert S. Rubino, Randall W. Hungate, Andrew J. Tebben, Ruth Z. Rutledge, Rosemary C. McFall, William R. Huckle, Richard Kendall, Kathleen Coll, Kenneth A. Thomas   +10 more
openalex   +1 more source

Exploring the use of dalfampridine (4‐aminopyridine) for treatment of ataxia in cerebellar stroke

PM&R, EarlyView.
Arjun Kotwal, Prashant Yadav, Veyola Rezkalla, Alison Mautner, Gilbert Siu   +4 more
wiley   +1 more source

A short peptide derived from late embryogenesis abundant proteins enhances acid tolerance in Escherichia coli via modulation of two‐component regulatory systems

The FEBS Journal, EarlyView.
Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley   +1 more source