Results 141 to 150 of about 290,598 (376)
Acta Crystallographica Section E: Crystallographic Communications, 2015 In the title compound, C20H16Cl2N2O2S, the pyrimidine ring has a screw-boat conformation. The attached dichlorophenyl ring is twisted at an angle of 89.29 (13)° with respect to the pyrimidine ring mean plane.
T. Sankar +3 more
doaj +1 more source
RESEARCHES ON PYRIMIDINES: SYNTHESIS OF URACIL-4-ACETIC ACID. [PDF]
, 1908 Henry L. Wheeler, Leonard M. Liddle
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Studies on the Physiology of Pyrimidines. The Metabolism of the Pyrimidine Nucleosides
Experimental Biology and Medicine, 1929 The results of previous work by one of us1 indicated that the pyrimidines uracil and thymine, when fed in small amounts to dogs, are to a large extent metabolized. In the case of cytosine it was found that this substance was not utilized. It was partly excreted unchanged, partly deaminized and excreted in the form of uracil.These experiments were ...
O. H. Emerson, L. R. Cerecedo
openaire +2 more sources
Three Dimensional Quantitative Structure-Activity Relationships of Sulfonamides Binding Monoclonal Antibody by Comparative Molecular Field Analysis [PDF]
, 2008 The three-dimensional quantitative structure-activity relationship (3D-QSAR) model of sulfonamide analogs binding a monoclonal antibody (MabSMR) produced against sulfamerazine, was carried out by comparative molecular field analysis (CoMFA).
Congming Wu +8 more
core +1 more source
Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies
Annals of Neurology, EarlyView.Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel +10 more
wiley +1 more source
, 2000 New developments are presented in the framework of the model introduced by the authors in refs. [1,2] and in which nucleotides as well as codons are classified in crystal bases of the quantum group U_q(sl(2)+sl(2)) in the limit q -> 0.
Frappat, L., Sciarrino, A., Sorba, P.
core +2 more sources
Resolving Ultrafast Photoinduced Deactivations in Water-Solvated Pyrimidine Nucleosides.
Journal of Physical Chemistry Letters, 2017 For the first time, ultrafast deactivations of photoexcited water-solvated pyrimidine nucleosides are mapped employing hybrid QM(CASPT2)/MM(AMBER) optimizations that account for explicit solvation, sugar effects, and dynamically correlated potential ...
A. J. Pepino +4 more
semanticscholar +1 more source
OncoTarget, 2017 Gemcitabine, an anti-cancer chemotherapy drug, has additionally shown the antiviral activity against a broad range of viruses and we also have previously reported its synergistic antiviral activity with ribavirin against enteroviruses.
Kyungjin Lee +5 more
semanticscholar +1 more source
UV-induced damage to DNA: effect of cytosine methylation on pyrimidine dimerization
Signal Transduction and Targeted Therapy, 2017 Methylation/demethylation of cytosine plays an important role in epigenetic signaling, the reversibility of epigenetic modifications offering important opportunities for targeted therapies.
Lara Martínez-Fernández +4 more
semanticscholar +1 more source
Epilepsia Open, EarlyView., 2022 Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines.
Laura Bindila +11 more
wiley +1 more source