Results 151 to 160 of about 153,260 (279)

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

Synthesis, DNA-binding and antiproliferative activity of N-(Nitrogen heterocyclic) norcantharidin acylamide acid

Open Chemistry, 2009
Zhu Wen-Zhong, Hu Rui-Ding, Lin Qiu-Yue, Wang Xiao-Xia, Zheng Xiao-Liang   +4 more
doaj   +1 more source

Rational synthesis of pyrazolopyrimidines <i>via</i> cyclocondensation of ynones obtained from the Sonogashira reaction. [PDF]

RSC Adv
Bhagat S, Goel N, Kumari P, Kumar P.
europepmc   +1 more source

Substituted 7-Amino-5-thio-thiazolo[4,5-d]pyrimidines as Potent and Selective Antagonists of the Fractalkine Receptor (CX₃CR1)

, 2013
Sofia Karlström, Gunnar Nordvall, Daniel Sohn, Andreas Hettman, Dominika Turek, Kristofer Åhlin, Annika Kers, Martina Claesson, Can Slivo, Yvonne Lo-Alfredsson, Carl Petersson, Galina Bessidskaia, Per H. Svensson, Tobias Rein, Eva Jerning, Åsa Malmberg, Charlotte Ahlgen, Colin Ray, Lauri Vares, В. В. Иванов, Rolf Johansson   +20 more
openalex   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Pyrimidine-based compounds as promising anticancer agents targeting tumor cell senescence. [PDF]

Mol Ther Oncol
Carpintero-Fernández P, Martínez MM, Carneiro-Figueira A, Martínez R, García-Yuste A, Barturen-Gómez M, Pérez-Caaveiro C, Guitián-Caamaño A, Sarandeses LA, Sestelo JP, Mayán MD.   +10 more
europepmc   +1 more source

Exploring the use of dalfampridine (4‐aminopyridine) for treatment of ataxia in cerebellar stroke

PM&R, EarlyView.
Arjun Kotwal, Prashant Yadav, Veyola Rezkalla, Alison Mautner, Gilbert Siu   +4 more
wiley   +1 more source

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

Metabolic Dependency on De Novo Pyrimidine Synthesis Is a Targetable Vulnerability in Platinum-Resistant Ovarian Cancer. [PDF]

Cancer Res
Cardenas H, Wang Y, Zhao G, Hao DX, Isac AM, Hernandez V, Kim U, Qiang W, Zhang HF, Matei D.   +9 more
europepmc   +1 more source

SYNTHESIS OF SOME NEW SUBSTITUTED PYRIMIDINES AND FUSED PYRIMIDINES [PDF]

, 2010
Ahmed A. Khames
openalex   +1 more source