Results 151 to 160 of about 197,991 (343)
Metabolic changes during cardiac regeneration in the axolotl
Developmental Dynamics, EarlyView.Abstract Background The axolotl is a prominent model organism of heart regeneration due to its ability to anatomically and functionally repair the heart after an injury that mimics human myocardial infarction. In humans, such an injury leads to permanent scarring. Cardiac regeneration has been linked to metabolism and the oxygenation state, but so far,
Anita Dittrich +10 more
wiley +1 more source
Cross‐Coupling Reactions in Aqueous Micellar Media
European Journal of Organic Chemistry, EarlyView.Aqueous micellar media have emerged as sustainable alternatives to organic solvents for small‐molecule synthesis. This Review discusses the evolution of surfactants for synthesis, their application to cross‐coupling reactions, the benefits for reactivity and sustainability, and the remaining challenges in this rapidly growing field.
Alexander Uner, Liam T. Ball
wiley +1 more source
Multicomponent Synthesis of Fluorine‐Containing Bioactive Compounds and Drugs
European Journal of Organic Chemistry, EarlyView.Multicomponent reactions are robust synthetic tools to assamble complex polyheterocycles and other interesting molecular architectures with potential application in medicinal chemistry, including their fluorine‐containing analogues. Fluorine atoms placed strategically into bioactive molecules often enhance essential pharmacokinetic parameters like ...
Ivette Morales‐Salazar +7 more
wiley +1 more source
Transition Metal‐Free Ortho‐Deuteration of Electron‐Deficient N‐Heteroarenes
European Journal of Organic Chemistry, EarlyView.Herin, the metal‐free, selective deuteration of electron‐deficient N‐heteroaromatics is reported using O‐carbamate and carboxamide ortho‐directing groups (DGs), lithium 2,2,6,6‐tetramethylpiperidide as the base, and D2O as a green source of D+. The substrate scope includes 10 small molecule N‐heteroaromatic compounds and two pharmaceutically relevant ...
Žiga Oražem +5 more
wiley +1 more source
Formation of Enzymes Involved in Pyrimidine Synthesis and Amino Acid Metabolism in Escherichia coli
, 1958 Rose Sheinin
openalex +1 more source
Transferability, Reproducibility and Sensitivity of Mutation Quantification by Duplex Sequencing
Environmental and Molecular Mutagenesis, EarlyView.ABSTRACT Duplex Sequencing (DS) is an ultra‐accurate, error‐corrected next generation sequencing (ecNGS) technology for mutation analysis. A working group (WG) within Health and Environmental Sciences Institute's Genetic Toxicology Technical Committee is investigating the suitability of ecNGS for regulatory mutagenicity testing, using DS as a model ...
Shaofei Zhang +23 more
wiley +1 more source
DEGRADATION OF SUBSTITUTED PYRIMIDINE NUCLEOSIDES BY ESCHERICHIA COLI AND BACILLUS SUBTILIS
, 1954 Irving J. Slotnick +2 more
openalex +1 more source
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source